SwePub
Sök i LIBRIS databas

  Extended search

onr:"swepub:oai:DiVA.org:uu-460518"
 

Search: onr:"swepub:oai:DiVA.org:uu-460518" > Large scale discove...

  • 1 of 1
  • Previous record
  • Next record
  •    To hitlist

Large scale discovery of coronavirus-host factor protein interaction motifs reveals SARS-CoV-2 specific mechanisms and vulnerabilities

Kruse, Thomas (author)
The Novo Nordisk Foundation Center for Protein Research, University of Copenhagen, Faculty of Health and Medical Sciences, Blegdamsvej 3B, Copenhagen, Denmark
Benz, Caroline (author)
Uppsala universitet,Biokemi,Department of Chemistry - BMC, Uppsala University, Box 576, Husargatan 3, Uppsala, Sweden
Garvanska, Dimitriya H. (author)
The Novo Nordisk Foundation Center for Protein Research, University of Copenhagen, Faculty of Health and Medical Sciences, Blegdamsvej 3B, Copenhagen, Denmark
show more...
Lindquist, Richard, 1985- (author)
Umeå universitet,Institutionen för klinisk mikrobiologi,Molekylär Infektionsmedicin, Sverige (MIMS)
Mihalic, Filip (author)
Uppsala universitet,Institutionen för medicinsk biokemi och mikrobiologi,Department of Medical Biochemistry and Microbiology, Uppsala University, BMC, Box 582, Husargatan 3, Uppsala, Sweden
Coscia, Fabian (author)
The Novo Nordisk Foundation Center for Protein Research, University of Copenhagen, Faculty of Health and Medical Sciences, Blegdamsvej 3B, Copenhagen, Denmark; Spatial Proteomics Group, Max Delbrück Center for Molecular Medicine in the Helmholtz Association, Berlin, Germany
Inturi, Raviteja, 1985- (author)
Uppsala universitet,Institutionen för medicinsk biokemi och mikrobiologi,Department of Medical Biochemistry and Microbiology, Uppsala University, BMC, Box 582, Husargatan 3, Uppsala, Sweden
Sayadi, Ahmed (author)
Uppsala universitet,Biokemi,Department of Chemistry - BMC, Uppsala University, Box 576, Husargatan 3, Uppsala, Sweden
Simonetti, Leandro (author)
Uppsala universitet,Biokemi,Department of Chemistry - BMC, Uppsala University, Box 576, Husargatan 3, Uppsala, Sweden
Nilsson, Emma (author)
Umeå universitet,Institutionen för klinisk mikrobiologi,Molekylär Infektionsmedicin, Sverige (MIMS)
Ali, Muhammad, 1990- (author)
Karolinska Institutet,Uppsala universitet,Biokemi,Department of Chemistry - BMC, Uppsala University, Box 576, Husargatan 3, Uppsala, Sweden
Kliche, Johanna (author)
Uppsala universitet,Biokemi,Department of Chemistry - BMC, Uppsala University, Box 576, Husargatan 3, Uppsala, Sweden
Moliner Morro, Ainhoa (author)
Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden
Mund, Andreas (author)
The Novo Nordisk Foundation Center for Protein Research, University of Copenhagen, Faculty of Health and Medical Sciences, Blegdamsvej 3B, Copenhagen, Denmark
Andersson, Eva (author)
Uppsala universitet,Institutionen för medicinsk biokemi och mikrobiologi,Department of Medical Biochemistry and Microbiology, Uppsala University, BMC, Box 582, Husargatan 3, Uppsala, Sweden
McInerney, Gerald (author)
Karolinska Institutet,Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden
Mann, Matthias (author)
The Novo Nordisk Foundation Center for Protein Research, University of Copenhagen, Faculty of Health and Medical Sciences, Blegdamsvej 3B, Copenhagen, Denmark
Jemth, Per (author)
Uppsala universitet,Institutionen för medicinsk biokemi och mikrobiologi,Department of Medical Biochemistry and Microbiology, Uppsala University, BMC, Box 582, Husargatan 3, Uppsala, Sweden
Davey, Norman E. (author)
Division of Cancer Biology, The Institute of Cancer Research, 237 Fulham Road, London, United Kingdom
Överby, Anna K. (author)
Umeå universitet,Institutionen för klinisk mikrobiologi,Molekylär Infektionsmedicin, Sverige (MIMS)
Nilsson, Jakob (author)
The Novo Nordisk Foundation Center for Protein Research, University of Copenhagen, Faculty of Health and Medical Sciences, Blegdamsvej 3B, Copenhagen, Denmark
Ivarsson, Ylva (author)
Uppsala universitet,Biokemi,Department of Chemistry - BMC, Uppsala University, Box 576, Husargatan 3, Uppsala, Sweden
show less...
 (creator_code:org_t)
2021-11-19
2021
English.
In: Nature Communications. - : Springer Nature. - 2041-1723. ; 12:1
Related links:
https://doi.org/10.1...
show more...
https://uu.diva-port... (primary) (Raw object)
https://www.nature.c...
https://umu.diva-por... (primary) (Raw object)
https://urn.kb.se/re...
https://doi.org/10.1...
http://kipublication...
https://urn.kb.se/re...
show less...
  • Journal article (peer-reviewed)
Abstract Subject headings
Close  
  • Viral proteins make extensive use of short peptide interaction motifs to hijack cellular host factors. However, most current large-scale methods do not identify this important class of protein-protein interactions. Uncovering peptide mediated interactions provides both a molecular understanding of viral interactions with their host and the foundation for developing novel antiviral reagents. Here we describe a viral peptide discovery approach covering 23 coronavirus strains that provides high resolution information on direct virus-host interactions. We identify 269 peptide-based interactions for 18 coronaviruses including a specific interaction between the human G3BP1/2 proteins and an ΦxFG peptide motif in the SARS-CoV-2 nucleocapsid (N) protein. This interaction supports viral replication and through its ΦxFG motif N rewires the G3BP1/2 interactome to disrupt stress granules. A peptide-based inhibitor disrupting the G3BP1/2-N interaction dampened SARS-CoV-2 infection showing that our results can be directly translated into novel specific antiviral reagents.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Infektionsmedicin (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Infectious Medicine (hsv//eng)
NATURVETENSKAP  -- Biologi -- Biokemi och molekylärbiologi (hsv//swe)
NATURAL SCIENCES  -- Biological Sciences -- Biochemistry and Molecular Biology (hsv//eng)

Keyword

General Physics and Astronomy
General Biochemistry
Genetics and Molecular Biology
General Chemistry

Publication and Content Type

ref (subject category)
art (subject category)

Find in a library

To the university's database

  • 1 of 1
  • Previous record
  • Next record
  •    To hitlist

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Close

Copy and save the link in order to return to this view