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Fruit, vegetable an...
Fruit, vegetable and dietary antioxidant intake in school age, respiratory health up to young adulthood.
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- Sdona, Emmanouela (author)
- Karolinska Institutet
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- Ekström, Sandra (author)
- Karolinska Institutet
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- Andersson, Niklas (author)
- Karolinska Institutet
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- Hallberg, Jenny (author)
- Karolinska Institutet
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- Rautiainen, Susanne (author)
- Karolinska Institutet
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- Håkansson, Niclas (author)
- Karolinska Institutet
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- Wolk, Alicja (author)
- Karolinska Institutet,Uppsala universitet,Medicinsk epidemiologi,Ortopedi,Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
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- Kull, Inger (author)
- Karolinska Institutet
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- Melén, Erik (author)
- Karolinska Institutet
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- Bergström, Anna (author)
- Karolinska Institutet
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(creator_code:org_t)
- 2021-09-28
- 2022
- English.
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In: Clinical and Experimental Allergy. - : John Wiley & Sons. - 0954-7894 .- 1365-2222. ; 52:1, s. 104-114
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Abstract
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- BACKGROUND: Dietary antioxidants may protect the lung against oxidative damage and prevent chronic respiratory disease. We aimed to investigate fruit, vegetable and antioxidant intake (measured as total antioxidant capacity, TAC) at age 8 years in relation to asthma and lung function up to 24 years.METHODS: In this study of 2506 participants from a Swedish birth cohort, diet was assessed using food frequency questionnaires. Information on asthma was collected by questionnaires, and lung function was measured by spirometry at ages 8, 16 and 24 years. Generalized estimating equations and mixed effect models were used to assess overall, age- and sex-specific associations.RESULTS: After adjustment for confounders, a higher fruit intake at age 8 years was associated with a tendency to reduced odds of prevalent asthma (T3 vs. T1, OR 0.78; 95% CI 0.60-1.01, p-trend .083), with reduced odds of incident asthma and increased odds of remittent asthma (≥median, OR 0.76; 95% CI 0.58-0.99 and OR 1.60; 95% CI 1.05-2.42, respectively) up to 24 years. Comparable, but non-significant, odds ratios were observed in analyses of long-term fruit intake (mean intake at ages 8 and 16 years). In contrast, no association was observed with vegetable intake. A higher dietary TAC (T3 vs. T1) at 8 years was associated with reduced odds of prevalent asthma (OR 0.73; 95% CI 0.58-0.93, p-trend .010) and improved lung function development (FEV1 -z +0.11; 95% CI 0.01-0.21, p-trend .036 and FVC-z +0.09; 95% CI -0.01-0.20, p-trend .072) up to 24 years. Associations were more pronounced among males, and regarding asthma, participants sensitized to aeroallergens.CONCLUSIONS: Antioxidant intake in school age may improve asthma and lung function up to young adulthood. Although our results should be interpreted with caution, they emphasize the importance of following current dietary guidelines regarding consumption of antioxidant-rich foods as part of a balanced diet.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Näringslära (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Nutrition and Dietetics (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Lungmedicin och allergi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Respiratory Medicine and Allergy (hsv//eng)
Keyword
- antioxidants
- asthma
- diet
- fruits
- lung function
Publication and Content Type
- ref (subject category)
- art (subject category)
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Sdona, Emmanouel ...
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Ekström, Sandra
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Andersson, Nikla ...
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Hallberg, Jenny
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Rautiainen, Susa ...
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Håkansson, Nicla ...
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show more...
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Wolk, Alicja
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Kull, Inger
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Melén, Erik
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Bergström, Anna
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Health Sciences
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and Nutrition and Di ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Respiratory Medi ...
- Articles in the publication
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Clinical and Exp ...
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Uppsala University
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Karolinska Institutet