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Symptom Diaries of ...
Symptom Diaries of Patients with Midgut Neuroendocrine Tumors Treated with 177Lu-DOTATATE
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- Strosberg, Jonathan R. (author)
- H Lee Moffitt Canc Ctr & Res Inst, Tampa, FL 33612 USA.
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- Srirajaskanthan, Rajaventhan (author)
- Kings Coll Hosp London, Dept Gastroenterol, Neuroendocrine Tumour Unit, London, England.
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- El-Haddad, Ghassan (author)
- H Lee Moffitt Canc Ctr & Res Inst, Tampa, FL 33612 USA.
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- Wolin, Edward M. (author)
- Tish Canc Inst Mt Sinai, Ctr Carcinoid & Neuroendocrine Tumors, New York, NY USA.
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- Chasen, Beth R. (author)
- Univ Texas MD Anderson Canc Ctr, Dept Nucl Med, Div Diagnost Imaging, Houston, TX 77030 USA.
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- Kulke, Matthew H. (author)
- Boston Univ, Sect Hematol & Med Oncol, Boston, MA 02215 USA.;Boston Med Ctr, Boston, MA 02215 USA.
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- Bushnell, David L. (author)
- Univ Iowa, Dept Radiol, Iowa City, IA 52242 USA.
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- Caplin, Martyn E. (author)
- Royal Free Hosp, Neuroendocrine Tumour Unit, London, England.
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- Baum, Richard P. (author)
- DKD Helios Clin, Curanosticum Wiesbaden Frankfurt, Wiesbaden, Germany.
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- Hendifar, Andrew E. (author)
- Cedars Sinai Med Ctr, Samuel Oschin Comprehens Canc Inst, Los Angeles, CA 90048 USA.
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- Öberg, Kjell, 1946- (author)
- Uppsala universitet,Endokrin tumörbiologi
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- Ruszniewski, Philippe (author)
- Div Gastroenterol & Pancreatol, Hop Beaujon, Clichy, France.
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- Santoro, Paola (author)
- Adv Accelerator Applicat, Millburn, NJ USA.
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- Broberg, Per (author)
- Adv Accelerator Applicat, Geneva, Switzerland.
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- Leeuwenkamp, Oscar R. (author)
- Adv Accelerator Applicat, Geneva, Switzerland.
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- Krenning, Eric P. (author)
- Erasmus MC, Cyclotron Rotterdam BV, Rotterdam, Netherlands.
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H Lee Moffitt Canc Ctr & Res Inst, Tampa, FL 33612 USA Kings Coll Hosp London, Dept Gastroenterol, Neuroendocrine Tumour Unit, London, England. (creator_code:org_t)
- 2021-03-26
- 2021
- English.
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In: Journal of Nuclear Medicine. - : Society of Nuclear Medicine. - 0161-5505 .- 1535-5667 .- 2159-662X. ; 62:12, s. 1712-1718
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Abstract
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- We report the impact of 177Lu-DOTATATE treatment on abdominal pain, diarrhea, and flushing, symptoms that patients with advanced midgut neuroendocrine tumors often find burdensome.Methods: All patients enrolled in the international randomized phase 3 Neuroendocrine Tumors Therapy (NETTER-1) trial (177Lu-DOTATATE plus standard-dose octreotide long-acting repeatable [LAR], n = 117; high-dose octreotide LAR, n = 114) were asked to record the occurrence of predefined symptoms in a daily diary. Change from baseline in symptom scores (mean number of days with a symptom) was analyzed using a mixed model for repeated measures.Results: Patients (intent-to-treat) who received 177Lu-DOTATATE experienced a significantly greater decline from baseline in symptom scores than patients who received high-dose octreotide LAR. For 177Lu-DOTATATE, the mean decline in days with abdominal pain, diarrhea, and flushing was 4.10, 4.55, and 4.52 d per 4 wk, respectively, compared with 0.99, 1.44, and 2.54 d for high-dose octreotide LAR. The mean differences were 3.11 d (95% CI, 1.35–4.88; P = 0.0007) for abdominal pain, 3.11 d (1.18–5.04; P = 0.0017) for diarrhea, and 1.98 d (0.08–3.88; P = 0.0413) for flushing, favoring 177Lu-DOTATATE. A positive repeated-measures correlation was found between diary-recorded symptom scores and questionnaire-recorded pain, diarrhea, and flushing.Conclusion: In addition to efficacy and quality-of-life benefits, symptom diaries from NETTER-1 demonstrated that treatment with 177Lu-DOTATATE was associated with statistically significant reductions in abdominal pain, diarrhea, and flushing, constituting the core symptoms of patients with progressive midgut neuroendocrine tumors, compared with high-dose octreotide LAR, supporting a beneficial effect of 177Lu-DOTATATE on health-related quality of life.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Radiologi och bildbehandling (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Radiology, Nuclear Medicine and Medical Imaging (hsv//eng)
Keyword
- 177Lu
- neuroendocrine
- symptom diary
- NETTER-1
Publication and Content Type
- ref (subject category)
- art (subject category)
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Strosberg, Jonat ...
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Srirajaskanthan, ...
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El-Haddad, Ghass ...
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Wolin, Edward M.
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Chasen, Beth R.
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Kulke, Matthew H ...
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Bushnell, David ...
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Caplin, Martyn E ...
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Baum, Richard P.
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Hendifar, Andrew ...
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Öberg, Kjell, 19 ...
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Ruszniewski, Phi ...
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Santoro, Paola
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Broberg, Per
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Leeuwenkamp, Osc ...
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Krenning, Eric P ...
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