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EULAR recommendatio...
EULAR recommendations for the management of Sjögren's syndrome with topical and systemic therapies.
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- Ramos-Casals, Manuel (author)
- Institutd' Investigacions Biomèdiques August Pi iSunyer (IDIBAPS),Hospital Clínic of Barcelona
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- Brito-Zerón, Pilar (author)
- Institutd' Investigacions Biomèdiques August Pi iSunyer (IDIBAPS),Hospital CIMA
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- Bombardieri, Stefano (author)
- University of Pisa
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- Bootsma, Hendrika (author)
- University of Groningen
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- De Vita, Salvatore (author)
- University Hospital 'Santa Maria della Misericordia'
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- Dörner, Thomas (author)
- Charité - University Medicine Berlin
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- Fisher, Benjamin A (author)
- University of Birmingham,University Hospitals Birmingham
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- Gottenberg, Jacques-Eric (author)
- University of Strasbourg,University Hospital Of Strasbourg
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- Hernandez-Molina, Gabriela (author)
- Salvador Zubirán National Institute of Health Sciences and Nutrition
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- Kocher, Agnes (author)
- Bern University Hospital,University of Bern
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- Kostov, Belchin (author)
- Institutd' Investigacions Biomèdiques August Pi iSunyer (IDIBAPS),Polytechnic University of Catalonia
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- Kruize, Aike A (author)
- University Medical Center Utrecht
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- Mandl, Thomas (author)
- Lund University,Lunds universitet,Internmedicin - epidemiologi,Forskargrupper vid Lunds universitet,Internal Medicine - Epidemiology,Lund University Research Groups,Skåne University Hospital
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- Ng, Wan-Fai (author)
- NIHR Newcastle Biomedical Research Centre,University of Newcastle upon Tyne
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- Retamozo, Soledad (author)
- National University of Cordoba, Argentina,Instituto Universitario de Ciencias Biomédicas de Córdoba
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- Seror, Raphaèle (author)
- Assistance Publique des Hôpitaux de Paris,Bicêtre Hospital
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- Shoenfeld, Yehuda (author)
- Saint Petersburg State University,Sheba Medical Center
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- Sisó-Almirall, Antoni (author)
- El Consorci d’Atenció Primària de Salut Barcelona Esquerra,Institutd' Investigacions Biomèdiques August Pi iSunyer (IDIBAPS)
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- Tzioufas, Athanasios G (author)
- National and Kapodistrian University of Athens
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- Vitali, Claudio (author)
- Villa San Giuseppe Santo Stefano Riabilitazione, Como
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- Bowman, Simon (author)
- University Hospitals Birmingham
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- Mariette, Xavier (author)
- University of Paris-Saclay,Bicêtre Hospital,Assistance Publique des Hôpitaux de Paris
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- Nordmark, Gunnel (contributor)
- Uppsala universitet,Reumatologi,Science for Life Laboratory, SciLifeLab
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(creator_code:org_t)
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- 2019-10-31
- 2020
- English.
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In: Annals of the Rheumatic Diseases. - : BMJ. - 0003-4967 .- 1468-2060. ; 79:1, s. 3-18
- Related links:
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https://ard.bmj.com/...
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http://dx.doi.org/10...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://lup.lub.lu.s...
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Abstract
Subject headings
Close
- The therapeutic management of Sjögren syndrome (SjS) has not changed substantially in recent decades: treatment decisions remain challenging in clinical practice, without a specific therapeutic target beyond the relief of symptoms as the most important goal. In view of this scenario, the European League Against Rheumatism (EULAR) promoted and supported an international collaborative study (EULAR SS Task Force) aimed at developing the first EULAR evidence and consensus-based recommendations for the management of patients with SjS with topical and systemic medications. The aim was to develop a rational therapeutic approach to SjS patients useful for healthcare professionals, physicians undergoing specialist training, medical students, the pharmaceutical industry and drug regulatory organisations following the 2014 EULAR standardised operating procedures. The Task Force (TF) included specialists in rheumatology, internal medicine, oral health, ophthalmology, gynaecology, dermatology and epidemiology, statisticians, general practitioners, nurses and patient representatives from 30 countries of the 5 continents. Evidence was collected from studies including primary SjS patients fulfilling the 2002/2016 criteria; when no evidence was available, evidence from studies including associated SjS or patients fulfilling previous sets of criteria was considered and extrapolated. The TF endorsed the presentation of general principles for the management of patients with SjS as three overarching, general consensus-based recommendations and 12 specific recommendations that form a logical sequence, starting with the management of the central triplet of symptoms (dryness, fatigue and pain) followed by the management of systemic disease. The recommendations address the use of topical oral (saliva substitutes) and ocular (artificial tear drops, topical non-steroidal anti-inflammatory drugs, topical corticosteroids, topical CyA, serum tear drops) therapies, oral muscarinic agonists (pilocarpine, cevimeline), hydroxychloroquine, oral glucocorticoids, synthetic immunosuppressive agents (cyclophosphamide, azathioprine, methotrexate, leflunomide and mycophenolate), and biological therapies (rituximab, abatacept and belimumab). For each recommendation, levels of evidence (mostly modest) and TF agreement (mostly very high) are provided. The 2019 EULAR recommendations are based on the evidence collected in the last 16 years in the management of primary 2002 SjS patients and on discussions between a large and broadly international TF. The recommendations synthesise current thinking on SjS treatment in a set of overarching principles and recommendations. We hope that the current recommendations will be broadly applied in clinical practice and/or serve as a template for national societies to develop local recommendations.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Reumatologi och inflammation (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Rheumatology and Autoimmunity (hsv//eng)
Keyword
- autoimmune diseases
- sjøgren's syndrome
- treatment
Publication and Content Type
- ref (subject category)
- art (subject category)
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Ramos-Casals, Ma ...
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Brito-Zerón, Pil ...
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Bombardieri, Ste ...
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Bootsma, Hendrik ...
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De Vita, Salvato ...
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Dörner, Thomas
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show more...
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Fisher, Benjamin ...
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Gottenberg, Jacq ...
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Hernandez-Molina ...
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Kocher, Agnes
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Kostov, Belchin
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Kruize, Aike A
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Mandl, Thomas
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Ng, Wan-Fai
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Retamozo, Soleda ...
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Seror, Raphaèle
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Shoenfeld, Yehud ...
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Sisó-Almirall, A ...
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Tzioufas, Athana ...
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Vitali, Claudio
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Bowman, Simon
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Mariette, Xavier
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Nordmark, Gunnel
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Rheumatology and ...
- Articles in the publication
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Annals of the Rh ...
- By the university
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Uppsala University
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Lund University