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The Role of Nuclear...
The Role of Nuclear Medicine Imaging with F-18-FDG PET/CT, Combined In-111-WBC/(99)mTc-Nanocoll, and Tc-99m-HDP SPECT/CT in the Evaluation of Patients with Chronic Problems after TKA or THA in a Prospective Study
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- Aleksyniene, Ramune (author)
- Aalborg Univ Hosp, Dept Nucl Med, DK-9000 Aalborg, Denmark.
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- Iyer, Victor (author)
- Uppsala universitet,Radiologi,Aalborg Univ Hosp, Dept Nucl Med, DK-9000 Aalborg, Denmark.
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- Bertelsen, Henrik Christian (author)
- Aalborg Univ Hosp, Dept Nucl Med, DK-9000 Aalborg, Denmark.
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- Nilsson, Majbritt Frost (author)
- Aalborg Univ Hosp, Dept Nucl Med, DK-9000 Aalborg, Denmark.
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- Khalid, Vesal (author)
- Aalborg Univ, Dept Clin Med, DK-9220 Aalborg, Denmark.;Aalborg Univ Hosp, Orthopaed Res Unit, DK-9000 Aalborg, Denmark.
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- Schonheyder, Henrik Carl (author)
- Aalborg Univ Hosp, Dept Clin Microbiol, DK-9000 Aalborg, Denmark.
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- Larsen, Lone Heimann (author)
- Aalborg Univ Hosp, Dept Clin Microbiol, DK-9000 Aalborg, Denmark.
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- Nielsen, Poul Torben (author)
- Aalborg Univ Hosp, Dept Orthopaed Surg, Interdisciplinary Orthopaed, DK-9000 Aalborg, Denmark.
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- Kappel, Andreas (author)
- Aalborg Univ Hosp, Dept Orthopaed Surg, Interdisciplinary Orthopaed, DK-9000 Aalborg, Denmark.
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- Thomsen, Trine Rolighed (author)
- Aalborg Univ, Ctr Microbial Communities, DK-9220 Aalborg, Denmark.;Danish Technol Inst, Med Biotechnol, DK-8000 Aarhus, Denmark.
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- Lorenzen, Jan (author)
- Danish Technol Inst, Med Biotechnol, DK-8000 Aarhus, Denmark.
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- Ørsted, Iben (author)
- Aalborg Univ Hosp, Dept Infect Dis, DK-9000 Aalborg, Denmark.
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- Simonsen, Ole (author)
- Aalborg Univ Hosp, Dept Orthopaed Surg, Interdisciplinary Orthopaed, DK-9000 Aalborg, Denmark.
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- Jordal, Peter Lüttge (author)
- Danish Technol Inst, Med Biotechnol, DK-8000 Aarhus, Denmark.
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- Rasmussen, Sten (author)
- Aalborg Univ, Dept Clin Med, DK-9220 Aalborg, Denmark.;Aalborg Univ Hosp, Orthopaed Res Unit, DK-9000 Aalborg, Denmark.
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Aalborg Univ Hosp, Dept Nucl Med, DK-9000 Aalborg, Denmark Radiologi (creator_code:org_t)
- 2022-03-10
- 2022
- English.
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In: Diagnostics. - : MDPI AG. - 2075-4418. ; 12:3
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https://doi.org/10.3...
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https://uu.diva-port... (primary) (Raw object)
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Abstract
Subject headings
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- Background: The aim of this prospective study was to assess the diagnostic value of nuclear imaging with F-18-FDG PET/CT (FDG PET/CT), combined In-111-WBC/(99)mTc-Nanocoll, and Tc-99m-HDP SPECT/CT (dual-isotope WBC/bone marrow scan) for patients with chronic problems related to knee or hip prostheses (TKA or THA) scheduled by a structured multidisciplinary algorithm.Materials and Methods: Fifty-five patients underwent imaging with Tc-99m-HDP SPECT/CT (bone scan), dual-isotope WBC/bone marrow scan, and FDG PET/CT. The final diagnosis of prosthetic joint infection (PJI) and/or loosening was based on the intraoperative findings and microbiological culture results and the clinical follow-up.Results: The diagnostic performance of dual-isotope WBC/bone marrow SPECT/CT for PJI showed a sensitivity of 100% (CI 0.74-1.00), a specificity of 97% (CI 0.82-1.00), and an accuracy of 98% (CI 0.88-1.00); for PET/CT, the sensitivity, specificity, and accuracy were 100% (CI 0.74-1.00), 71% (CI 0.56-0.90), and 79% (CI 0.68-0.93), respectively.Conclusions: In a standardized prospectively scheduled patient group, the results showed highly specific performance of combined dual-isotope WBC/bone marrow SPECT/CT in confirming chronic PJI. FDG PET/CT has an appropriate accuracy, but the utility of its use in the clinical diagnostic algorithm of suspected PJI needs further evidence.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Radiologi och bildbehandling (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Radiology, Nuclear Medicine and Medical Imaging (hsv//eng)
Keyword
- hybrid imaging
- nuclear imaging
- FDG PET/CT
- labeled leucocyte imaging
- dual-isotope WBC/bone marrow scan
- bone scan
- prosthetic joint infection
- periprosthetic infection
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Aleksyniene, Ram ...
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Iyer, Victor
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Bertelsen, Henri ...
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Nilsson, Majbrit ...
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Khalid, Vesal
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Schonheyder, Hen ...
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Larsen, Lone Hei ...
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Nielsen, Poul To ...
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Kappel, Andreas
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Thomsen, Trine R ...
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Lorenzen, Jan
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Ørsted, Iben
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Simonsen, Ole
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Jordal, Peter Lü ...
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Rasmussen, Sten
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Radiology Nuclea ...
- Articles in the publication
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Diagnostics
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Uppsala University