Search: onr:"swepub:oai:DiVA.org:uu-473970" > The endoplasmic ret...
Fältnamn | Indikatorer | Metadata |
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000 | 03886naa a2200469 4500 | |
001 | oai:DiVA.org:uu-473970 | |
003 | SwePub | |
008 | 220506s2022 | |||||||||||000 ||eng| | |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-4739702 URI |
024 | 7 | a https://doi.org/10.1242/jcs.2590732 DOI |
040 | a (SwePub)uu | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Xie, Beichenu Uppsala universitet,Institutionen för medicinsk cellbiologi4 aut |
245 | 1 0 | a The endoplasmic reticulum-plasma membrane tethering protein TMEM24 is a regulator of cellular Ca2+ homeostasis |
264 | c 2021-12-16 | |
264 | 1 | b The Company of Biologists,c 2022 |
338 | a electronic2 rdacarrier | |
520 | a Endoplasmic reticulum (ER)-plasma membrane (PM) contacts are sites of lipid exchange and Ca2+ transport, and both lipid transport proteins and Ca2+ channels specifically accumulate at these locations. In pancreatic beta-cells, both lipid and Ca2+ signaling are essential for insulin secretion. The recently characterized lipid transfer protein TMEM24 (also known as C2CD2L) dynamically localizes to ER-PM contact sites and provides phosphatidylinositol, a precursor of phosphatidylinositol-4-phosphate [PI(4)P] and phosphatidylinositol 4,5-bisphosphate [PI(4,5)P-2], to the PM. beta-cells lacking TMEM24 exhibit markedly suppressed glucose-induced Ca2+ oscillations and insulin secretion, but the underlying mechanism is not known. We now show that TMEM24 onlyweakly interacts with the PM, and dissociates in response to both diacylglycerol and nanomolar elevations of cytosolic Ca2+. Loss of TMEM24 results in hyper-accumulation of Ca2+ in the ER and in excess Ca2+ entry into mitochondria, with resulting impairment in glucose-stimulated ATP production. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Cell- och molekylärbiologi0 (SwePub)301082 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Cell and Molecular Biology0 (SwePub)301082 hsv//eng |
650 | 7 | a NATURVETENSKAPx Biologix Cellbiologi0 (SwePub)106042 hsv//swe |
650 | 7 | a NATURAL SCIENCESx Biological Sciencesx Cell Biology0 (SwePub)106042 hsv//eng |
653 | a Membrane contact sites | |
653 | a Ca2+ | |
653 | a Insulin secretion | |
653 | a Phosphoinositides | |
653 | a Mitochondria | |
700 | 1 | a Panagiotou, Stylianiu Uppsala universitet,Institutionen för immunologi, genetik och patologi4 aut0 (Swepub:uu)stypa892 |
700 | 1 | a Cen, Jingu Uppsala universitet,Institutionen för medicinsk cellbiologi,Institutionen för kvinnors och barns hälsa,Science for Life Laboratory, SciLifeLab4 aut0 (Swepub:uu)jince383 |
700 | 1 | a Gilon, Patricku Catholic Univ Louvain, Inst Expt & Clin Res IREC, Pole Endocrinol Diabet & Nutr EDIN, Ave Hippocrate 55,B1-55-06, B-1200 Brussels, Belgium.4 aut |
700 | 1 | a Bergsten, Peteru Uppsala universitet,Institutionen för medicinsk cellbiologi,Science for Life Laboratory, SciLifeLab,Pediatrisk inflammations- och metabolismforskning samt barnhälsa4 aut0 (Swepub:uu)peteberg |
700 | 1 | a Idevall Hagren, Olof,d 1980-u Uppsala universitet,Institutionen för medicinsk cellbiologi4 aut0 (Swepub:uu)olide169 |
710 | 2 | a Uppsala universitetb Institutionen för medicinsk cellbiologi4 org |
773 | 0 | t Journal of Cell Scienced : The Company of Biologistsg 135:5q 135:5x 0021-9533x 1477-9137 |
856 | 4 | u https://doi.org/10.1242/jcs.259073y Fulltext |
856 | 4 | u https://uu.diva-portal.org/smash/get/diva2:1656473/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print |
856 | 4 | u https://journals.biologists.com/jcs/article-pdf/135/5/jcs259073/2123759/jcs259073.pdf |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-473970 |
856 | 4 8 | u https://doi.org/10.1242/jcs.259073 |
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