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Quality of Life in ...
Quality of Life in the First Year of Follow-Up in a Randomized Multicenter Trial Assessing the Role of Imaging after Radical Surgery of Stage IIB-C and III Cutaneous Melanoma (TRIM Study)
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- Naeser, Ylva (author)
- Uppsala University,Uppsala universitet,Cancerimmunterapi,Uppsala Univ Hosp, Dept Oncol, Entrance 101,First Level, S-75185 Uppsala, Sweden.,Rudbeck Laboratory, Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden; Department of Oncology, Uppsala University Hospital, Uppsala, Sweden
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- Helgadottir, Hildur (author)
- Karolinska Institute,Karolinska Institutet,Karolinska University Hospital,Karolinska Inst, Sweden; Karolinska Univ Hosp, Sweden
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- Hansson, Johan (author)
- Karolinska Institutet,Karolinska University Hospital,Karolinska Univ Hosp, Sweden
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- Ingvar, Christian (author)
- Lund University,Lunds universitet,Kirurgi, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Lunds Melanomstudiegrupp,Forskargrupper vid Lunds universitet,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Surgery (Lund),Section V,Department of Clinical Sciences, Lund,Faculty of Medicine,Lund Melanoma Study Group,Lund University Research Groups,LUCC: Lund University Cancer Centre,Other Strong Research Environments,Lund Univ, Sweden
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- Elander, Nils (author)
- Linköpings universitet,Linköping University,Avdelningen för kirurgi, ortopedi och onkologi,Medicinska fakulteten,Region Östergötland, Onkologiska kliniken US
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- Flygare, Petra (author)
- Sundsvall Cty Hosp, Dept Oncol, Lasarettsgatan 21, S-85643 Sundsvall, Sweden.,Department of Oncology, Sundsvall County Hospital, Sundsvall, Sweden
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- Nilsson, Cecilia (author)
- Hosp Vastmanland Västerås, Dept Oncol, S-72189 Västerås, Sweden.,Department of Oncology, Hospital of Västmanland Västerås, Västerås, Sweden
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- Jakobsson, Frida (author)
- Örebro Univ Hosp, Dept Oncol, S-70185 Örebro, Sweden.,Department of Oncology, Örebro University Hospital, Örebro, Sweden
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- Valachis, Antonios, 1984- (author)
- Örebro University,Örebro universitet,Institutionen för medicinska vetenskaper,Region Örebro län,Department of Oncology,Örebro Univ, Fac Med & Hlth, Dept Oncol, S-70182 Örebro, Sweden.
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- Papantoniou, Dimitrios (author)
- Ryhov Cty Hosp, Dept Oncol, S-55185 Jönköping, Sweden.,Department of Oncology, Ryhov County Hospital, Jönköping, Sweden
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- Nordin Danfors, Agneta (author)
- Visby Cty Hosp, Dept Oncol, St Goransgatan 5, S-62184 Visby, Sweden. Uppsala Univ, Dept Surg Sci Radiol & Mol Imaging, S-75185 Uppsala, Sweden.,Department of Oncology, Visby County Hospital,Visby, Sweden
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- Johansson, Hemming (author)
- Karolinska Institute,Karolinska University Hospital,Karolinska Inst, Sweden; Karolinska Univ Hosp, Sweden
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- Sundin, Anders, 1954- (author)
- Uppsala University,Uppsala universitet,Radiologi,Department of Surgical Sciences Radiology & Molecular Imaging, Uppsala University, Uppsala, Sweden,Uppsala Univ, Dept Surg Sci Radiol & Mol Imaging, S-75185 Uppsala, Sweden
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- Brandberg, Yvonne (author)
- Karolinska Institute,Karolinska Institutet,Karolinska Inst, Sweden
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- Ullenhag, Gustav (author)
- Uppsala University,Uppsala universitet,Experimentell och klinisk onkologi,Uppsala Univ Hosp, Dept Oncol, Entrance 101,First Level, S-75185 Uppsala, Sweden.,Rudbeck Laboratory, Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden; Department of Oncology, Uppsala University Hospital, Uppsala, Sweden
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(creator_code:org_t)
- 2022-02-18
- 2022
- English.
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In: Cancers. - : MDPI. - 2072-6694. ; 14:4
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https://urn.kb.se/re...
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Abstract
Subject headings
Close
- Simple Summary After surgery of high-risk melanoma, patients are usually followed up by physical examinations. Recommendations regarding imaging vary due to insufficient evidence of the benefit of regular scans. It might also be stressful for patients to undergo imaging. In an ongoing Swedish study, half of the patients are randomized to whole-body imaging in addition to physical examinations. Three imaging procedures are performed during the first year. The main aim of our study was to investigate if imaging during the first year of follow-up affected the patients' well-being. Validated self-reporting questionnaires regarding symptoms of anxiety and depression and quality of life were answered at study start and at 1 year. Questionnaires from 204 recurrence-free patients were analyzed. No differences in either level of anxiety/depression or quality of life were found at 1 year follow-up between the imaging and non-imaging group. These findings can be considered in the formulation of future follow-up programs. The benefit of imaging in the follow-up setting for high-risk melanoma patients is uncertain, and even less is known about the impact of intensive follow-up on the patient ' s quality of life. In 2017, a Swedish prospective randomized multicenter study started, in which high-risk melanoma patients are randomly assigned 1:1 to follow-up by physical examinations +/- whole-body imaging. The first-year examinations are scheduled at 0, 6 and 12 months. The aim of this study was to investigate whether the patients ' health-related quality of life (HRQoL) and levels of anxiety and depression were affected at 1 year by imaging. Anxiety/depression and HRQoL were assessed at 0 and 12 months by the questionnaires Hospital Anxiety and Depression (HAD) scale and EORTC QLQ-C30 version 3. Expected baseline QLQ-C30 values for the patients were calculated using data from the general population. In total, 204 patients were analyzed. Mean differences in subscale scores at 1 year were not statistically significant either for HRQoL or for anxiety/depression. Baseline HRQoL did not differ from expected values in the general Swedish population. In conclusion, the patients in general coped well with the situation, and adding whole-body imaging to physical examinations did not affect the melanoma patients' HRQoL or levels of anxiety or depression.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Radiologi och bildbehandling (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Radiology, Nuclear Medicine and Medical Imaging (hsv//eng)
Keyword
- melanoma
- follow-up studies
- positron emission tomography computed tomography
- tomography
- X-ray computed
- quality of life
- randomized controlled trial
- prospective studies
- Follow-up studies
- Melanoma
- Positron emission tomography computed tomography
- Prospective studies
- Quality of life
- Randomized controlled trial
- Tomography
- X-ray computed
Publication and Content Type
- ref (subject category)
- art (subject category)
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Cancers
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- By the author/editor
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Naeser, Ylva
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Helgadottir, Hil ...
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Hansson, Johan
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Ingvar, Christia ...
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Elander, Nils
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Flygare, Petra
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Nilsson, Cecilia
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Jakobsson, Frida
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Valachis, Antoni ...
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Papantoniou, Dim ...
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Nordin Danfors, ...
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Johansson, Hemmi ...
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Sundin, Anders, ...
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Brandberg, Yvonn ...
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Ullenhag, Gustav
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cancer and Oncol ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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- Articles in the publication
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Cancers
- By the university
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Uppsala University
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Örebro University
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Karolinska Institutet
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Lund University
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Linköping University