Sökning: onr:"swepub:oai:DiVA.org:uu-469881" > Extract and molecul...
Fältnamn | Indikatorer | Metadata |
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000 | 06221naa a2200685 4500 | |
001 | oai:DiVA.org:uu-469881 | |
003 | SwePub | |
008 | 220318s2021 | |||||||||||000 ||eng| | |
009 | oai:prod.swepub.kib.ki.se:146484408 | |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-4698812 URI |
024 | 7 | a https://doi.org/10.1111/all.148052 DOI |
024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1464844082 URI |
040 | a (SwePub)uud (SwePub)ki | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Tedner, Sandra G.u Karolinska Institutet4 aut |
245 | 1 0 | a Extract and molecular-based early infant sensitization and associated factors-A PreventADALL study |
264 | c 2021-05-04 | |
264 | 1 | b John Wiley & Sons,c 2021 |
338 | a print2 rdacarrier | |
520 | a Background More knowledge about sensitization patterns in early infancy, including impact of molecular allergology, is needed to help predict future allergy development more accurately. Objective We aimed to determine the prevalence and patterns of allergic sensitization at 3 months of age, and explore possible associated factors. Methods From the Scandinavian antenatally recruited PreventADALL mother-child cohort, we included 1110 3-month infants with available serum. Sensitization was defined as s-IgE of >= 0.1 kU(A)/L by Phadiatop Infant(R) (ThermoFisher Scientific) including birch, cat, grass, dog, milk, egg, peanut and wheat. Further ImmunoCAP analyses to ovomucoid, casein, Ara h 1-3, omega-5-gliadin were performed in food extract s-IgE-positive children. Maternal sensitization was defined as s-IgE >= 0.35 kU(A)/L to Phadiatop(R) (inhalant allergen mix) and/or Fx5 (food allergen mix) at 18-week pregnancy. Results Overall 79 (7.3%) infants had specific sensitization, many with low s-IgE-levels (IQR 0.16-0.81 kU(A)/L), with 78 being sensitized to food extract allergens; 41 to egg, 27 to milk, 10 to peanut, and 25 to wheat. A total of 62/78 were further analysed, 18 (29%) had s-IgE to ovomucoid, casein, Ara h 1-3 and/or omega-5-gliadin. Eight infants (0.7%) were sensitized to inhalant allergens. Maternal sensitization to food allergens was associated with infant sensitization, odds ratio 3.64 (95% CI 1.53-8.68). Conclusion Already at 3 months of age, 7% were sensitized to food, mostly without detectable s-IgE to food allergen molecules, and <1% to inhalant allergens. Maternal food sensitization was associated with infants' sensitization. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Lungmedicin och allergi0 (SwePub)302192 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Respiratory Medicine and Allergy0 (SwePub)302192 hsv//eng |
653 | a birth cohort | |
653 | a IgE | |
653 | a immunoglobulin E antibodies | |
653 | a molecular allergology | |
653 | a sensitization | |
700 | 1 | a Soderhall, Cillau Karolinska Institutet4 aut |
700 | 1 | a Konradsen, Jon R.u Karolinska Institutet4 aut |
700 | 1 | a Bains, Karen E. S.u Oslo Univ Hosp, Div Paediat & Adolescent Med, Oslo, Norway.;Univ Oslo, Fac Med, Inst Clin Med, Oslo, Norway.4 aut |
700 | 1 | a Borres, Magnus P,d 1956-u Uppsala universitet,Pediatrisk inflammations- och metabolismforskning samt barnhälsa4 aut0 (Swepub:uu)magbo385 |
700 | 1 | a Carlsen, Kai-Hakonu Oslo Univ Hosp, Div Paediat & Adolescent Med, Oslo, Norway.;Univ Oslo, Fac Med, Inst Clin Med, Oslo, Norway.4 aut |
700 | 1 | a Carlsen, Karin C. L.u Oslo Univ Hosp, Div Paediat & Adolescent Med, Oslo, Norway.;Univ Oslo, Fac Med, Inst Clin Med, Oslo, Norway.4 aut |
700 | 1 | a Fardig, Martinu Karolinska Institutet4 aut |
700 | 1 | a Gerdin, Sabina W.u Karolinska Institutet4 aut |
700 | 1 | a Gudmundsdottir, Hrefna K.u Oslo Univ Hosp, Div Paediat & Adolescent Med, Oslo, Norway.;Univ Oslo, Fac Med, Inst Clin Med, Oslo, Norway.4 aut |
700 | 1 | a Haugen, Guttormu Univ Oslo, Fac Med, Inst Clin Med, Oslo, Norway.;Oslo Univ Hosp, Div Obstet & Gynaecol, Oslo, Norway.4 aut |
700 | 1 | a Hedlin, Gunillau Karolinska Institutet4 aut |
700 | 1 | a Jonassen, Christine M.u Ostfold Hosp Trust, Ctr Lab Med, Genet Unit, Kalnes, Norway.;Norwegian Univ Life Sci, Fac Chem Biotechnol & Food Sci, As, Norway.4 aut |
700 | 1 | a Kreyberg, Inau Oslo Univ Hosp, Div Paediat & Adolescent Med, Oslo, Norway.;Univ Oslo, Fac Med, Inst Clin Med, Oslo, Norway.4 aut |
700 | 1 | a Magi, Caroline-Aleksi O.u Karolinska Institutet4 aut |
700 | 1 | a Nordhagen, Live S.u Oslo Univ Hosp, Div Paediat & Adolescent Med, Oslo, Norway.;Univ Oslo, Fac Med, Inst Clin Med, Oslo, Norway.;VID Specialized Univ, Oslo, Norway.4 aut |
700 | 1 | a Rehbinder, Eva M.u Univ Oslo, Fac Med, Inst Clin Med, Oslo, Norway.;Oslo Univ Hosp, Dept Dermatol, Oslo, Norway.4 aut |
700 | 1 | a Rudi, Knutu Norwegian Univ Life Sci, Fac Chem Biotechnol & Food Sci, As, Norway.4 aut |
700 | 1 | a Skjerven, Havard O.u Oslo Univ Hosp, Div Paediat & Adolescent Med, Oslo, Norway.;Univ Oslo, Fac Med, Inst Clin Med, Oslo, Norway.4 aut |
700 | 1 | a Staff, Anne C.u Univ Oslo, Fac Med, Inst Clin Med, Oslo, Norway.;Oslo Univ Hosp, Div Obstet & Gynaecol, Oslo, Norway.4 aut |
700 | 1 | a Vettukattil, Riyasu Oslo Univ Hosp, Div Paediat & Adolescent Med, Oslo, Norway.;Univ Oslo, Fac Med, Inst Clin Med, Oslo, Norway.4 aut |
700 | 1 | a van Hage, Marianneu Karolinska Institutet4 aut |
700 | 1 | a Nordlund, Bjornu Karolinska Institutet4 aut |
700 | 1 | a Asarnoj, Annau Karolinska Institutet4 aut |
710 | 2 | a Karolinska Institutetb Oslo Univ Hosp, Div Paediat & Adolescent Med, Oslo, Norway.;Univ Oslo, Fac Med, Inst Clin Med, Oslo, Norway.4 org |
773 | 0 | t Allergy. European Journal of Allergy and Clinical Immunologyd : John Wiley & Sonsg 76:9, s. 2730-2739q 76:9<2730-2739x 0105-4538x 1398-9995 |
856 | 4 | u https://doi.org/10.1111/all.14805y Fulltext |
856 | 4 | u https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/all.14805 |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-469881 |
856 | 4 8 | u https://doi.org/10.1111/all.14805 |
856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:146484408 |
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