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Identification of 3...
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Mills, Melinda C.Univ Oxford, Leverhulme Ctr Demog Sci, Oxford, England.;Univ Oxford, Nuffield Coll, Oxford, England.,University of Oxford
(author)
Identification of 371 genetic variants for age at first sex and birth linked to externalising behaviour
- Article/chapterEnglish2021
Publisher, publication year, extent ...
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2021-07-01
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Springer Nature,2021
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printrdacarrier
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LIBRIS-ID:oai:DiVA.org:uu-469028
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-469028URI
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https://doi.org/10.1038/s41562-021-01135-3DOI
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https://research.hhs.se/esploro/outputs/journalArticle/Identification-of-371-genetic-variants-for/991001525499506056URI
Supplementary language notes
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Language:English
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Summary in:English
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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These authors contributed equally: Melinda C. Mills, Felix C. Tropf, David M. Brazel, Marcel den Hoed, Nicola Barban, Felix R. Day
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Age at first sexual intercourse and age at first birth have implications for health and evolutionary fitness. In this genome-wide association study (age at first sexual intercourse, N = 387,338; age at first birth, N = 542,901), we identify 371 single-nucleotide polymorphisms, 11 sex-specific, with a 5-6% polygenic score prediction. Heritability of age at first birth shifted from 9% [CI = 4-14%] for women born in 1940 to 22% [CI = 19-25%] for those born in 1965. Signals are driven by the genetics of reproductive biology and externalising behaviour, with key genes related to follicle stimulating hormone (FSHB), implantation (ESR1), infertility and spermatid differentiation. Our findings suggest that polycystic ovarian syndrome may lead to later age at first birth, linking with infertility. Late age at first birth is associated with parental longevity and reduced incidence of type 2 diabetes and cardiovascular disease. Higher childhood socioeconomic circumstances and those in the highest polygenic score decile (90%+) experience markedly later reproductive onset. Results are relevant for improving teenage and late-life health, understanding longevity and guiding experimentation into mechanisms of infertility. This genome-wide study of age at first sexual intercourse and first birth identifies 371 signals driven by reproductive biology, externalising behaviour and environmental effects, with later onset associated with lower incidence of some diseases.
Subject headings and genre
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Tropf, Felix C.Univ Oxford, Leverhulme Ctr Demog Sci, Oxford, England.;Univ Oxford, Nuffield Coll, Oxford, England.;Ecole Natl Stat & Adm Econ ENSAE, Paris, France.;Ctr Res Econ & Stat CREST, Paris, France.,University of Oxford
(author)
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Brazel, David M.Univ Oxford, Leverhulme Ctr Demog Sci, Oxford, England.;Univ Oxford, Nuffield Coll, Oxford, England.,University of Oxford
(author)
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van Zuydam, NatalieUppsala universitet,Science for Life Laboratory, SciLifeLab,Institutionen för immunologi, genetik och patologi
(author)
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Vaez, AhmadUniv Groningen, Univ Med Ctr Groningen, Dept Epidemiol, Groningen, Netherlands.;Isfahan Univ Med Sci, Dept Bioinformat, Esfahan, Iran.,University Medical Center Groningen
(author)
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Pers, Tune H.Univ Copenhagen, Novo Nordisk Fdn, Fac Hlth & Med Sci, Ctr Basic Metab Res, Copenhagen, Denmark.;Statens Serum Inst, Dept Epidemiol Res, Copenhagen, Denmark.,Statens Serum Institut
(author)
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Snieder, HaroldUniv Groningen, Univ Med Ctr Groningen, Dept Epidemiol, Groningen, Netherlands.,University Medical Center Groningen
(author)
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Perry, John R. B.Univ Cambridge, Inst Metab Sci, MRC Epidemiol Unit, Cambridge, England.,University of Cambridge
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Ong, Ken K.Univ Cambridge, Inst Metab Sci, MRC Epidemiol Unit, Cambridge, England.,University of Cambridge
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den Hoed, Marcel,1980-Uppsala universitet,Science for Life Laboratory, SciLifeLab,Medicinsk genetik och genomik,Uppsala University(Swepub:uu)marde358
(author)
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Barban, NicolaUniv Bologna, Dept Stat Sci, Bologna, Italy.,University of Bologna
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Day, Felix R.Univ Cambridge, Inst Metab Sci, MRC Epidemiol Unit, Cambridge, England.,University of Cambridge
(author)
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Johannesson, MagnusStockholm School of Economics,Handelshögskolan i Stockholm(Swepub:hhs)198@hhs.se
(author)
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Univ Oxford, Leverhulme Ctr Demog Sci, Oxford, England.;Univ Oxford, Nuffield Coll, Oxford, England.University of Oxford
(creator_code:org_t)
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Human Reproductive Behaviour Consortium
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In:Nature Human Behaviour: Springer Nature5:12, s. 1717-17302397-3374
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