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International eDelp...
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van Huizen, Astrid M.Department of Dermatology, Amsterdam UMC, University of Amsterdam, Amsterdam Public Health, Infection and Immunity, Amsterdam, the Netherlands
(author)
International eDelphi Study to Reach Consensus on the Methotrexate Dosing Regimen in Patients With Psoriasis
- Article/chapterEnglish2022
Publisher, publication year, extent ...
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American Medical Association (AMA),2022
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printrdacarrier
Numbers
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LIBRIS-ID:oai:DiVA.org:uu-475147
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-475147URI
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https://doi.org/10.1001/jamadermatol.2022.0434DOI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:149228843URI
Supplementary language notes
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Language:English
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Summary in:English
Part of subdatabase
Classification
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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Importance A clear dosing regimen for methotrexate in psoriasis is lacking, and this might lead to a suboptimal treatment. Because methotrexate is affordable and globally available, a uniform dosing regimen could potentially optimize the treatment of patients with psoriasis worldwide.Objective To reach international consensus among psoriasis experts on a uniform dosing regimen for treatment with methotrexate in adult and pediatric patients with psoriasis and identify potential future research topics.Design, Setting, and Participants Between September 2020 and March 2021, a survey study with a modified eDelphi procedure that was developed and distributed by the Amsterdam University Medical Center and completed by 180 participants worldwide (55 [30.6%] resided in non-Western countries) was conducted in 3 rounds. The proposals on which no consensus was reached were discussed in a conference meeting (June 2021). Participants voted on 21 proposals with a 9-point scale (1-3 disagree, 4-6 neither agree nor disagree, 7-9 agree) and were recruited through the Skin Inflammation and Psoriasis International Network and European Academy of Dermatology and Venereology in June 2020. Apart from being a dermatologist/dermatology resident, there were no specific criteria for participation in the survey. The participants worked mainly at a university hospital (97 [53.9%]) and were experienced in treating patients with psoriasis with methotrexate (163 [91.6%] had more than 10 years of experience).Main Outcomes and Measures In a survey with eDelphi procedure, we tried to reach consensus on 21 proposals. Consensus was defined as less than 15% voting disagree (1-3). For the consensus meeting, consensus was defined as less than 30% voting disagree.Results Of 251 participants, 180 (71.7%) completed all 3 survey rounds, and 58 participants (23.1%) joined the conference meeting. Consensus was achieved on 11 proposals in round 1, 3 proposals in round 2, and 2 proposals in round 3. In the consensus meeting, consensus was achieved on 4 proposals. More research is needed, especially for the proposals on folic acid and the dosing of methotrexate for treating subpopulations such as children and vulnerable patients.Conclusions and Relevance In this eDelphi consensus study, consensus was reached on 20 of 21 proposals involving methotrexate dosing in patients with psoriasis. This consensus may potentially be used to harmonize the treatment with methotrexate in patients with psoriasis.
Subject headings and genre
Added entries (persons, corporate bodies, meetings, titles ...)
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Menting, Stef P.Department of Dermatology, OLVG, Amsterdam, the Netherlands
(author)
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Gyulai, RollandDepartment of Dermatology, University of Pécs, Medical School, Venerology and Oncodermatology, Pécs, Hungary
(author)
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Iversen, LarsDepartment of Dermatology, Aarhus University Hospital, Aarhus, Denmark
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van der Kraaij, Gayle E.Department of Dermatology, Amsterdam UMC, University of Amsterdam, Amsterdam Public Health, Infection and Immunity, Amsterdam, the Netherlands
(author)
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Middelkamp-Hup, Maritza A.Department of Dermatology, Amsterdam UMC, University of Amsterdam, Amsterdam Public Health, Infection and Immunity, Amsterdam, the Netherlands
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Warren, Richard B.The Dermatology Centre, Salford Royal NHS Foundation Trust, The Manchester NIHR Biomedical Research Centre, United Kingdom
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Spuls, Phyllis I.Department of Dermatology, Amsterdam UMC, University of Amsterdam, Amsterdam Public Health, Infection and Immunity, Amsterdam, the Netherlands
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Schejtman, Adrián A.Centro Dermatológico Schejtman, Provincia de Buenos Aires, Argentina
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Egeberg, AlexanderDepartment of Dermatology, Bispebjerg Hospital, Copenhagen, Denmark
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Firooz, AlirezaCenter for Research and Training in Skin Diseases and Leprosy, Tehran University of Medical Sciences, Tehran, Iran
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Kumar, Alur S.Apollo Hospital, Secunderabad, Telangana, India
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Oakley, AmandaWaikato District Health Board, University of Auckland, Auckland, New Zealand
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Foulkes, AmyThe Dermatology Centre, Salford Royal NHS Foundation Trust, The Manchester NIHR Biomedical Research Centre, United Kingdom
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Ramos, Andrea Machado CoelhoHospital das Clínicas da Universidade Federal de Minas Gerais, Belo Horizonte, Brazil
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Fougerousse, Anne-ClaireMilitary Teaching Hospital Begin, Saint Mandé, France
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Čarija, AntoanelaSchool of Medicine, University of Split, University Hospital Centre Split, Croatia
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Akman-Karakaş, AyseDepartment of Dermatology and Venerology, Akdeniz University School of Medicine, Antalya, Turkey
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Horváth, BarbaraDepartment of Dermatology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands
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Fábos, BéataDepartment of Dermatology, Teaching Hospital Kaposvar, Kaposvar, Hungary
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Matlock, Benjamin HidalgoUniversity of Costa Rica/Hospital Nacional de Niños, San Pedro Montes de Oca, San Jose Province, Costa Rica
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Claréus, Birgitta WilsonPsoriasis Treatment Wards, Stockholm, Sweden
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Castro, CarlaDermatologist Hospital Universitario Austral, Buenos Aires, Argentina
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Ferrándiz, CarlosDepartment of Dermatology, Hospital universitario Germans Trias i Pujol, Universidad Autónoma de Barcelona, Barcelona, Spain
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Correa, Carolina CortésDermatology Service of La Samaritana University Hospital, Bogotá, Colombia;Pontificia Universidad Javeriana/National University of Colombia, Bogotá, Colombia
