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Robust humoral and ...
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Havervall, SebastianKarolinska Institutet
(author)
Robust humoral and cellular immune responses and low risk for reinfection at least 8 months following asymptomatic to mild COVID-19
- Article/chapterEnglish2022
Publisher, publication year, extent ...
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2021-09-27
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John Wiley & Sons,2022
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electronicrdacarrier
Numbers
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LIBRIS-ID:oai:DiVA.org:uu-464162
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-464162URI
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https://doi.org/10.1111/joim.13387DOI
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https://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-302576URI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:147709627URI
Supplementary language notes
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Language:English
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Summary in:English
Part of subdatabase
Classification
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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De tre första författarna delar förstaförfattarskapetDe fem sista författarna delar sistaförfattarskapet
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QC 20220322
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Background: Emerging data support detectable immune responses for months after severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and vaccination, but it is not yet established to what degree and for how long protection against reinfection lasts.Methods: We investigated SARS-CoV-2-specific humoral and cellular immune responses more than 8 months post-asymptomatic, mild and severe infection in a cohort of 1884 healthcare workers (HCW) and 51 hospitalized COVID-19 patients. Possible protection against SARS-CoV-2 reinfection was analyzed by a weekly 3-month polymerase chain reaction (PCR) screening of 252 HCW that had seroconverted 7 months prior to start of screening and 48 HCW that had remained seronegative at multiple time points.Results: All COVID-19 patients and 96% (355/370) of HCW who were anti-spike IgG positive at inclusion remained anti-spike IgG positive at the 8-month follow-up. Circulating SARS-CoV-2-specific memory T cell responses were detected in 88% (45/51) of COVID-19 patients and in 63% (233/370) of seropositive HCW. The cumulative incidence of PCR-confirmed SARS-CoV-2 infection was 1% (3/252) among anti-spike IgG positive HCW (0.13 cases per 100 weeks at risk) compared to 23% (11/48) among anti-spike IgG negative HCW (2.78 cases per 100 weeks at risk), resulting in a protective effect of 95.2% (95% CI 81.9%-99.1%).Conclusions: The vast majority of anti-spike IgG positive individuals remain anti-spike IgG positive for at least 8 months regardless of initial COVID-19 disease severity. The presence of anti-spike IgG antibodies is associated with a substantially reduced risk of reinfection up to 9 months following asymptomatic to mild COVID-19.
Subject headings and genre
Added entries (persons, corporate bodies, meetings, titles ...)
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Ng, HenryUppsala universitet,Integrativ Fysiologi,Department of Clinical Sciences, Karolinska Institutet Danderyd Hospital, Stockholm, Sweden(Swepub:uu)henng887
(author)
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Jernbom Falk, AugustKTH,Affinitets-proteomik,Science for Life Laboratory, SciLifeLab,Department of Protein Science, SciLifeLab, KTH Royal Institute of Technology, Stockholm, Sweden(Swepub:kth)u1db8k5t
(author)
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Greilert-Norin, NinaDepartment of Clinical Sciences, Karolinska Institutet Danderyd Hospital, Stockholm, Sweden
(author)
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Månberg, Anna,1985-KTH,Science for Life Laboratory, SciLifeLab,Affinitets-proteomik,Department of Protein Science, SciLifeLab, KTH Royal Institute of Technology, Stockholm, Sweden(Swepub:kth)u1g5roxd
(author)
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Marking, UlrikaKarolinska Institutet
(author)
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Laurén, IdaUppsala universitet,Institutionen för farmaci
(author)
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Gabrielsson, LenaDepartment of Clinical Sciences, Karolinska Institutet Danderyd Hospital, Stockholm, Sweden
(author)
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Salomonsson, Ann-ChristinDepartment of Clinical Sciences, Karolinska Institutet Danderyd Hospital, Stockholm, Sweden
(author)
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Aguilera, KatherinaDepartment of Clinical Sciences, Karolinska Institutet Danderyd Hospital, Stockholm, Sweden
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Kihlgren, MarthaDepartment of Clinical Sciences, Karolinska Institutet Danderyd Hospital, Stockholm, Sweden
(author)
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Månsson, MajaDepartment of Clinical Sciences, Karolinska Institutet Danderyd Hospital, Stockholm, Sweden
(author)
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Rosell, AxelKarolinska Institutet
(author)
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Hellström, CeciliaKTH,Affinitets-proteomik,Science for Life Laboratory, SciLifeLab,Department of Protein Science, SciLifeLab, KTH Royal Institute of Technology, Stockholm, Sweden(Swepub:kth)u1doy1fn
