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  • Sun, YuShanxi Univ, Inst Environm Sci, Taiyuan, Peoples R China.;South China Agr Univ, Coll Life Sci, Guangdong Prov Key Lab Prot Funct & Regulat Agr O, Guangzhou 510642, Guangdong, Peoples R China.;Guangdong Lab Lingnan Modern Agr, Guangzhou 510642, Guangdong, Peoples R China.;South China Agr Univ, Key Lab Zoonosis, Minist Agr & Rural Affairs, Guangzhou 510642, Guangdong, Peoples R China. (author)

Indoor microbiome, air pollutants and asthma, rhinitis and eczema in preschool children - A repeated cross-sectional study

  • Article/chapterEnglish2022

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  • Elsevier,2022
  • electronicrdacarrier

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  • LIBRIS-ID:oai:DiVA.org:uu-470579
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-470579URI
  • https://doi.org/10.1016/j.envint.2022.107137DOI

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  • Language:English
  • Summary in:English

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  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Background: Indoor microbiome exposure is associated with asthma, rhinitis and eczema. However, no studies report the interactions between environmental characteristics, indoor microbiome and health effects in a repeated cross-sectional framework. Methods: 1,279 and 1,121 preschool children in an industrial city (Taiyuan) of China were assessed for asthma, rhinitis and eczema symptoms in 2012 and 2019 by self-administered questionnaires, respectively. Bacteria and fungi in classroom vacuum dust were characterized by culture-independent amplicon sequencing. Multi-level logistic/linear regression was performed in two cross-sectional and two combined models to assess the associations. Results: The number of observed species in bacterial and fungal communities in classrooms increased significantly from 2012 to 2019, and the compositions of the microbial communities were drastically changed (p < 0.001). The temporal microbiome variation was significantly larger than the spatial variation within the city (p < 0.001). Annual average outdoor SO2 concentration decreased by 60.7%, whereas NO2 and PM10 concentra-tions increased by 63.3% and 40.0% from 2012 to 2019, which were both associated with indoor microbiome variation (PERMANOVA p < 0.001). The prevalence of asthma (2.0% to 3.3%, p = 0.06) and rhinitis (28.0% to 25.3%, p = 0.13) were not significantly changed, but the prevalence of eczema was increased (3.6% to 7.0%; p < 0.001). Aspergillus subversicolor, Collinsella and Cutibacterium were positively associated with asthma, rhinitis and eczema, respectively (p < 0.01). Prevotella, Lactobacillus iners and Dolosigranulum were protectively (negatively) associated with rhinitis (p < 0.01), consistent with previous studies in the human respiratory tract. NO2 and PM10 concentrations were negatively associated with rhinitis in a bivariate model, but a multivariate mediation analysis revealed that Prevotella fully mediated the health effects. Conclusions: This is the first study to report the interactions between environmental characteristics, indoor microbiome and health in a repeated cross-sectional framework. The mediating effects of indoor microorganisms suggest incorporating biological with chemical exposure for a comprehensive exposure assessment.