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Marchesi, CarolinaProderma, Clínica de la piel, San Juan, Argentina
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Goujon, CatherineDepartment of Immunology and Clinical Allergology, Lyon sud Hospital, Saint-Genis-Laval, France
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Gonzalez, CesarPrivate practice, Bogotá, Colombia
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Maldonado-García, CésarCentro Dermatologico “Dr. Ladislao de la Pascua,” Mexico City, Mexico
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Hong, Chih-hoDepartment of Dermatology and Skin Science, University of British Columbia, Vancouver, British Columbia, Canada
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Griffiths, Christopher E.M.The Dermatology Centre, Salford Royal NHS Foundation Trust, The Manchester NIHR Biomedical Research Centre, United Kingdom,Service de Dermatologie, Hôpital Victor Dupouy, Argenteuil, France
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Vestergaard, ChristianDepartment of Dermatology, Aarhus University Hospital, Aarhus, Denmark
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Echeverría, Christina MarielaInstituto de Rehabilitación Psicofísica, IREP, Buenos Aires, Argentina
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de la Cruz, ClaudiaClinica Dermacross, Santiago, Chile
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Conrad, CurdinDepartment of Dermatology, Lausanne University Hospital CHUV, Lausanne, Switzerland
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Törőcsik, DánielDepartment of Dermatology, Faculty of Medicine, University of Debrecen, Debrecen, Hungary
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Drvar, Daniela LedićDepartment of Dermatology and Venereology, University Hospital Centre Zagreb, School of Medicine University of Zagreb, Croatia
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Balak, DeepakDepartment of Dermatology, Ghent University Hospital, Ghent, Belgium
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Jullien, DenisHospices Civils de Lyon, Hôpital E. Herriot, Service de Dermatologie, Lyon, France
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Appelen, DiebrechtRadboud University Medical Center, Nijmegen, the Netherlands
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Kim, Dong HyunDepartment of Dermatology, CHA Bundang Medical Center, CHA University College of Medicine, Seongnam, Republic of Korea
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de Jong, Elke M.G.J.Radboud University Medical Center, Nijmegen, the Netherlands
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El Gamal, EmadDamietta Faculty of Medicine, Al-Azhar University, Cairo, Egypt
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Laffitte, EmmanuelDepartment of Dermatology, University Hospital of Geneva, Geneva, Switzerland
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Mahé, EmmanuelService de Dermatologie, Hôpital Victor Dupouy, Argenteuil, France
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Sonkoly, EniköUppsala universitet,Dermatologi och venereologi(Swepub:uu)enipi547
(author)
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Colombo, Erika PáezHospital Vargas de Caracas, Venezuela
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Vilarrasa, EvaDermatology Department, Hospital de la Santa Creu i Sant Pau, Universitat Autònoma de Barcelona, Barcelona, Spain
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Willaert, FabienneHôpital ERASME, Université Libre de Bruxelles, Anderlecht, Belgium
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Novoa, Farah D.Private practice, Santiago de Surco, Peru
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Department of Dermatology, Amsterdam UMC, University of Amsterdam, Amsterdam Public Health, Infection and Immunity, Amsterdam, the NetherlandsDepartment of Dermatology, OLVG, Amsterdam, the Netherlands
(creator_code:org_t)
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In:JAMA dermatology: American Medical Association (AMA)158:5, s. 561-5612168-60682168-6084
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van Huizen, Astr ...
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Menting, Stef P.
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Gyulai, Rolland
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Iversen, Lars
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van der Kraaij, ...
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Middelkamp-Hup, ...
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Warren, Richard ...
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Spuls, Phyllis I ...
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Egeberg, Alexand ...
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Firooz, Alireza
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Kumar, Alur S.
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Oakley, Amanda
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Foulkes, Amy
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Ramos, Andrea Ma ...
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Fougerousse, Ann ...
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Čarija, Antoanel ...
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Akman-Karakaş, A ...
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Horváth, Barbara
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Fábos, Béata
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Matlock, Benjami ...
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Claréus, Birgitt ...
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Castro, Carla
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Ferrándiz, Carlo ...
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Correa, Carolina ...
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Marchesi, Caroli ...
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Goujon, Catherin ...
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Gonzalez, Cesar
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Maldonado-García ...
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Hong, Chih-ho
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Griffiths, Chris ...
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Vestergaard, Chr ...
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Echeverría, Chri ...
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de la Cruz, Clau ...
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Conrad, Curdin
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Törőcsik, Dániel
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Drvar, Daniela L ...
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Balak, Deepak
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Jullien, Denis
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Appelen, Diebrec ...
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Kim, Dong Hyun
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de Jong, Elke M. ...
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El Gamal, Emad
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Laffitte, Emmanu ...
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Mahé, Emmanuel
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Sonkoly, Enikö
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Colombo, Erika P ...
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Vilarrasa, Eva
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Willaert, Fabien ...
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Novoa, Farah D.
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JAMA dermatology
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Uppsala University
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Karolinska Institutet