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A combined genome-w...
A combined genome-wide association and molecular study of age-related hearing loss in H. sapiens
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- Liu, Wei (author)
- Uppsala universitet,Öron-, näs- och halssjukdomar
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- Johansson, Åsa (author)
- Uppsala universitet,Science for Life Laboratory, SciLifeLab,Medicinsk genetik och genomik
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- Rask-Andersen, Helge (author)
- Uppsala universitet,Öron-, näs- och halssjukdomar
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- Rask-Andersen, Mathias, 1979- (author)
- Uppsala universitet,Medicinsk genetik och genomik,Science for Life Laboratory, SciLifeLab
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(creator_code:org_t)
- 2021-12-01
- 2021
- English.
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In: BMC Medicine. - : BioMed Central (BMC). - 1741-7015. ; 19:1
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Abstract
Subject headings
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- BACKGROUND: Sensorineural hearing loss is one of the most common sensory deficiencies. However, the molecular contribution to age-related hearing loss is not fully elucidated.METHODS: We performed genome-wide association studies (GWAS) for hearing loss-related traits in the UK Biobank (N = 362,396) and selected a high confidence set of ten hearing-associated gene products for staining in human cochlear samples: EYA4, LMX1A, PTK2/FAK, UBE3B, MMP2, SYNJ2, GRM5, TRIOBP, LMO-7, and NOX4.RESULTS: All proteins were found to be expressed in human cochlear structures. Our findings illustrate cochlear structures that mediate mechano-electric transduction of auditory stimuli, neuronal conductance, and neuronal plasticity to be involved in age-related hearing loss.CONCLUSIONS: Our results suggest common genetic variation to influence structural resilience to damage as well as cochlear recovery after trauma, which protect against accumulated damage to cochlear structures and the development of hearing loss over time.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Medicinsk genetik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Medical Genetics (hsv//eng)
Keyword
- Age-related hearing loss
- GWAS
- Human gene expression
- Structured illumination microscopy
Publication and Content Type
- ref (subject category)
- art (subject category)
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