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Annotation of pitui...
Annotation of pituitary neuroendocrine tumors with genome-wide expression analysis
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- Abdellah, Tebani (author)
- KTH,Science for Life Laboratory, SciLifeLab,Systembiologi,Normandie Univ, Dept Metab Biochem, UNIROUEN, INSERM,U1245,CHU Rouen, F-76000 Rouen, France.
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- Jotanovic, Jelena (author)
- Uppsala universitet,Klinisk och experimentell patologi,Uppsala Univ, Dept Immunol Genet & Pathol, Uppsala, Sweden.;Uppsala Univ Hosp, Dept Clin Pathol, Uppsala, Sweden.
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- Hekmati, Neda (author)
- Uppsala universitet,Neuroonkologi,Uppsala Univ, Dept Immunol Genet & Pathol, Uppsala, Sweden.
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- Sivertsson, Åsa (author)
- KTH,Science for Life Laboratory, SciLifeLab,Proteinvetenskap
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- Gudjonsson, Olafur (author)
- Uppsala universitet,Enblad: Neurokirurgi,Uppsala Univ, Dept Neurosci, Uppsala, Sweden.
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- Edén Engström, Britt (author)
- Uppsala universitet,Endokrinologi och mineralmetabolism,Uppsala Univ, Dept Med Sci Endocrinol & Mineral Metab, Uppsala, Sweden.
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- Wikström, Johan, 1964- (author)
- Uppsala universitet,Radiologi,Uppsala Univ, Dept Surg Sci, Neuroradiol, Uppsala, Sweden.
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- Uhlén, Mathias (author)
- KTH,Science for Life Laboratory, SciLifeLab,Systembiologi
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- Casar Borota, Olivera (author)
- Uppsala universitet,Science for Life Laboratory, SciLifeLab,Klinisk och experimentell patologi,Uppsala Univ, Dept Immunol Genet & Pathol, Uppsala, Sweden.;Uppsala Univ Hosp, Dept Clin Pathol, Uppsala, Sweden.
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- Pontén, Fredrik (author)
- Uppsala universitet,Science for Life Laboratory, SciLifeLab,Experimentell och klinisk onkologi,Klinisk och experimentell patologi,Uppsala Univ, Dept Immunol Genet & Pathol, Uppsala, Sweden.
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(creator_code:org_t)
- 2021-11-10
- 2021
- English.
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In: Acta neuropathologica communications. - : BioMed Central (BMC). - 2051-5960. ; 9:1
- Related links:
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https://doi.org/10.1...
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https://actaneurocom...
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https://urn.kb.se/re...
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Abstract
Subject headings
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- Pituitary neuroendocrine tumors (PitNETs) are common, generally benign tumors with complex clinical characteristics related to hormone hypersecretion and/or growing sellar tumor mass. PitNETs can be classified based on the expression pattern of anterior pituitary hormones and three main transcriptions factors (TF), SF1, PIT1 and TPIT that regulate differentiation of adenohypophysial cells. Here, we have extended this classification based on the global transcriptomics landscape using tumor tissue from a well-defined cohort comprising 51 PitNETs of different clinical and histological types. The molecular profiles were compared with current classification schemes based on immunohistochemistry. Our results identified three main clusters of PitNETs that were aligned with the main pituitary TFs expression patterns. Our analyses enabled further identification of specific genes and expression patterns, including both known and unknown genes, that could distinguish the three different classes of PitNETs. We conclude that the current classification of PitNETs based on the expression of SF1, PIT1 and TPIT reflects three distinct subtypes of PitNETs with different underlying biology and partly independent from the expression of corresponding hormones. The transcriptomic analysis reveals several potentially targetable tumor-driving genes with previously unknown role in pituitary tumorigenesis.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Klinisk laboratoriemedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Clinical Laboratory Medicine (hsv//eng)
Keyword
- Cellular and Molecular Neuroscience
- Clinical Neurology
- Pathology and Forensic Medicine
- Pathology
- Patologi
- Pathology
- Patologi
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Abdellah, Tebani
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Jotanovic, Jelen ...
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Hekmati, Neda
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Sivertsson, Åsa
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Gudjonsson, Olaf ...
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Edén Engström, B ...
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show more...
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Wikström, Johan, ...
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Uhlén, Mathias
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Casar Borota, Ol ...
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Pontén, Fredrik
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cancer and Oncol ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Clinical Laborat ...
- Articles in the publication
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Acta neuropathol ...
- By the university
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Uppsala University
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Royal Institute of Technology