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The multifaceted PDCD10/CCM3 gene
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- Valentino, Mariaelena (author)
- FIRC Inst Mol Oncol IFOM, I-20139 Milan 16, Italy.
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- Dejana, Elisabetta (author)
- Uppsala universitet,Vaskulärbiologi,FIRC Inst Mol Oncol IFOM, I-20139 Milan 16, Italy.;Univ Milan, Dept Oncol & Haematooncol, I-20122 Milan 7, Italy.
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- Malinverno, Matteo (author)
- FIRC Inst Mol Oncol IFOM, I-20139 Milan 16, Italy.
- FIRC Inst Mol Oncol IFOM, I-20139 Milan 16, Italy Vaskulärbiologi (creator_code:org_t)
- Elsevier, 2021
- 2021
- English.
- In: Genes & Diseases. - : Elsevier. - 2352-4820 .- 2352-3042. ; 8:6, s. 798-813
- Research review (peer-reviewed)
Abstract
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- The programmed cell death 10 (PDCD10) gene was originally identified as an apoptosis-related gene, although it is now usually known as CCM3, as the third causative gene of cerebral cavernous malformation (CCM). CCM is a neurovascular disease that is characterized by vascular malformations and is associated with headaches, seizures, focal neurological deficits, and cerebral hemorrhage. The PDCD10/CCM3 protein has multiple subcellular localizations and interacts with several multi-protein complexes and signaling pathways. Thus PDCD10/CCM3 governs many cellular functions, which include cell-to-cell junctions and cytoskeleton organization, cell proliferation and apoptosis, and exocytosis and angiogenesis. Given its central role in the maintenance of homeostasis of the cell, dysregulation of PDCD10/CCM3 can result in a wide range of altered cell functions. This can lead to severe diseases, including CCM, cognitive disability, and several types of cancers. Here, we review the multifaceted roles of PDCD10/CCM3 in physiology and pathology, with a focus on its functions beyond CCM. Copyright (C) 2021, Chongqing Medical University. Production and hosting by Elsevier B.V.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)
Keyword
- Cancer
- Cell signaling
- Cell-cycle
- Neurovascular unit
- PDCD10/CCM3
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