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The Tonsil Lymphocy...
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Carrasco, AnnaKarolinska Inst, Karolinska Univ Hosp, Dept Med Huddinge, Ctr Infect Med, Stockholm, Sweden.,Center for Infectious Medicine, Department of Medicine Huddinge, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden
(author)
The Tonsil Lymphocyte Landscape in Pediatric Tonsil Hyperplasia and Obstructive Sleep Apnea
- Article/chapterEnglish2021
Publisher, publication year, extent ...
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2021-10-22
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Frontiers Media S.A.2021
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electronicrdacarrier
Numbers
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LIBRIS-ID:oai:DiVA.org:uu-459784
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-459784URI
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https://doi.org/10.3389/fimmu.2021.674080DOI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:148046498URI
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https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-189619URI
Supplementary language notes
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Language:English
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Summary in:English
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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De två första författarna delar förstaförfattarskapet.De två sista författarna delar sistaförfattarskapet.
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Tonsil hyperplasia is the most common cause of pediatric obstructive sleep apnea (OSA). Despite the growing knowledge in tissue immunology of tonsils, the immunopathology driving tonsil hyperplasia and OSA remains unknown. Here we used multi-parametric flow cytometry to analyze the composition and phenotype of tonsillar innate lymphoid cells (ILCs), T cells, and B cells from pediatric patients with OSA, who had previous polysomnography. Unbiased clustering analysis was used to delineate and compare lymphocyte heterogeneity between two patient groups: children with small tonsils and moderate OSA (n = 6) or large tonsils and very severe OSA (n = 13). We detected disturbed ILC and B cell proportions in patients with large tonsils, characterized by an increase in the frequency of naive CD27(-)CD21(hi) B cells and a relative reduction of ILCs. The enrichment of naive B cells was not commensurate with elevated Ki67 expression, suggesting defective differentiation and/or migration rather than cellular proliferation to be the causative mechanism. Finally, yet importantly, we provide the flow cytometry data to be used as a resource for additional translational studies aimed at investigating the immunological mechanisms of pediatric tonsil hyperplasia and OSA.
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Added entries (persons, corporate bodies, meetings, titles ...)
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Sjölander, IsabellaUppsala universitet,Öron-, näs- och halssjukdomar,Department of Surgical Sciences, Otorhinolaryngology-Head and Neck Surgery, Uppsala University, Uppsala, Sweden(Swepub:uu)isasj364
(author)
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Van Acker, AlineKarolinska Inst, Karolinska Univ Hosp, Dept Med Huddinge, Ctr Infect Med, Stockholm, Sweden.,Center for Infectious Medicine, Department of Medicine Huddinge, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden
(author)
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Dernstedt, AndyUmeå universitet,Institutionen för klinisk mikrobiologi(Swepub:umu)ande0033
(author)
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Fehrm, JohanKarolinska Institutet,Department of Clinical Sciences, Intervention, and Technology, Karolinska Institutet, Stockholm, Sweden
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Forsell, Mattias N. E.Umeå universitet,Institutionen för klinisk mikrobiologi(Swepub:umu)mafo0173
(author)
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Friberg, DanielleUppsala universitet,Öron-, näs- och halssjukdomar,Department of Surgical Sciences, Otorhinolaryngology-Head and Neck Surgery, Uppsala University, Uppsala, Sweden(Swepub:uu)danfr874
(author)
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Mjösberg, JennyKarolinska Inst, Karolinska Univ Hosp, Dept Med Huddinge, Ctr Infect Med, Stockholm, Sweden.,Center for Infectious Medicine, Department of Medicine Huddinge, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden
(author)
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Rao, AnnaKarolinska Inst, Karolinska Univ Hosp, Dept Med Huddinge, Ctr Infect Med, Stockholm, Sweden.,Center for Infectious Medicine, Department of Medicine Huddinge, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden
(author)
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Karolinska Inst, Karolinska Univ Hosp, Dept Med Huddinge, Ctr Infect Med, Stockholm, Sweden.Center for Infectious Medicine, Department of Medicine Huddinge, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden
(creator_code:org_t)
Related titles
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In:Frontiers in Immunology: Frontiers Media S.A.121664-3224
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