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Human germline gene...
Human germline gene editing. Recommendations of ESHG and ESHRE
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- de Wert, Guido (author)
- Maastricht Univ, Fac Hlth Med & Life Sci, Res Inst GROW, Dept Hlth Eth & Soc, POB 616, NL-6200 MD Maastricht, Netherlands.;Maastricht Univ, Fac Hlth Med & Life Sci, Res Inst CAPHRI, Dept Hlth Eth & Soc, POB 616, NL-6200 MD Maastricht, Netherlands.
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- Pennings, Guido (author)
- Univ Ghent, Bioeth Inst Ghent, Dept Philosophy & Moral Sci, Blandijnberg 2, B-9000 Ghent, Belgium.
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- Clarke, Angus (author)
- Univ Hosp Wales, Inst Med Genet, Heath Pk, Cardiff CF14 4XN, Wales.
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- Eichenlaub-Ritter, Ursula (author)
- Univ Bielefeld, Inst Gene Technol Microbiol, Fac Biol, Postfach 10 01 31, D-33501 Bielefeld, Germany.
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- van El, Carla G. (author)
- Vrije Univ Amsterdam, Med Ctr, Dept Clin Genet, Sect Community Genet, Van Boechorststr 7, NL-1081 BT Amsterdam, Netherlands.;Vrije Univ Amsterdam, Med Ctr, Amsterdam Publ Hlth Res Inst, Van Boechorststr 7, NL-1081 BT Amsterdam, Netherlands.
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- Forzano, Francesca (author)
- Guys & St Thomas NHS Fdn Trust, Guys Hosp, Clin Genet Dept, 7th Floor,Borough Wing, London SE1 9RT, England.
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- Goddijn, Mariette (author)
- Acad Med Ctr, Ctr Reprod Med, Dept Obstet & Gynecol, Meibergdreef 9, NL-1105 AZ Amsterdam, Netherlands.
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- Heindryckx, Bjoern (author)
- Ghent Univ Hosp, Ghent Fertil & Stem Cell Team G FaST, Dept Reprod Med, C Heymanslaan 10, B-9000 Ghent, Belgium.
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- Howard, Heidi Carmen (author)
- Uppsala universitet,Centrum för forsknings- och bioetik
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- Radojkovic, Dragica (author)
- Univ Belgrade, Inst Mol Genet & Genet Engn, Lab Mol Biol, POB 23, Belgrade 11010, Serbia.
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- Rial-Sebbag, Emmanuelle (author)
- Univ Paul Sabatier Toulouse III, Univ Toulouse, INSERM, UMR 1027,Emmanuelle Rial Sebbag, Allees Jules Guesdes 37, F-31073 Toulouse, France.
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- Tarlatzis, Basil C. (author)
- Aristotle Univ Thessaloniki, Sch Med, Dept Obstet & Gynecol 1, 9 Agias Sofias Str, Thessaloniki 54623, Greece.
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- Cornel, Martina C. (author)
- Vrije Univ Amsterdam, Med Ctr, Dept Clin Genet, Sect Community Genet, Van Boechorststr 7, NL-1081 BT Amsterdam, Netherlands.;Vrije Univ Amsterdam, Med Ctr, Amsterdam Publ Hlth Res Inst, Van Boechorststr 7, NL-1081 BT Amsterdam, Netherlands.
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Maastricht Univ, Fac Hlth Med & Life Sci, Res Inst GROW, Dept Hlth Eth & Soc, POB 616, NL-6200 MD Maastricht, Netherlands;Maastricht Univ, Fac Hlth Med & Life Sci, Res Inst CAPHRI, Dept Hlth Eth & Soc, POB 616, NL-6200 MD Maastricht, Netherlands. Univ Ghent, Bioeth Inst Ghent, Dept Philosophy & Moral Sci, Blandijnberg 2, B-9000 Ghent, Belgium. (creator_code:org_t)
- 2018-01-12
- 2018
- English.
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In: HUMAN REPRODUCTION OPEN. - : Oxford University Press (OUP). - 2399-3529. ; 2018:1
- Related links:
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Abstract
Subject headings
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- Technological developments in gene editing raise high expectations for clinical applications, first of all for somatic gene editing but in theory also for germline gene editing (GLGE). GLGE is currently not allowed in many countries. This makes clinical applications in these countries impossible now, even if GLGE would become safe and effective. What were the arguments behind this legislation, and are they still convincing? If a technique can help to avoid serious genetic disorders, in a safe and effective way, would this be a reason to reconsider earlier standpoints? The European Society of Human Reproduction and Embryology (ESHRE) and the European Society of Human Genetics (ESHG) together developed a Background document and Recommendations to inform and stimulate ongoing societal debates. After consulting its membership and experts, this final version of the Recommendations was endorsed by the Executive Committee and the Board of the respective Societies in May 2017. Taking account of ethical arguments, we argue that both basic and pre-clinical research regarding human GLGE can be justified, with conditions. Furthermore, while clinical GLGE would be totally premature, it might become a responsible intervention in the future, but only after adequate pre-clinical research. Safety of the child and future generations is a major concern. Future discussions must also address priorities among reproductive and potential non-reproductive alternatives, such as PGD and somatic editing, if that would be safe and successful. The prohibition of human germline modification, however, needs renewed discussion among relevant stakeholders, including the general public and legislators.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Medicinsk etik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Medical Ethics (hsv//eng)
Keyword
- human germline gene editing
- ESHRE
- ESHG
- ethics
- legislation
- professional policy
- recommendations
- responsible innovation
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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de Wert, Guido
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Pennings, Guido
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Clarke, Angus
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Eichenlaub-Ritte ...
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van El, Carla G.
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Forzano, Frances ...
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Goddijn, Mariett ...
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Heindryckx, Bjoe ...
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Howard, Heidi Ca ...
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Radojkovic, Drag ...
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Rial-Sebbag, Emm ...
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Tarlatzis, Basil ...
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Cornel, Martina ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Health Sciences
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and Medical Ethics
- Articles in the publication
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HUMAN REPRODUCTI ...
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Uppsala University