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A Chromosome-Level Assembly of Blunt Snout Bream (Megalobrama amblycephala) Genome Reveals an Expansion of Olfactory Receptor Genes in Freshwater Fish

Liu, Han (author)
Huazhong Agr Univ, Minist Agr & Rural Affairs, Key Lab Freshwater Anim Breeding,Coll Fisheries, Key Lab Agr Anim Genet Breeding & Reprod,Minist E, Wuhan, Peoples R China.;Minist Educ, Hubei Hongshan Lab Engn Res Ctr Green Dev Convent, Wuhan, Peoples R China.
Chen, Chunhai (author)
BGI Shenzhen, BGI Genom, Shenzhen, Peoples R China.
Lv, Maolin (author)
Huazhong Agr Univ, Minist Agr & Rural Affairs, Key Lab Freshwater Anim Breeding,Coll Fisheries, Key Lab Agr Anim Genet Breeding & Reprod,Minist E, Wuhan, Peoples R China.
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Liu, Ning (author)
Huazhong Agr Univ, Minist Agr & Rural Affairs, Key Lab Freshwater Anim Breeding,Coll Fisheries, Key Lab Agr Anim Genet Breeding & Reprod,Minist E, Wuhan, Peoples R China.
Hu, Yafei (author)
BGI Shenzhen, BGI Genom, Shenzhen, Peoples R China.
Zhang, Hailin (author)
BGI Shenzhen, BGI Genom, Shenzhen, Peoples R China.
Enbody, Erik D. (author)
Uppsala universitet,Institutionen för medicinsk biokemi och mikrobiologi,Science for Life Laboratory, SciLifeLab
Gao, Zexia (author)
Huazhong Agr Univ, Minist Agr & Rural Affairs, Key Lab Freshwater Anim Breeding,Coll Fisheries, Key Lab Agr Anim Genet Breeding & Reprod,Minist E, Wuhan, Peoples R China.;Minist Educ, Hubei Hongshan Lab Engn Res Ctr Green Dev Convent, Wuhan, Peoples R China.
Andersson, Leif (author)
Swedish University of Agricultural Sciences,Sveriges lantbruksuniversitet,Uppsala universitet,Institutionen för medicinsk biokemi och mikrobiologi,Science for Life Laboratory, SciLifeLab,Texas A&M Univ, Dept Vet Integrat Biosci, College Stn, TX 77843 USA.;Swedish Univ Agr Sci, Dept Anim Breeding & Genet, Uppsala, Sweden.,Institutionen för husdjursgenetik (HGEN),Department of Animal Breeding and Genetics,Uppsala University,Texas A&M University
Wang, Weimin (author)
Huazhong Agr Univ, Minist Agr & Rural Affairs, Key Lab Freshwater Anim Breeding,Coll Fisheries, Key Lab Agr Anim Genet Breeding & Reprod,Minist E, Wuhan, Peoples R China.
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Huazhong Agr Univ, Minist Agr & Rural Affairs, Key Lab Freshwater Anim Breeding,Coll Fisheries, Key Lab Agr Anim Genet Breeding & Reprod,Minist E, Wuhan, Peoples R China;Minist Educ, Hubei Hongshan Lab Engn Res Ctr Green Dev Convent, Wuhan, Peoples R China. BGI Shenzhen, BGI Genom, Shenzhen, Peoples R China. (creator_code:org_t)
 
2021-05-18
2021
English.
In: Molecular biology and evolution. - : Oxford University Press. - 0737-4038 .- 1537-1719. ; 38:10, s. 4238-4251
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  • Journal article (peer-reviewed)
Abstract Subject headings
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  • The number of olfactory receptor genes (ORs), which are responsible for detecting diverse odor molecules varies extensively among mammals as a result of frequent gene gains and losses that contribute to olfactory specialization. However, how OR expansions/contractions in fish are influenced by habitat and feeding habit and which OR subfamilies are important in each ecological niche is unknown. Here, we report a major OR expansion in a freshwater herbivorous fish, Megalobrama amblycephala, using a highly contiguous, chromosome-level assembly. We evaluate the possible contribution of OR expansion to habitat and feeding specialization by comparing the OR repertoire in 28 phylogenetically and ecologically diverse teleosts. In total, we analyzed > 4,000 ORs including 3,253 intact, 122 truncated, and 913 pseudogenes. The number of intact ORs is highly variable ranging from 20 to 279. We estimate that the most recent common ancestor of Osteichthyes had 62 intact ORs, which declined in most lineages except the freshwater Otophysa clade that has a substantial expansion in subfamily beta and epsilon ORs. Across teleosts, we found a strong association between duplications of beta and epsilon ORs and freshwater habitat. Nearly, all ORs were expressed in the olfactory epithelium (OE) in three tested fish species. Specifically, all the expanded beta and epsilon ORs were highly expressed in OE of M. amblycephala. Together, we provide molecular and functional evidence for how OR repertoires in fish have undergone gain and loss with respect to ecological factors and highlight the role of beta and epsilon OR in freshwater adaptation.

Subject headings

NATURVETENSKAP  -- Biologi -- Evolutionsbiologi (hsv//swe)
NATURAL SCIENCES  -- Biological Sciences -- Evolutionary Biology (hsv//eng)
NATURVETENSKAP  -- Biologi -- Zoologi (hsv//swe)
NATURAL SCIENCES  -- Biological Sciences -- Zoology (hsv//eng)
NATURVETENSKAP  -- Biologi -- Genetik (hsv//swe)
NATURAL SCIENCES  -- Biological Sciences -- Genetics (hsv//eng)

Keyword

Cyprinid fish
comparative genomics
olfactory receptor
evolutionary dynamics
ecological adaptation

Publication and Content Type

ref (subject category)
art (subject category)

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