Progress Identifying and Analyzing the Human Proteome : 2021 Metrics from the HUPO Human Proteome Project

• The 2021 Metrics of the HUPO Human Proteome Project (HPP) show that protein expression has now been credibly detected (neXtProt PE1 level) for 18 357 (92.8%) of the 19 778 predicted proteins coded in the human genome, a gain of 483 since 2020 from reports throughout the world reanalyzed by the HPP. Conversely, the number of neXtProt PE2, PE3, and PE4 missing proteins has been reduced by 478 to 1421. This represents remarkable progress on the proteome parts list. The utilization of proteomics in a broad array of biological and clinical studies likewise continues to expand with many important findings and effective integration with other omics platforms. We present highlights from the Immunopeptidomics, Glycoproteomics, Infectious Disease, Cardiovascular, MusculoSkeletal, Liver, and Cancers B/D-HPP teams and from the Knowledge-base, Mass Spectrometry, Antibody Profiling, and Pathology resource pillars, as well as ethical considerations important to the clinical utilization of proteomics and protein biomarkers.

Subject headings

NATURVETENSKAP  -- Biologi -- Biokemi och molekylärbiologi (hsv//swe)

NATURAL SCIENCES  -- Biological Sciences -- Biochemistry and Molecular Biology (hsv//eng)

Keyword

Human Proteome Project (HPP)

neXtProt protein existence (PE) metrics

missing proteins (MP)

non-MS PE1 proteins

uncharacterized protein existence 1 (uPE1)

Chromosome-centric HPP (C-HPP)

Biology and Disease-HPP (B/D-HPP)

PeptideAtlas

Mass Spectrometry Interactive Virtual Environment (MassIVE)

Human Protein Atlas

Publication and Content Type

ref (subject category)

art (subject category)