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  • Boone, Sebastiaan C.Leiden Univ, Dept Clin Epidemiol, Med Ctr, Postal Zone C7-P,POB 9600, NL-2300 RC Leiden, Netherlands. (author)

Evaluation of the Value of Waist Circumference and Metabolomics in the Estimation of Visceral Adipose Tissue

  • Article/chapterEnglish2022

Publisher, publication year, extent ...

  • 2022-01-06
  • Oxford University Press (OUP),2022
  • electronicrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:uu-474819
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-474819URI
  • https://doi.org/10.1093/aje/kwab298DOI

Supplementary language notes

  • Language:English
  • Summary in:English

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  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Visceral adipose tissue (VAT) is a strong prognostic factor for cardiovascular disease and a potential target for cardiovascular risk stratification. Because VAT is difficult to measure in clinical practice, we estimated prediction models with predictors routinely measured in general practice and VAT as outcome using ridge regression in 2,501 middle-aged participants from the Netherlands Epidemiology of Obesity study, 2008-2012. Adding waist circumference and other anthropometric measurements on top of the routinely measured variables improved the optimism-adjusted R-2 from 0.50 to 0.58 with a decrease in the root-mean-square error (RMSE) from 45.6 to 41.5 cm(2) and with overall good calibration. Further addition of predominantly lipoprotein-related metabolites from the Nightingale platform did not improve the optimism-corrected R-2 and RMSE. The models were externally validated in 370 participants from the Prospective Investigation of Vasculature in Uppsala Seniors (PIVUS, 2006-2009) and 1,901 participants from the Multi-Ethnic Study of Atherosclerosis (MESA, 2000-2007). Performance was comparable to the development setting in PIVUS (R-2 = 0.63, RMSE = 42.4 cm(2), calibration slope = 0.94) but lower in MESA (R-2 = 0.44, RMSE = 60.7 cm(2), calibration slope = 0.75). Our findings indicate that the estimation of VAT with routine clinical measurements can be substantially improved by incorporating waist circumference but not by metabolite measurements.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • van Smeden, MaartenLeiden Univ, Dept Clin Epidemiol, Med Ctr, Postal Zone C7-P,POB 9600, NL-2300 RC Leiden, Netherlands.;Leiden Univ, Dept Biomed Data Sci, Med Stat & Bioinformat Sect, Med Ctr, Leiden, Netherlands. (author)
  • Rosendaal, Frits R.Leiden Univ, Dept Clin Epidemiol, Med Ctr, Postal Zone C7-P,POB 9600, NL-2300 RC Leiden, Netherlands. (author)
  • le Cessie, SaskiaLeiden Univ, Dept Clin Epidemiol, Med Ctr, Postal Zone C7-P,POB 9600, NL-2300 RC Leiden, Netherlands.;Leiden Univ, Dept Biomed Data Sci, Med Stat & Bioinformat Sect, Med Ctr, Leiden, Netherlands. (author)
  • Groenwold, Rolf H. H.Leiden Univ, Dept Clin Epidemiol, Med Ctr, Postal Zone C7-P,POB 9600, NL-2300 RC Leiden, Netherlands. (author)
  • Jukema, J. WouterLeiden Univ, Dept Cardiol, Med Ctr, Leiden, Netherlands.;Netherlands Heart Inst, Utrecht, Netherlands. (author)
  • van Dijk, Ko WillemsLeiden Univ, Dept Human Genet, Med Ctr, Leiden, Netherlands.;Leiden Univ, Einthoven Lab Expt Vasc Med, Med Ctr, Leiden, Netherlands.;Leiden Univ, Dept Med, Div Endocrinol, Med Ctr, Leiden, Netherlands. (author)
  • Lamb, Hildo J.Leiden Univ, Dept Radiol, Med Ctr, Leiden, Netherlands. (author)
  • Greenland, PhilipNorthwestern Univ, Dept Prevent Med, Chicago, IL 60611 USA. (author)
  • Neeland, Ian J.Univ Hosp Harrington Heart & Vasc Inst, Div Cardiovasc Dis, Cleveland, OH USA.;Case Western Reserve Univ, Sch Med, Div Cardiovasc Dis, Cleveland, OH USA. (author)
  • Allison, Matthew A.Univ Calif San Diego, Dept Family Med & Publ Hlth, Div Prevent Med, San Diego, CA 92103 USA. (author)
  • Criqui, Michael H.Univ Calif San Diego, Dept Family Med & Publ Hlth, Div Prevent Med, San Diego, CA 92103 USA. (author)
  • Budoff, Matthew J.Harbor UCLA Med Ctr, Dept Med, Lundquist Inst, Torrance, CA 90509 USA. (author)
  • Lind, LarsUppsala universitet,Institutionen för medicinska vetenskaper(Swepub:uu)larslind (author)
  • Kullberg, Joel,1979-Uppsala universitet,Geriatrik,Radiologi,Antaros Med AB, Mölndal, Sweden.(Swepub:uu)jokul377 (author)
  • Ahlström, Håkan,1953-Uppsala universitet,Radiologi,Antaros Med AB, Mölndal, Sweden.(Swepub:uu)hakanahl (author)
  • Mook-Kanamori, Dennis O.Leiden Univ, Dept Clin Epidemiol, Med Ctr, Postal Zone C7-P,POB 9600, NL-2300 RC Leiden, Netherlands.;Leiden Univ, Dept Publ Hlth & Primary Care, Med Ctr, Leiden, Netherlands. (author)
  • de Mutsert, ReneeLeiden Univ, Dept Clin Epidemiol, Med Ctr, Postal Zone C7-P,POB 9600, NL-2300 RC Leiden, Netherlands. (author)
  • Leiden Univ, Dept Clin Epidemiol, Med Ctr, Postal Zone C7-P,POB 9600, NL-2300 RC Leiden, Netherlands.Leiden Univ, Dept Clin Epidemiol, Med Ctr, Postal Zone C7-P,POB 9600, NL-2300 RC Leiden, Netherlands.;Leiden Univ, Dept Biomed Data Sci, Med Stat & Bioinformat Sect, Med Ctr, Leiden, Netherlands. (creator_code:org_t)

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  • In:American Journal of Epidemiology: Oxford University Press (OUP)191:5, s. 886-8990002-92621476-6256

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