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  • Havervall, SebastianKarolinska Institutet (author)

Robust humoral and cellular immune responses and low risk for reinfection at least 8 months following asymptomatic to mild COVID-19

  • Article/chapterEnglish2022

Publisher, publication year, extent ...

  • 2021-09-27
  • John Wiley & Sons,2022
  • electronicrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:uu-464162
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-464162URI
  • https://doi.org/10.1111/joim.13387DOI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-302576URI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:147709627URI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

Classification

  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • De tre första författarna delar förstaförfattarskapetDe fem sista författarna delar sistaförfattarskapet
  • QC 20220322
  • Background: Emerging data support detectable immune responses for months after severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and vaccination, but it is not yet established to what degree and for how long protection against reinfection lasts.Methods: We investigated SARS-CoV-2-specific humoral and cellular immune responses more than 8 months post-asymptomatic, mild and severe infection in a cohort of 1884 healthcare workers (HCW) and 51 hospitalized COVID-19 patients. Possible protection against SARS-CoV-2 reinfection was analyzed by a weekly 3-month polymerase chain reaction (PCR) screening of 252 HCW that had seroconverted 7 months prior to start of screening and 48 HCW that had remained seronegative at multiple time points.Results: All COVID-19 patients and 96% (355/370) of HCW who were anti-spike IgG positive at inclusion remained anti-spike IgG positive at the 8-month follow-up. Circulating SARS-CoV-2-specific memory T cell responses were detected in 88% (45/51) of COVID-19 patients and in 63% (233/370) of seropositive HCW. The cumulative incidence of PCR-confirmed SARS-CoV-2 infection was 1% (3/252) among anti-spike IgG positive HCW (0.13 cases per 100 weeks at risk) compared to 23% (11/48) among anti-spike IgG negative HCW (2.78 cases per 100 weeks at risk), resulting in a protective effect of 95.2% (95% CI 81.9%-99.1%).Conclusions: The vast majority of anti-spike IgG positive individuals remain anti-spike IgG positive for at least 8 months regardless of initial COVID-19 disease severity. The presence of anti-spike IgG antibodies is associated with a substantially reduced risk of reinfection up to 9 months following asymptomatic to mild COVID-19.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Ng, HenryUppsala universitet,Integrativ Fysiologi,Department of Clinical Sciences, Karolinska Institutet Danderyd Hospital, Stockholm, Sweden(Swepub:uu)henng887 (author)
  • Jernbom Falk, AugustKTH,Affinitets-proteomik,Science for Life Laboratory, SciLifeLab,Department of Protein Science, SciLifeLab, KTH Royal Institute of Technology, Stockholm, Sweden(Swepub:kth)u1db8k5t (author)
  • Greilert-Norin, NinaDepartment of Clinical Sciences, Karolinska Institutet Danderyd Hospital, Stockholm, Sweden (author)
  • Månberg, Anna,1985-KTH,Science for Life Laboratory, SciLifeLab,Affinitets-proteomik,Department of Protein Science, SciLifeLab, KTH Royal Institute of Technology, Stockholm, Sweden(Swepub:kth)u1g5roxd (author)
  • Marking, UlrikaKarolinska Institutet (author)
  • Laurén, IdaUppsala universitet,Institutionen för farmaci (author)
  • Gabrielsson, LenaDepartment of Clinical Sciences, Karolinska Institutet Danderyd Hospital, Stockholm, Sweden (author)
  • Salomonsson, Ann-ChristinDepartment of Clinical Sciences, Karolinska Institutet Danderyd Hospital, Stockholm, Sweden (author)
  • Aguilera, KatherinaDepartment of Clinical Sciences, Karolinska Institutet Danderyd Hospital, Stockholm, Sweden (author)
  • Kihlgren, MarthaDepartment of Clinical Sciences, Karolinska Institutet Danderyd Hospital, Stockholm, Sweden (author)
  • Månsson, MajaDepartment of Clinical Sciences, Karolinska Institutet Danderyd Hospital, Stockholm, Sweden (author)
  • Rosell, AxelKarolinska Institutet (author)
  • Hellström, CeciliaKTH,Affinitets-proteomik,Science for Life Laboratory, SciLifeLab,Department of Protein Science, SciLifeLab, KTH Royal Institute of Technology, Stockholm, Sweden(Swepub:kth)u1doy1fn (author)
  • Andersson, EniKTH,Science for Life Laboratory, SciLifeLab,Affinitets-proteomik,Department of Protein Science, SciLifeLab, KTH Royal Institute of Technology, Stockholm, Sweden(Swepub:kth)u11gerbc (author)
  • Olofsson, JennieKTH,Science for Life Laboratory, SciLifeLab,Affinitets-proteomik,Department of Protein Science, SciLifeLab, KTH Royal Institute of Technology, Stockholm, Sweden(Swepub:kth)u1q8hz5k (author)
  • Skoglund, LovisaDepartment of Protein Science, SciLifeLab, KTH Royal Institute of Technology, Stockholm, Sweden (author)
  • Yousef, JamilDepartment of Protein Science, SciLifeLab, KTH Royal Institute of Technology, Stockholm, Sweden (author)
  • Pin, ElisaKTH,Affinitets-proteomik,Science for Life Laboratory, SciLifeLab,Department of Protein Science, SciLifeLab, KTH Royal Institute of Technology, Stockholm, Sweden(Swepub:kth)u1pmjyje (author)
  • Lord, MartinUppsala universitet,Institutionen för farmaci(Swepub:uu)marlo206 (author)
  • Åberg, MikaelUppsala universitet,Science for Life Laboratory, SciLifeLab,Klinisk kemi(Swepub:uu)miabe173 (author)
  • Hedhammar, My,Professor,1975-KTH,Proteinteknologi,Science for Life Laboratory, SciLifeLab,Department of Protein Science, SciLifeLab, KTH Royal Institute of Technology, Stockholm, Sweden(Swepub:kth)u1o2n86z (author)
  • Tegel, HannaKTH,Proteinvetenskap,Science for Life Laboratory, SciLifeLab,Department of Protein Science, SciLifeLab, KTH Royal Institute of Technology, Stockholm, Sweden(Swepub:kth)u1nou8yx (author)
  • Dönnes, PierreSciCross AB, Skövde, Sweden (author)
  • Phillipson, Mia,1973-Uppsala universitet,Integrativ Fysiologi(Swepub:uu)mjo07958 (author)
  • Nilsson, PeterKTH,Science for Life Laboratory, SciLifeLab,Affinitets-proteomik,Department of Protein Science, SciLifeLab, KTH Royal Institute of Technology, Stockholm, Sweden(Swepub:kth)u1ws88sk (author)
  • Klingström, JonasKarolinska Institutet (author)
  • Mangsbo, Sara,1981-Uppsala universitet,Institutionen för farmaci(Swepub:uu)saman132 (author)
  • Hober, Sophia,Professor,1965-KTH,Science for Life Laboratory, SciLifeLab,Proteinteknologi,Department of Protein Science, SciLifeLab, KTH Royal Institute of Technology, Stockholm, Sweden(Swepub:kth)u11qqzc1 (author)
  • Thålin, CharlotteKarolinska Institutet (author)
  • Karolinska InstitutetIntegrativ Fysiologi (creator_code:org_t)

Related titles

  • In:Journal of Internal Medicine: John Wiley & Sons291:1, s. 72-800954-68201365-2796

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