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Ebselen, a multi-target compound : its effects on biological processes and diseases
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- Lu, Qianqian (author)
- China Three Gorges Univ, Peoples Hosp, Cent Lab, Yichang 443002, Hubei, Peoples R China.;China Three Gorges Univ, Inst Infect & Inflammat, Med Coll, Yichang 443002, Peoples R China.
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- Cai, Yi (author)
- China Three Gorges Univ, Peoples Hosp, Cent Lab, Yichang 443002, Hubei, Peoples R China.;China Three Gorges Univ, Inst Infect & Inflammat, Med Coll, Yichang 443002, Peoples R China.
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- Xiang, Chenyan (author)
- China Three Gorges Univ, Peoples Hosp, Cent Lab, Yichang 443002, Hubei, Peoples R China.
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- China Three Gorges Univ, Peoples Hosp, Cent Lab, Yichang 443002, Hubei, Peoples R China;China Three Gorges Univ, Inst Infect & Inflammat, Med Coll, Yichang 443002, Peoples R China. China Three Gorges Univ, Peoples Hosp, Cent Lab, Yichang 443002, Hubei, Peoples R China. (creator_code:org_t)
- 2021-09-20
- 2021
- English.
- In: Expert Reviews in Molecular Medicine. - : Cambridge University Press. - 1462-3994. ; 23
- Research review (peer-reviewed)
Abstract
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- Ebselen is a well-known synthetic compound mimicking glutathione peroxidase (GPx), which catalyses some vital reactions that protect against oxidative damage. Based on a large number of in vivo and in vitro studies, various mechanisms have been proposed to explain its actions on multiple targets. It targets thiol-related compounds, including cysteine, glutathione, and thiol proteins (e.g., thioredoxin and thioredoxin reductase). Owing to this, ebselen is a unique multifunctional agent with important effects on inflammation, apoptosis, oxidative stress, cell differentiation, immune regulation and neurodegenerative disease, with anti-microbial, detoxifying and anti-tumour activity. This review summarises the current understanding of the multiple biological processes and molecules targeted by ebselen, and its pharmacological applications.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinsk bioteknologi -- Medicinsk bioteknologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Medical Biotechnology -- Medical Biotechnology (hsv//eng)
- NATURVETENSKAP -- Kemi -- Organisk kemi (hsv//swe)
- NATURAL SCIENCES -- Chemical Sciences -- Organic Chemistry (hsv//eng)
Keyword
- Antioxidant
- biological process
- ebselen
- multiple targets
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- Wu, Tao
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- Wang, Jun
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- Zou, Lili
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