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  • Meng, YiSouth China Agr Univ, Coll Life Sci, Guangdong Prov Key Lab Prot Funct & Regulat Agr O, Guangzhou 510642, Guangdong, Peoples R China.;Guangdong Lab Lingnan Modern Agr, Guangzhou 510642, Guangdong, Peoples R China.;South China Agr Univ, Key Lab Zoonosis, Minist Agr & Rural Affairs, Guangzhou 510642, Guangdong, Peoples R China. (author)
  • Ou, ZheyuanSouth China Agr Univ, Coll Life Sci, Guangdong Prov Key Lab Prot Funct & Regulat Agr O, Guangzhou 510642, Guangdong, Peoples R China.;Guangdong Lab Lingnan Modern Agr, Guangzhou 510642, Guangdong, Peoples R China.;South China Agr Univ, Key Lab Zoonosis, Minist Agr & Rural Affairs, Guangzhou 510642, Guangdong, Peoples R China. (author)
  • Li, YanlingSouth China Agr Univ, Coll Life Sci, Guangdong Prov Key Lab Prot Funct & Regulat Agr O, Guangzhou 510642, Guangdong, Peoples R China.;Guangdong Lab Lingnan Modern Agr, Guangzhou 510642, Guangdong, Peoples R China.;South China Agr Univ, Key Lab Zoonosis, Minist Agr & Rural Affairs, Guangzhou 510642, Guangdong, Peoples R China. (author)
  • Zhang, MeiSouth China Agr Univ, Coll Life Sci, Guangdong Prov Key Lab Prot Funct & Regulat Agr O, Guangzhou 510642, Guangdong, Peoples R China.;Guangdong Lab Lingnan Modern Agr, Guangzhou 510642, Guangdong, Peoples R China.;South China Agr Univ, Key Lab Zoonosis, Minist Agr & Rural Affairs, Guangzhou 510642, Guangdong, Peoples R China. (author)
  • Chen, YangSouth China Agr Univ, Coll Life Sci, Guangdong Prov Key Lab Prot Funct & Regulat Agr O, Guangzhou 510642, Guangdong, Peoples R China.;Guangdong Lab Lingnan Modern Agr, Guangzhou 510642, Guangdong, Peoples R China.;South China Agr Univ, Key Lab Zoonosis, Minist Agr & Rural Affairs, Guangzhou 510642, Guangdong, Peoples R China. (author)
  • Zhang, ZefeiShanxi Univ, Inst Environm Sci, Taiyuan, Peoples R China. (author)
  • Chen, XingyiShanxi Univ, Inst Environm Sci, Taiyuan, Peoples R China. (author)
  • Mu, PeiqiangSouth China Agr Univ, Coll Life Sci, Guangdong Prov Key Lab Prot Funct & Regulat Agr O, Guangzhou 510642, Guangdong, Peoples R China.;Guangdong Lab Lingnan Modern Agr, Guangzhou 510642, Guangdong, Peoples R China.;South China Agr Univ, Key Lab Zoonosis, Minist Agr & Rural Affairs, Guangzhou 510642, Guangdong, Peoples R China. (author)
  • Norbäck, DanUppsala universitet,Arbets- och miljömedicin(Swepub:uu)dagnorba (author)
  • Zhao, ZhuohuiFudan Univ, Dept Environm Hlth, Sch Publ Hlth,Shanghai Typhoon Inst CMA,Shanghai, Key Lab Publ Hlth Safety,Minist Educ,NHC Key Lab, Shanghai 200030, Peoples R China. (author)
  • Zhang, XinShanxi Univ, Inst Environm Sci, Taiyuan, Peoples R China. (author)
  • Fu, XiGuangdong Pharmaceut Univ, Sch Publ Hlth, Guangzhou 510006, Peoples R China.;Guangdong Pharmaceut Univ, Guangdong Prov Engn Res Ctr Publ Hlth Detect & As, Guangzhou, Peoples R China. (author)
  • Shanxi Univ, Inst Environm Sci, Taiyuan, Peoples R China.;South China Agr Univ, Coll Life Sci, Guangdong Prov Key Lab Prot Funct & Regulat Agr O, Guangzhou 510642, Guangdong, Peoples R China.;Guangdong Lab Lingnan Modern Agr, Guangzhou 510642, Guangdong, Peoples R China.;South China Agr Univ, Key Lab Zoonosis, Minist Agr & Rural Affairs, Guangzhou 510642, Guangdong, Peoples R China.South China Agr Univ, Coll Life Sci, Guangdong Prov Key Lab Prot Funct & Regulat Agr O, Guangzhou 510642, Guangdong, Peoples R China.;Guangdong Lab Lingnan Modern Agr, Guangzhou 510642, Guangdong, Peoples R China.;South China Agr Univ, Key Lab Zoonosis, Minist Agr & Rural Affairs, Guangzhou 510642, Guangdong, Peoples R China. (creator_code:org_t)

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  • In:Environment International: Elsevier1610160-41201873-6750

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