Bleeding avoidance strategies in percutaneous coronary intervention

Capodanno, DavideDivision of Cardiology, Azienda Ospedaliero-Universitaria Policlinico “G. Rodolico-San Marco”, University of Catania, Catania, Italy (author)

For many years, bleeding has been perceived as an unavoidable consequence of strategies aimed at reducing thrombotic complications in patients undergoing percutaneous coronary intervention (PCI). However, the paradigm has now shifted towards bleeding being recognized as a prognostically unfavourable event to the same extent as having a new or recurrent ischaemic or thrombotic complication. As such, in parallel with progress in device and drug development for PCI, there is clinical interest in developing strategies that maximize not only the efficacy but also the safety (for example, by minimizing bleeding) of any antithrombotic treatment or procedural aspect before, during or after PCI. In this Review, we discuss contemporary data and aspects of bleeding avoidance strategies in PCI, including risk stratification, timing of revascularization, pretreatment with antiplatelet agents, selection of vascular access, choice of coronary stents and antithrombotic treatment regimens.

Bhatt, Deepak LDepartment of Medicine, Brigham and Women’s Hospital Heart & Vascular Center, Harvard Medical School, Boston, MA, USA (author)
Gibson, C MichaelDepartment of Medicine, Beth Israel Deaconess Medical Center, Boston, MA, USA (author)
James, Stefan,1964-Uppsala universitet,Institutionen för medicinska vetenskaper,Uppsala kliniska forskningscentrum (UCR)(Swepub:uu)stjam367 (author)
Kimura, TakeshiDepartment of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan (author)
Mehran, RoxanaCardiovascular Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA (author)
Rao, Sunil VThe Duke Clinical Research Institute, Durham, NC, USA (author)
Steg, Philippe GabrielDépartement Hospitalo-Universitaire FIRE, AP-HP, Hôpital Bichat, Paris, France (author)
Urban, PhilipHôpital de la Tour, Geneva, Switzerland (author)
Valgimigli, MarcoCardiocentro Ticino Institute and Università della Svizzera italiana (USI), Lugano, Switzerland (author)
Windecker, StephanDepartment of Cardiology, Bern University Hospital, Bern, Switzerland (author)
Angiolillo, Dominick JUniversity of Florida College of Medicine, Jacksonville, FL, USA (author)
Division of Cardiology, Azienda Ospedaliero-Universitaria Policlinico “G. Rodolico-San Marco”, University of Catania, Catania, ItalyDepartment of Medicine, Brigham and Women’s Hospital Heart & Vascular Center, Harvard Medical School, Boston, MA, USA (creator_code:org_t)

By the author/editor: Capodanno, David ...; Bhatt, Deepak L; Gibson, C Michae ...; James, Stefan, 1 ...; Kimura, Takeshi; Mehran, Roxana; show more...; Rao, Sunil V; Steg, Philippe G ...; Urban, Philip; Valgimigli, Marc ...; Windecker, Steph ...; Angiolillo, Domi ...; show less...

About the subject

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Cardiac and Card ...

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