Sökning: onr:"swepub:oai:DiVA.org:uu-469206" >
Follicular fluid an...
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Bjorvang, Richelle D.Karolinska Institutet,Karolinska Inst, Dept Clin Sci Intervent & Technol, Div Obstet & Gynecol, S-14186 Stockholm, Sweden.;Karolinska Univ Hosp Huddinge, S-14186 Stockholm, Sweden.,Karolinska University Hospital
(författare)
Follicular fluid and blood levels of persistent organic pollutants and reproductive outcomes among women undergoing assisted reproductive technologies
- Artikel/kapitelEngelska2022
Förlag, utgivningsår, omfång ...
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Elsevier,2022
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electronicrdacarrier
Nummerbeteckningar
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LIBRIS-ID:oai:DiVA.org:uu-469206
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-469206URI
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https://doi.org/10.1016/j.envres.2021.112626DOI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:148857814URI
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https://urn.kb.se/resolve?urn=urn:nbn:se:du-46063URI
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https://lup.lub.lu.se/record/ac62e84a-59ce-4378-b591-72622ebb8d57URI
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https://res.slu.se/id/publ/116251URI
Kompletterande språkuppgifter
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:ref swepub-contenttype
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Ämneskategori:art swepub-publicationtype
Anmärkningar
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Persistent organic pollutants (POPs) are industrial chemicals resistant to degradation and have been shown to have adverse effects on reproductive health in wildlife and humans. Although regulations have reduced their levels, they are still ubiquitously present and pose a global concern. Here, we studied a cohort of 185 women aged 21-43 years with a median of 2 years of infertility who were seeking assisted reproductive technology (ART) treatment at the Carl von Linne Clinic in Uppsala, Sweden. We analyzed the levels of 9 organochlorine pesticides (OCPs), 10 polychlorinated biphenyls (PCBs), 3 polybrominated diphenyl ethers (PBDEs), and 8 perfluoroalkyl substances (PFASs) in the blood and follicular fluid (FF) samples collected during ovum pick-up. Impact of age on chemical transfer from blood to FF was analyzed. Associations of chemicals, both individually and as a mixture, to 10 ART endpoints were investigated using linear, logistic, and weighted quantile sum regression, adjusted for age, body mass index, parity, fatty fish intake and cause of infertility. Out of the 30 chemicals, 20 were detected in more than half of the blood samples and 15 in FF. Chemical transfer from blood to FF increased with age. Chemical groups in blood crossed the blood-follicle barrier at different rates: OCPs > PCBs > PFASs. Hexachlorobenzene, an OCP, was associated with lower anti-Miillerian hormone, clinical pregnancy, and live birth. PCBs and PFASs were associated with higher antral follicle count and ovarian response as measured by ovarian sensitivity index, but also with lower embryo quality. As a mixture, similar findings were seen for the sum of PCBs and PFASs. Our results suggest that age plays a role in the chemical transfer from blood to FF and that exposure to POPs significantly associates with ART outcomes. We strongly encourage further studies to elucidate the underlying mechanisms of reproductive effects of POPs in humans.
Ämnesord och genrebeteckningar
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Hallberg, IdaSveriges lantbruksuniversitet,Swedish University of Agricultural Sciences,Institutionen för kliniska vetenskaper (KV),Department of Clinical Sciences(Swepub:slu)48827
(författare)
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Pikki, AnneUppsala University,Uppsala universitet,Institutionen för kvinnors och barns hälsa,Carl von Linnekliniken, S-75183 Uppsala, Sweden.(Swepub:uu)annpi279
(författare)
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Berglund, Lars,Docent,1955-Dalarna University College,Högskolan Dalarna,Uppsala universitet,Uppsala kliniska forskningscentrum (UCR),Geriatrik,Institutionen för medicinska vetenskaper,Dalarna Univ, Sch Hlth & Welf, S-79188 Falun, Sweden.,Medicinsk vetenskap,Uppsala University(Swepub:du)labr
(författare)
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Pedrelli, MatteoKarolinska Institute,Karolinska Institutet,Karolinska Inst, Dept Lab Med, Cardio Metab Unit, S-14152 Stockholm, Sweden.;Karolinska Inst, Dept Med, S-14152 Stockholm, Sweden.;Karolinska Univ Hosp, Med Unit Endocrinol, Theme Inflammat & Ageing, S-14186 Stockholm, Sweden.,Karolinska University Hospital
(författare)
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Kiviranta, HannuFinnish Inst Hlth & Welf, Dept Hlth Secur, Kuopio 70701, Finland.,Finnish National Institute for Health and Welfare
(författare)
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Rantakokko, PanuFinnish Inst Hlth & Welf, Dept Hlth Secur, Kuopio 70701, Finland.,Finnish National Institute for Health and Welfare
(författare)
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Ruokojarvi, PaiviFinnish Inst Hlth & Welf, Dept Hlth Secur, Kuopio 70701, Finland.
(författare)
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Lindh, Christian H.Lund University,Lunds universitet,Avdelningen för arbets- och miljömedicin,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Occupational and Environmental Medicine, Lund University,Department of Laboratory Medicine,Faculty of Medicine(Swepub:lu)ymed-cli
(författare)
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Olovsson, Matts,1958-Uppsala University,Uppsala universitet,Reproduktionsbiologi(Swepub:uu)mattolov
(författare)
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Persson, SaraSveriges lantbruksuniversitet,Swedish University of Agricultural Sciences,Institutionen för kliniska vetenskaper (KV),Department of Clinical Sciences(Swepub:slu)48639
(författare)
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Holte, JanUppsala University,Uppsala universitet,Reproduktionsbiologi,Carl von Linnekliniken, S-75183 Uppsala, Sweden.(Swepub:uu)janho845
(författare)
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Sjunnesson, YlvaSveriges lantbruksuniversitet,Swedish University of Agricultural Sciences,Uppsala universitet,Reproduktionsbiologi,Institutionen för kliniska vetenskaper (KV),Department of Clinical Sciences(Swepub:slu)47737
(författare)
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Damdimopoulou, PauliinaKarolinska Institutet,Karolinska Inst, Dept Clin Sci Intervent & Technol, Div Obstet & Gynecol, S-14186 Stockholm, Sweden.;Karolinska Univ Hosp Huddinge, S-14186 Stockholm, Sweden.,Karolinska University Hospital
(författare)
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Karolinska InstitutetKarolinska Inst, Dept Clin Sci Intervent & Technol, Div Obstet & Gynecol, S-14186 Stockholm, Sweden.;Karolinska Univ Hosp Huddinge, S-14186 Stockholm, Sweden.
(creator_code:org_t)
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Sveriges lantbruksuniversitet
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Ingår i:Environmental Research: Elsevier2080013-93511096-0953
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Bjorvang, Richel ...
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Hallberg, Ida
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Pikki, Anne
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Berglund, Lars, ...
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Pedrelli, Matteo
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Kiviranta, Hannu
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Rantakokko, Panu
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Ruokojarvi, Paiv ...
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Lindh, Christian ...
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Olovsson, Matts, ...
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Persson, Sara
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Holte, Jan
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Sjunnesson, Ylva
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Damdimopoulou, P ...
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