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Clear Cell Proliferations of the Skin : A Histopathologic Review
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- Zaballos, Pedro (author)
- Hosp Sant Pau Santa & Tecla, Dept Dermatol, Tarragona, Spain.
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- Lara-Valencia, Paola (author)
- Uppsala universitet,Klinisk och experimentell patologi
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- van den Bossche, Karolien (author)
- Dermpatopathol Lab, Ghent, Belgium.
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- Hosp Sant Pau Santa & Tecla, Dept Dermatol, Tarragona, Spain Klinisk och experimentell patologi (creator_code:org_t)
- Wolters Kluwer, 2021
- 2021
- English.
- In: American journal of dermatopathology. - : Wolters Kluwer. - 0193-1091 .- 1533-0311. ; 43:9, s. 607-636
- Research review (peer-reviewed)
Abstract
Subject headings
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- Cutaneous clear cell proliferations encompass a heterogenous group of several primary cutaneous neoplasms and metastatic tumors with different histogenesis. Many of these clear cell proliferations may seem strikingly similar under the microscope resulting in challenging diagnosis. In many of these clear cell lesions, the reason for the clear or pale appearance of proliferating cells is unknown, whereas in other ones, this clear cell appearance is due to intracytoplasmic accumulation of glycogen, mucin, or lipid. Artifacts of tissue processing and degenerative phenomenon may also be responsible for the clear cell appearance of proliferating cells. Awareness of the histopathologic findings as well as histochemical and immunohistochemical techniques are crucial to the accurate diagnosis. This review details the histopathologic features of clear cell cutaneous proliferations, classifying them according their type of differentiation and paying special attention to the histopathologic differential diagnosis among them.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)
Keyword
- clear cells
- pale cells
- cutaneous neoplasms
- immunohistochemistry
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