Search: onr:"swepub:oai:DiVA.org:uu-469028" >
Identification of 3...
Identification of 371 genetic variants for age at first sex and birth linked to externalising behaviour
-
- Mills, Melinda C. (author)
- Univ Oxford, Leverhulme Ctr Demog Sci, Oxford, England.;Univ Oxford, Nuffield Coll, Oxford, England.,University of Oxford
-
- Tropf, Felix C. (author)
- Univ Oxford, Leverhulme Ctr Demog Sci, Oxford, England.;Univ Oxford, Nuffield Coll, Oxford, England.;Ecole Natl Stat & Adm Econ ENSAE, Paris, France.;Ctr Res Econ & Stat CREST, Paris, France.,University of Oxford
-
- Brazel, David M. (author)
- Univ Oxford, Leverhulme Ctr Demog Sci, Oxford, England.;Univ Oxford, Nuffield Coll, Oxford, England.,University of Oxford
-
show more...
-
- van Zuydam, Natalie (author)
- Uppsala universitet,Science for Life Laboratory, SciLifeLab,Institutionen för immunologi, genetik och patologi
-
- Vaez, Ahmad (author)
- Univ Groningen, Univ Med Ctr Groningen, Dept Epidemiol, Groningen, Netherlands.;Isfahan Univ Med Sci, Dept Bioinformat, Esfahan, Iran.,University Medical Center Groningen
-
- Pers, Tune H. (author)
- Univ Copenhagen, Novo Nordisk Fdn, Fac Hlth & Med Sci, Ctr Basic Metab Res, Copenhagen, Denmark.;Statens Serum Inst, Dept Epidemiol Res, Copenhagen, Denmark.,Statens Serum Institut
-
- Snieder, Harold (author)
- Univ Groningen, Univ Med Ctr Groningen, Dept Epidemiol, Groningen, Netherlands.,University Medical Center Groningen
-
- Perry, John R. B. (author)
- Univ Cambridge, Inst Metab Sci, MRC Epidemiol Unit, Cambridge, England.,University of Cambridge
-
- Ong, Ken K. (author)
- Univ Cambridge, Inst Metab Sci, MRC Epidemiol Unit, Cambridge, England.,University of Cambridge
-
- den Hoed, Marcel, 1980- (author)
- Uppsala universitet,Science for Life Laboratory, SciLifeLab,Medicinsk genetik och genomik,Uppsala University
-
- Barban, Nicola (author)
- Univ Bologna, Dept Stat Sci, Bologna, Italy.,University of Bologna
-
- Day, Felix R. (author)
- Univ Cambridge, Inst Metab Sci, MRC Epidemiol Unit, Cambridge, England.,University of Cambridge
-
- Johannesson, Magnus (author)
- Stockholm School of Economics,Handelshögskolan i Stockholm
-
show less...
-
Univ Oxford, Leverhulme Ctr Demog Sci, Oxford, England;Univ Oxford, Nuffield Coll, Oxford, England. University of Oxford (creator_code:org_t)
-
- 2021-07-01
- 2021
- English.
-
In: Nature Human Behaviour. - : Springer Nature. - 2397-3374. ; 5:12, s. 1717-1730
- Related links:
-
https://www.ncbi.nlm...
-
show more...
-
https://urn.kb.se/re...
-
https://doi.org/10.1...
-
https://research.hhs...
-
show less...
Abstract
Subject headings
Close
- Age at first sexual intercourse and age at first birth have implications for health and evolutionary fitness. In this genome-wide association study (age at first sexual intercourse, N = 387,338; age at first birth, N = 542,901), we identify 371 single-nucleotide polymorphisms, 11 sex-specific, with a 5-6% polygenic score prediction. Heritability of age at first birth shifted from 9% [CI = 4-14%] for women born in 1940 to 22% [CI = 19-25%] for those born in 1965. Signals are driven by the genetics of reproductive biology and externalising behaviour, with key genes related to follicle stimulating hormone (FSHB), implantation (ESR1), infertility and spermatid differentiation. Our findings suggest that polycystic ovarian syndrome may lead to later age at first birth, linking with infertility. Late age at first birth is associated with parental longevity and reduced incidence of type 2 diabetes and cardiovascular disease. Higher childhood socioeconomic circumstances and those in the highest polygenic score decile (90%+) experience markedly later reproductive onset. Results are relevant for improving teenage and late-life health, understanding longevity and guiding experimentation into mechanisms of infertility. This genome-wide study of age at first sexual intercourse and first birth identifies 371 signals driven by reproductive biology, externalising behaviour and environmental effects, with later onset associated with lower incidence of some diseases.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Reproduktionsmedicin och gynekologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Obstetrics, Gynaecology and Reproductive Medicine (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)
- NATURVETENSKAP -- Biologi -- Genetik (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Genetics (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database
- By the author/editor
-
Mills, Melinda C ...
-
Tropf, Felix C.
-
Brazel, David M.
-
van Zuydam, Nata ...
-
Vaez, Ahmad
-
Pers, Tune H.
-
show more...
-
Snieder, Harold
-
Perry, John R. B ...
-
Ong, Ken K.
-
den Hoed, Marcel ...
-
Barban, Nicola
-
Day, Felix R.
-
Johannesson, Mag ...
-
show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Clinical Medicin ...
-
and Obstetrics Gynae ...
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Health Sciences
-
and Public Health Gl ...
-
- NATURAL SCIENCES
-
NATURAL SCIENCES
-
and Biological Scien ...
-
and Genetics
- Articles in the publication
-
Nature Human Beh ...
- By the university
-
Uppsala University
-
Stockholm School of Economics