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Age-adapted percent...
Age-adapted percentiles of measured glomerular filtration in healthy individuals : extrapolation to living kidney donors over 65 years.
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Delanaye, Pierre (author)
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Gaillard, François (author)
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van der Weijden, Jessica (author)
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Mjøen, Geir (author)
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Ferhman-Ekholm, Ingela (author)
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Dubourg, Laurence (author)
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Ebert, Natalie (author)
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Schaeffner, Elke (author)
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- Åkerfeldt, Torbjörn (author)
- Uppsala universitet,Klinisk kemi,Biokemisk endokrinologi
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Goffin, Karolien (author)
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Couzi, Lionel (author)
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Garrouste, Cyril (author)
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Rostaing, Lionel (author)
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Courbebaisse, Marie (author)
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Legendre, Christophe (author)
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Hourmant, Maryvonne (author)
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Kamar, Nassim (author)
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Cavalier, Etienne (author)
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Weekers, Laurent (author)
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Bouquegneau, Antoine (author)
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de Borst, Martin H (author)
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Mariat, Christophe (author)
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Pottel, Hans (author)
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van Londen, Marco (author)
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(creator_code:org_t)
- 2021-10-21
- 2022
- English.
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In: Clinical Chemistry and Laboratory Medicine. - : Walter de Gruyter. - 1434-6621 .- 1437-4331. ; 60:3, s. 401-407
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
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- OBJECTIVES: Most data on glomerular filtration rate (GFR) originate from subjects <65 years old, complicating decision-making in elderly living kidney donors. In this retrospective multi-center study, we calculated percentiles of measured GFR (mGFR) in donors <65 years old and extrapolated these to donors ≥65 years old.METHODS: mGFR percentiles were calculated from a development cohort of French/Belgian living kidney donors <65 years (n=1,983), using quantiles modeled as cubic splines (two linear parts joining at 40 years). Percentiles were extrapolated and validated in an internal cohort of donors ≥65 years (n=147, France) and external cohort of donors and healthy subjects ≥65 years (n=329, Germany, Sweden, Norway, France, The Netherlands) by calculating percentages within the extrapolated 5th-95th percentile (P5-P95).RESULTS: Individuals in the development cohort had a higher mGFR (99.9 ± 16.4 vs. 86.4 ± 14 and 82.7 ± 15.5 mL/min/1.73 m2) compared to the individuals in the validation cohorts. In the internal validation cohort, none (0%) had mGFR below the extrapolated P5, 12 (8.2%) above P95 and 135 (91.8%) between P5-P95. In the external validation cohort, five subjects had mGFR below the extrapolated P5 (1.5%), 25 above P95 (7.6%) and 299 (90.9%) between P5-P95.CONCLUSIONS: We demonstrate that extrapolation of mGFR from younger donors is possible and might aid with decision-making in elderly donors.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Urologi och njurmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Urology and Nephrology (hsv//eng)
Keyword
- elderly
- glomerular filtration rate
- living kidney donors
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Delanaye, Pierre
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Gaillard, Franço ...
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van der Weijden, ...
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Mjøen, Geir
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Ferhman-Ekholm, ...
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Dubourg, Laurenc ...
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show more...
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Ebert, Natalie
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Schaeffner, Elke
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Åkerfeldt, Torbj ...
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Goffin, Karolien
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Couzi, Lionel
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Garrouste, Cyril
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Rostaing, Lionel
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Courbebaisse, Ma ...
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Legendre, Christ ...
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Hourmant, Maryvo ...
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Kamar, Nassim
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Cavalier, Etienn ...
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Weekers, Laurent
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Bouquegneau, Ant ...
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de Borst, Martin ...
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Mariat, Christop ...
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Pottel, Hans
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van Londen, Marc ...
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Urology and Neph ...
- Articles in the publication
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Clinical Chemist ...
- By the university
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Uppsala University