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HLA-DQ heterodimers in hematopoietic cell transplantation
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- Petersdorf, Effie W. (author)
- Fred Hutchinson Canc Res Ctr, Div Clin Res, 1124 Columbia St, Seattle, WA 98104 USA.;Univ Washington, Dept Med, Seattle, WA USA.
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- Bengtsson, Mats (author)
- Uppsala universitet,Klinisk immunologi
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- Horowitz, Mary (author)
- Ctr Int Blood & Marrow Transplant Res, Milwaukee, WI USA.;Med Coll Wisconsin, Div Hematol & Oncol, Milwaukee, WI 53226 USA.
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- Fred Hutchinson Canc Res Ctr, Div Clin Res, 1124 Columbia St, Seattle, WA 98104 USA;Univ Washington, Dept Med, Seattle, WA USA. Klinisk immunologi (creator_code:org_t)
- American Society of Hematology, 2022
- 2022
- English.
- In: Blood. - : American Society of Hematology. - 0006-4971 .- 1528-0020. ; 139:20, s. 3009-3017
- Journal article (peer-reviewed)
Abstract
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- HLA-DQ heterodimers increase the susceptibility to autoimmune diseases, but their role in hematopoietic cell transplantation is unknown. We tested the hypothesis that outcome after HLA-matched and HLA-DQ-mismatched hematopoietic cell transplantation is influenced by HLA-DQ heterodimers. Heterodimers were defined in 5164 HLA-matched and 520 HLA-DQ-mismatched patients and their transplant donors according to well-established crystallographic criteria. Group 1 (G1) heterodimers are any DQA1*02/03/04/05/06a paired with any DQB1*02/03/040. Group 2 (G2) heterodimers are DQA1*01a paired with any DQB1*05/060. Multivariable models identified significantly higher relapse risk in G1G2 and G2G2 compared with G1G1 HLA-matched patients with malignant disease; risk increased with an increasing number of G2 molecules. In HLA-DQ-mismatched transplantation for malignant diseases, matching or mismatching for G2 increased relapse risk. G2 lowered disease-free survival after both HLA-matched and HLA-DQ-mismatched transplantation. A paradigm based on HLA-DQ heterodimers provides a functional definition of the hematopoietic cell transplantation barrier and a means to lower risks for future patients.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Hematologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Hematology (hsv//eng)
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- Gooley, Ted A.
- Stevenson, Phil
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- Uppsala University
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