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  • Ekström, MagnusLund University,Lunds universitet,Lungmedicin, allergologi och palliativ medicin,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Andfåddhet och kronisk andningssvikt,Forskargrupper vid Lunds universitet,Respiratory Medicine, Allergology, and Palliative Medicine,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine,Breathlessness and chronic respiratory failure,Lund University Research Groups (author)

Breathlessness across generations : results from the RHINESSA generation study

  • Article/chapterEnglish2022

Publisher, publication year, extent ...

  • 2022
  • BMJ,2022
  • electronicrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:uu-459589
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-459589URI
  • https://doi.org/10.1136/thoraxjnl-2021-217271DOI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-185628URI
  • https://lup.lub.lu.se/record/18731f9e-61ca-4eb3-a752-d0baa153033fURI
  • https://gup.ub.gu.se/publication/306485URI

Supplementary language notes

  • Language:English
  • Summary in:English

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  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Background: Breathlessness is a major cause of suffering and disability globally. The symptom relates to multiple factors including asthma and lung function, which are influenced by hereditary factors. No study has evaluated potential inheritance of breathlessness itself across generations.Methods: We analysed the association between breathlessness in parents and their offspring in the Respiratory Health in Northern Europe, Spain and Australia generation study. Data on parents and offspring aged ≥18 years across 10 study centres in seven countries included demographics, self-reported breathlessness, asthma, depression, smoking, physical activity level, measured Body Mass Index and spirometry. Data were analysed using multivariable logistic regression accounting for clustering within centres and between siblings.Results: A total of 1720 parents (mean age at assessment 36 years, 55% mothers) and 2476 offspring (mean 30 years, 55% daughters) were included. Breathlessness was reported by 809 (32.7%) parents and 363 (14.7%) offspring. Factors independently associated with breathlessness in parents and offspring included obesity, current smoking, asthma, depression, lower lung function and female sex. After adjusting for potential confounders, parents with breathlessness were more likely to have offspring with breathlessness, adjusted OR 1.8 (95% CI 1.1 to 2.9). The association was not modified by sex of the parent or offspring.Conclusion: Parents with breathlessness were more likely to have children who developed breathlessness, after adjusting for asthma, lung function, obesity, smoking, depression and female sex in both generations. The hereditary components of breathlessness need to be further explored.

Subject headings and genre

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  • Johannessen, AneDepartment of Global Public Health and Primary Care, University of Bergen, Bergen, Norway (author)
  • Abramson, Michael JSchool of Public Health and Preventive Medicine, Monash University, Victoria, VIC, Melbourne, Australia (author)
  • Benediktsdottir, BryndisDepartment of Sleep, Landspitali University Hospital, Reykjavik, Iceland; Faculty of Medicine, University of Iceland, Reykjavik, Iceland,National University Hospital of Iceland (author)
  • Franklin, KarlUmeå University,Umeå universitet,Kirurgi(Swepub:umu)kafr0021 (author)
  • Gislason, ThorarinnDepartment of Sleep, Landspitali University Hospital, Reykjavik, Iceland; Faculty of Medicine, University of Iceland, Reykjavik, Iceland,National University Hospital of Iceland (author)
  • Gómez Real, FranciscoDepartment of Clinical Science, University of Bergen, Bergen, Norway; Department of Obstetrics and Gynecology, Haukeland University Hospital, Bergen, Norway (author)
  • Holm, Mathias,1969Gothenburg University,Göteborgs universitet,University of Gothenburg,Institutionen för medicin, avdelningen för samhällsmedicin och folkhälsa,Institute of Medicine, School of Public Health and Community Medicine(Swepub:gu)xhomat (author)
  • Janson, ChristerUppsala University,Uppsala universitet,Arbets- och miljömedicin,Lung- allergi- och sömnforskning,Department of Medical Sciences, Uppsala University, Uppsala, Sweden(Swepub:uu)chrisjn (author)
  • Jögi, RainUppsala universitet,Lung- allergi- och sömnforskning,The Lung Clinic, Tartu University Hospital, Tartu, Estonia(Swepub:uu)raijo735 (author)
  • Lowe, AdrianMelbourne School of Population and Global Health, University of Melbourne, Victoria, VIC, Melbourne, Australia (author)
  • Malinovschi, Andrei,1978-Uppsala University,Uppsala universitet,Integrativ Fysiologi,Klinisk fysiologi,Lung- allergi- och sömnforskning,Department of Medical Sciences, Uppsala University, Uppsala, Sweden(Swepub:lu)an6820ma (author)
  • Martínez-Moratalla, JesúsServicio de Pneumologla Del Complejo Hospitalario Universitario de Albacete (CHUA), Servicio de Salud de Castilla-La Mancha (SESCAM), Albacete, Spain,University of Castilla La Mancha (author)
  • Oudin, AnnaUmeå University,Umeå universitet,Avdelningen för hållbar hälsa(Swepub:umu)anou0004 (author)
  • Sánchez-Ramos, José LuisNursing Department, University of Huelva, Huelva, Spain (author)
  • Schlünssen, ViviDepartment of Public Health Environment, Work and Health, Danish Ramazzini Center, Aarhus University, Aarhus, Denmark; Department of Public Health, Department of Public Health, Environment, Work and Health, Danish Ramazzini Center, Copenhagen, Denmark (author)
  • Svanes, CecilieDepartment of Global Public Health and Primary Care, University of Bergen, Bergen, Norway; Department of Occupational Medicine, Haukeland University Hospital, Bergen, Norway (author)
  • Lungmedicin, allergologi och palliativ medicinSektion II (creator_code:org_t)

Related titles

  • In:Thorax: BMJ77:2, s. 172-1770040-63761468-3296

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