Search: onr:"swepub:oai:DiVA.org:uu-461965" >
Tissue Type Differe...
Tissue Type Differences in ABCB1 Expression and Paclitaxel Tissue Pharmacokinetics in Patients With Esophageal Cancer
-
- van Eerden, Ruben A. G. (author)
- Erasmus MC, Dept Med Oncol, Canc Inst, Rotterdam, Netherlands.
-
- van Doorn, Leni (author)
- Erasmus MC, Dept Med Oncol, Canc Inst, Rotterdam, Netherlands.
-
- de Man, Femke M. (author)
- Erasmus MC, Dept Med Oncol, Canc Inst, Rotterdam, Netherlands.
-
show more...
-
- Heersche, Niels (author)
- Erasmus MC, Dept Med Oncol, Canc Inst, Rotterdam, Netherlands.
-
- Doukas, Michail (author)
- Erasmus MC, Dept Pathol, Rotterdam, Netherlands.
-
- van den Bosch, Thierry P. P. (author)
- Erasmus MC, Dept Pathol, Rotterdam, Netherlands.
-
- Oomen-de Hoop, Esther (author)
- Erasmus MC, Dept Med Oncol, Canc Inst, Rotterdam, Netherlands.
-
- de Bruijn, Peter (author)
- Erasmus MC, Dept Med Oncol, Canc Inst, Rotterdam, Netherlands.
-
- Bins, Sander (author)
- Erasmus MC, Dept Med Oncol, Canc Inst, Rotterdam, Netherlands.
-
- Ibrahim, Eman (author)
- Uppsala universitet,Institutionen för farmaci
-
- Nikkessen, Suzan (author)
- Erasmus MC, Dept Gastroenterol & Hepatol, Rotterdam, Netherlands.
-
- Friberg, Lena (author)
- Uppsala universitet,Institutionen för farmaci
-
- Koolen, Stijn L. W. (author)
- Erasmus MC, Dept Med Oncol, Canc Inst, Rotterdam, Netherlands.;Erasmus MC, Dept Pharm, Rotterdam, Netherlands.
-
- Spaander, Manon C. W. (author)
- Erasmus MC, Dept Gastroenterol & Hepatol, Rotterdam, Netherlands.
-
- Mathijssen, Ron H. J. (author)
- Erasmus MC, Dept Med Oncol, Canc Inst, Rotterdam, Netherlands.
-
show less...
-
Erasmus MC, Dept Med Oncol, Canc Inst, Rotterdam, Netherlands Erasmus MC, Dept Pathol, Rotterdam, Netherlands. (creator_code:org_t)
- 2021-11-11
- 2021
- English.
-
In: Frontiers in Pharmacology. - : Frontiers Media S.A.. - 1663-9812. ; 12
- Related links:
-
https://doi.org/10.3...
-
show more...
-
https://uu.diva-port... (primary) (Raw object)
-
https://www.frontier...
-
https://urn.kb.se/re...
-
https://doi.org/10.3...
-
show less...
Abstract
Subject headings
Close
- Background: Data from previous work suggests that there is no correlation between systemic (plasma) paclitaxel exposure and efficacy in patients treated for esophageal cancer. In this trial, we investigated ATP-binding cassette efflux transporter expression and intratumoral pharmacokinetics of paclitaxel to identify changes which could be a first sign of chemoresistance.Methods: Patients with esophageal cancer treated with paclitaxel and carboplatin (+/- concomitant radiotherapy) were included. During the first and last cycle of weekly paclitaxel, blood samples and biopsies of esophageal mucosa and tumor tissue were taken. Changes in paclitaxel exposure and expression of ABCB1 (P-glycoprotein) over time were studied in both tumor tissue and normal appearing esophageal mucosa.Results: ABCB1 was significantly higher expressed in tumor tissue compared to esophageal tissue, during both the first and last cycle of paclitaxel (cycle 1: p < 0.01; cycle 5/6: p = 0.01). Interestingly, ABCB1 expression was significantly higher in adenocarcinoma than in squamous cell carcinoma (p < 0.01). During the first cycle, a trend towards a higher intratumoral paclitaxel concentration was observed compared to the esophageal mucosa concentration (RD:43%; 95%CI: -3% to 111% p = 0.07). Intratumoral and plasma paclitaxel concentrations were significantly correlated during the first cycle (AUC(0-48 h): r = 0.72; p < 0.01).Conclusion: Higher ABCB1 expression in tumor tissue, and differences between histological tumor types might partly explain why tumors respond differently to systemic treatment. Resistance by altered intratumoral paclitaxel concentrations could not be demonstrated because the majority of the biopsies taken at the last cycle of paclitaxel did contain a low amount of tumor cells or no tumor.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Keyword
- tissue pharmacokinetics
- intratumoral
- paclitaxel
- pharmacokinetics
- esophageal cancer
- ABCB1
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database
- By the author/editor
-
van Eerden, Rube ...
-
van Doorn, Leni
-
de Man, Femke M.
-
Heersche, Niels
-
Doukas, Michail
-
van den Bosch, T ...
-
show more...
-
Oomen-de Hoop, E ...
-
de Bruijn, Peter
-
Bins, Sander
-
Ibrahim, Eman
-
Nikkessen, Suzan
-
Friberg, Lena
-
Koolen, Stijn L. ...
-
Spaander, Manon ...
-
Mathijssen, Ron ...
-
show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Clinical Medicin ...
-
and Cancer and Oncol ...
- Articles in the publication
-
Frontiers in Pha ...
- By the university
-
Uppsala University