(author)
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Andersson, EniKTH,Science for Life Laboratory, SciLifeLab,Affinitets-proteomik,Department of Protein Science, SciLifeLab, KTH Royal Institute of Technology, Stockholm, Sweden(Swepub:kth)u11gerbc
(author)
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Olofsson, JennieKTH,Science for Life Laboratory, SciLifeLab,Affinitets-proteomik,Department of Protein Science, SciLifeLab, KTH Royal Institute of Technology, Stockholm, Sweden(Swepub:kth)u1q8hz5k
(author)
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Skoglund, LovisaDepartment of Protein Science, SciLifeLab, KTH Royal Institute of Technology, Stockholm, Sweden
(author)
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Yousef, JamilDepartment of Protein Science, SciLifeLab, KTH Royal Institute of Technology, Stockholm, Sweden
(author)
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Pin, ElisaKTH,Affinitets-proteomik,Science for Life Laboratory, SciLifeLab,Department of Protein Science, SciLifeLab, KTH Royal Institute of Technology, Stockholm, Sweden(Swepub:kth)u1pmjyje
(author)
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Lord, MartinUppsala universitet,Institutionen för farmaci(Swepub:uu)marlo206
(author)
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Åberg, MikaelUppsala universitet,Science for Life Laboratory, SciLifeLab,Klinisk kemi(Swepub:uu)miabe173
(author)
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Hedhammar, My,Professor,1975-KTH,Proteinteknologi,Science for Life Laboratory, SciLifeLab,Department of Protein Science, SciLifeLab, KTH Royal Institute of Technology, Stockholm, Sweden(Swepub:kth)u1o2n86z
(author)
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Tegel, HannaKTH,Proteinvetenskap,Science for Life Laboratory, SciLifeLab,Department of Protein Science, SciLifeLab, KTH Royal Institute of Technology, Stockholm, Sweden(Swepub:kth)u1nou8yx
(author)
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Dönnes, PierreSciCross AB, Skövde, Sweden
(author)
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Phillipson, Mia,1973-Uppsala universitet,Integrativ Fysiologi(Swepub:uu)mjo07958
(author)
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Nilsson, PeterKTH,Science for Life Laboratory, SciLifeLab,Affinitets-proteomik,Department of Protein Science, SciLifeLab, KTH Royal Institute of Technology, Stockholm, Sweden(Swepub:kth)u1ws88sk
(author)
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Klingström, JonasKarolinska Institutet
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Mangsbo, Sara,1981-Uppsala universitet,Institutionen för farmaci(Swepub:uu)saman132
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Hober, Sophia,Professor,1965-KTH,Science for Life Laboratory, SciLifeLab,Proteinteknologi,Department of Protein Science, SciLifeLab, KTH Royal Institute of Technology, Stockholm, Sweden(Swepub:kth)u11qqzc1
(author)
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Thålin, CharlotteKarolinska Institutet
(author)
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Karolinska InstitutetIntegrativ Fysiologi
(creator_code:org_t)
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In:Journal of Internal Medicine: John Wiley & Sons291:1, s. 72-800954-68201365-2796
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Havervall, Sebas ...
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Ng, Henry
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Jernbom Falk, Au ...
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Greilert-Norin, ...
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Månberg, Anna, 1 ...
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Marking, Ulrika
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Laurén, Ida
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Gabrielsson, Len ...
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Salomonsson, Ann ...
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Aguilera, Kather ...
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Kihlgren, Martha
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Månsson, Maja
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Rosell, Axel
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Hellström, Cecil ...
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Andersson, Eni
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Olofsson, Jennie
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Skoglund, Lovisa
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Yousef, Jamil
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Pin, Elisa
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Lord, Martin
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Åberg, Mikael
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Hedhammar, My, P ...
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Tegel, Hanna
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Dönnes, Pierre
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Phillipson, Mia, ...
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Nilsson, Peter
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Klingström, Jona ...
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Mangsbo, Sara, 1 ...
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Hober, Sophia, P ...
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Thålin, Charlott ...
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Uppsala University
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Royal Institute of Technology
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Karolinska Institutet