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Determinants of Cog...
Determinants of Cognitive Trajectories in Normal Aging : A Longitudinal PET-MRI Study in a Community-based Cohort
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- Herrmann, Francois R. (author)
- Geneva Univ Hosp, Dept Rehabil & Geriatr, Geneva, Switzerland.;Univ Geneva, Geneva, Switzerland.
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- Montandon, Marie-Louise (author)
- Geneva Univ Hosp, Dept Rehabil & Geriatr, Geneva, Switzerland.;Univ Geneva, Geneva, Switzerland.;Univ Geneva, Dept Psychiat, Geneva, Switzerland.
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- Garibotto, Valentina (author)
- Univ Geneva, Geneva, Switzerland.;Geneva Univ Hosp, Diagnost Dept, Div Nucl Med & Mol Imaging, Geneva, Switzerland.
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- Rodriguez, Cristelle (author)
- Univ Geneva, Dept Psychiat, Geneva, Switzerland.;Univ Geneva Hosp, Med Direct, Geneva, Switzerland.
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- Haller, Sven (author)
- Uppsala universitet,Radiologi,CIMC Ctr Imagerie Med Cornavin, Geneva, Switzerland.;Univ Geneva, Fac Med, Dept Neuroradiol, Geneva, Switzerland.
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- Giannakopoulos, Panteleimon (author)
- Univ Geneva, Dept Psychiat, Geneva, Switzerland.;Univ Geneva Hosp, Med Direct, Geneva, Switzerland.
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Geneva Univ Hosp, Dept Rehabil & Geriatr, Geneva, Switzerland;Univ Geneva, Geneva, Switzerland. Geneva Univ Hosp, Dept Rehabil & Geriatr, Geneva, Switzerland.;Univ Geneva, Geneva, Switzerland.;Univ Geneva, Dept Psychiat, Geneva, Switzerland. (creator_code:org_t)
- Bentham Science Publishers, 2021
- 2021
- English.
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In: Current Alzheimer Research. - : Bentham Science Publishers. - 1567-2050 .- 1875-5828. ; 18:6, s. 482-491
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.2...
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Abstract
Subject headings
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- Background: The determinants of the progressive decrement of cognition in normal aging are still a matter of debate. Alzheimer disease (AD)-signature markers and vascular lesions, but also psychological variables such as personality factors, are thought to have an impact on the longitudinal trajectories of neuropsychological performances in healthy elderly individuals.Objective: The current research aimed to identify the main determinants associated with cognitive trajectories in normal aging.Methods: We performed a 4.5-year longitudinal study in 90 older community-dwellers coupling two neuropsychological assessments, medial temporal atrophy (MTA), number of cerebral microbleeds (CMB), and white matter hyperintensities (WMH) at inclusion, visual rating of amyloid and FDG PET at follow-up, and APOE genotyping. Personality factors were assessed at baseline using the NEO-PIR. Univariate and backward stepwise regression models were built to explore the association between the continuous cognitive score (CCS) and both imaging and personality variables.Results: The number of strictly lobar CMB at baseline (4 or more) was related to a significant increase in the risk of cognitive decrement. In multivariable models, amyloid positivity was associated with a 1.73 unit decrease of the CCS at follow-up. MTA, WMH and abnormal FDG PET were not related to the cognitive outcome. Among personality factors, only higher agreeableness was related to better preservation of neuropsychological performances.Conclusion: CMB and amyloid positivity are the only imaging determinants of cognitive trajectories in this highly selected series of healthy controls. Among personality factors, higher agreeableness confers a modest but significant protection against the decline of cognitive performances.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Geriatrik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Geriatrics (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Radiologi och bildbehandling (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Radiology, Nuclear Medicine and Medical Imaging (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
Keyword
- Amyloid
- atrophy
- cognition
- imaging markers
- microbleeds
- personality
Publication and Content Type
- ref (subject category)
- art (subject category)
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