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Neutralizing Antibo...
Neutralizing Antibody Titers in Hospitalized Patients with Acute Puumala Orthohantavirus Infection Do Not Associate with Disease Severity
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- Iheozor-Ejiofor, Rommel (author)
- Univ Helsinki, Dept Virol, Med, Helsinki 00014, Finland.
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- Vapalahti, Katariina (author)
- Univ Helsinki, Dept Vet Biosci, Helsinki 00014, Finland.;Helsinki Univ Hosp, Diagnost Ctr, HUSLAB, Virol & Immunol, Helsinki 00029, Finland.
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- Sironen, Tarja (author)
- Univ Helsinki, Dept Virol, Med, Helsinki 00014, Finland.;Univ Helsinki, Dept Vet Biosci, Helsinki 00014, Finland.
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- Levanov, Lev (author)
- Univ Helsinki, Dept Virol, Med, Helsinki 00014, Finland.
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- Hepojoki, Jussi (author)
- Univ Helsinki, Dept Virol, Med, Helsinki 00014, Finland.;Univ Zurich, Vetsuisse Fac, Inst Vet Pathol, CH-8057 Zurich, Switzerland.
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- Lundkvist, Åke (author)
- Uppsala universitet,Institutionen för medicinsk biokemi och mikrobiologi,Uppsala Univ, Zoonosis Sci Ctr, Dept Med Biochem & Microbiol, SE-75105 Uppsala, Sweden.
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- Makela, Satu (author)
- Tampere Univ Hosp, Dept Internal Med, Tampere 33520, Finland.;Tampere Univ, Fac Med & Hlth Technol, Tampere 33014, Finland.
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- Vaheri, Antti (author)
- Univ Helsinki, Dept Virol, Med, Helsinki 00014, Finland.
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- Mustonen, Jukka (author)
- Tampere Univ Hosp, Dept Internal Med, Tampere 33520, Finland.;Tampere Univ, Fac Med & Hlth Technol, Tampere 33014, Finland.
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- Plyusnin, Alexander (author)
- Univ Helsinki, Dept Virol, Med, Helsinki 00014, Finland.
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- Strandin, Tomas M. (author)
- Univ Helsinki, Dept Virol, Med, Helsinki 00014, Finland.
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- Vapalahti, Olli (author)
- Univ Helsinki, Dept Virol, Med, Helsinki 00014, Finland.;Univ Helsinki, Dept Vet Biosci, Helsinki 00014, Finland.;Helsinki Univ Hosp, Diagnost Ctr, HUSLAB, Virol & Immunol, Helsinki 00029, Finland.
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Univ Helsinki, Dept Virol, Med, Helsinki 00014, Finland Univ Helsinki, Dept Vet Biosci, Helsinki 00014, Finland.;Helsinki Univ Hosp, Diagnost Ctr, HUSLAB, Virol & Immunol, Helsinki 00029, Finland. (creator_code:org_t)
- 2022-04-26
- 2022
- English.
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In: Viruses. - : MDPI. - 1999-4915. ; 14:5
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Abstract
Subject headings
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- Nephropathia epidemica (NE), a mild form of haemorrhagic fever with renal syndrome (HFRS), is an acute febrile illness caused by Puumala orthohantavirus (PUUV). NE manifests typically with acute kidney injury (AKI), with a case fatality rate of about 0.1%. The treatment and management of hantavirus infections are mainly supportive, although neutralizing monoclonal antibodies and immune sera therapeutics are under investigation. In order to assess the potential use of antibody therapeutics in NE, we sought to determine the relationship between circulating PUUV neutralizing antibodies, PUUV nucleocapsid protein (N) IgG antibodies, and viral loads with markers of disease severity. The study included serum samples of extensively characterized patient cohorts (n = 116) from Tampere University Hospital, Finland. The results showed that upon hospitalization, most patients already had considerable neutralizing and anti-PUUV-N IgG antibody levels. However, contrary to expectations, neutralizing antibody titers from the first day of hospitalization did not appear to protect from AKI or correlate with more favorable disease outcomes. This indicates that further studies are needed to investigate the applicability of neutralizing antibodies as a therapy for hospitalized NE patients.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Infektionsmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Infectious Medicine (hsv//eng)
Keyword
- nephropathia epidemica
- AKI
- pFRNT
- disease severity
- neutralizing antibody
Publication and Content Type
- ref (subject category)
- art (subject category)
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Iheozor-Ejiofor, ...
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Vapalahti, Katar ...
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Sironen, Tarja
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Levanov, Lev
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Hepojoki, Jussi
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Lundkvist, Åke
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Makela, Satu
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Vaheri, Antti
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Mustonen, Jukka
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Plyusnin, Alexan ...
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Strandin, Tomas ...
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Vapalahti, Olli
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- MEDICAL AND HEALTH SCIENCES
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Uppsala University