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Missense substitutions lethal to essential functions of EF-Tu
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- Abdulkarim, Farhad (author)
- Uppsala universitet,Institutionen för molekylärbiologi
- Tuohy, TMF (author)
- Buckingham, RH (author)
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- (creator_code:org_t)
- Elsevier BV, 1991
- 1991
- English.
- In: Biochimie. - : Elsevier BV. - 0300-9084 .- 1638-6183. ; 73:12, s. 1457-1464
- Journal article (peer-reviewed)
Abstract
Subject headings
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- We have used a simple selection and screening method to isolate function defective mutants of EF-Tu. From 28 mutants tested, 12 different missense substitutions, individually lethal to some essential function of EF-Tu, were identified by sequencing. In addition we found a new non-lethal missense mutation. The frequency of isolation of unique mutations suggests that this method can be used to easily isolate many more. The lethal mutations occur in all three structural domains of EF-Tu, but most are in domain II. We aim to use these mutants to define functional domains on EF-Tu.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Mikrobiologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Microbiology in the medical area (hsv//eng)
Keyword
- Microbiology, immunology, infectious diseases
- Mikrobiologi, immunologi, infektionssjukdomar
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- art (subject category)
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