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Base-catalysed F-18...
Base-catalysed F-18-labelling of trifluoromethyl ketones. Application to the synthesis of F-18-labelled neutrophil elastase inhibitors
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- Meyer, Denise N. (author)
- Stockholms universitet,Institutionen för organisk kemi,Stockholm Univ, Dept Organ Chem, SE-10691 Stockholm, Sweden.
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- Cortés González, Miguel Á., 1992- (author)
- Stockholms universitet,Institutionen för organisk kemi,Stockholm Univ, Dept Organ Chem, SE-10691 Stockholm, Sweden.
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- Jiang, Xingguo (author)
- Stockholms universitet,Institutionen för organisk kemi,Stockholm Univ, Dept Organ Chem, SE-10691 Stockholm, Sweden.
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- Johansson-Holm, Linus (author)
- Stockholms universitet,Institutionen för organisk kemi,Stockholm Univ, Dept Organ Chem, SE-10691 Stockholm, Sweden.
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- Pourghasemi Lati, Monireh (author)
- Stockholms universitet,Institutionen för organisk kemi,Stockholm Univ, Dept Organ Chem, SE-10691 Stockholm, Sweden.
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- Elgland, Mathias (author)
- Uppsala universitet,Institutionen för läkemedelskemi
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- Nordeman, Patrik, Docent (author)
- Uppsala universitet,Institutionen för läkemedelskemi
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- Antoni, Gunnar (author)
- Uppsala universitet,Preparativ läkemedelskemi
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- Szabó, Kálmán J. (author)
- Stockholms universitet,Institutionen för organisk kemi,Stockholm Univ, Dept Organ Chem, SE-10691 Stockholm, Sweden.
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(creator_code:org_t)
- 2021
- 2021
- English.
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In: Chemical Communications. - : Royal Society of Chemistry. - 1359-7345 .- 1364-548X. ; 57:68, s. 8476-8479
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Abstract
Subject headings
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- A new method for the fluorine-18 labelling of trifluoromethyl ketones has been developed. This method is based on the conversion of a-COCF3 functional group to a difluoro enol silyl ether followed by halogenation and fluorine-18 labelling. The utility of this new method was demonstrated by the synthesis of fluorine-18 labelled neutrophil elastase inhibitors, which are potentially useful for detection of inflammatory disorders.
Subject headings
- NATURVETENSKAP -- Kemi -- Organisk kemi (hsv//swe)
- NATURAL SCIENCES -- Chemical Sciences -- Organic Chemistry (hsv//eng)
- NATURVETENSKAP -- Kemi (hsv//swe)
- NATURAL SCIENCES -- Chemical Sciences (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
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