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Quality of life and...
Quality of life and late toxicity after short-course radiotherapy followed by chemotherapy or chemoradiotherapy for locally advanced rectal cancer - The RAPIDO trial
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- Dijkstra, Esmee A. (author)
- Univ Groningen, Univ Med Ctr Groningen, Dept Med Oncol, Groningen, Netherlands.
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- Hospers, Geke A. P. (author)
- Univ Groningen, Univ Med Ctr Groningen, Dept Med Oncol, Groningen, Netherlands.
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- Kranenbarg, Elma Meershoek-Klein (author)
- Leiden Univ, Dept Surg, Med Ctr, Leiden, Netherlands.
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- Fleer, Joke (author)
- Univ Groningen, Univ Med Ctr Groningen, Dept Hlth Sci, Sect Hlth Psychol, Groningen, Netherlands.
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- Roodvoets, Annet G. H. (author)
- Leiden Univ, Dept Surg, Med Ctr, Leiden, Netherlands.
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- Bahadoer, Renu R. (author)
- Leiden Univ, Dept Surg, Med Ctr, Leiden, Netherlands.
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- Guren, Marianne G. (author)
- Oslo Univ Hosp, Dept Oncol, Oslo, Norway.
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- Tjalma, Jolien J. J. (author)
- Univ Groningen, Univ Med Ctr Groningen, Dept Gen Practice, Groningen, Netherlands.
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- Putter, Hein (author)
- Leiden Univ, Dept Med Stat & Bioinformat, Med Ctr, Leiden, Netherlands.,Amphia Hosp, Dept Surg, Breda, Netherlands.
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- Crolla, Rogier M. P. H. (author)
- Amphia Hosp, Dept Surg, Breda, Netherlands.,Northwest Clin, Dept Med Oncol, Alkmaar, Netherlands.
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- Hendriks, Mathijs P. (author)
- Northwest Clin, Dept Med Oncol, Alkmaar, Netherlands.
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- Capdevila, Jaume (author)
- Autonomous Univ Barcelona UAB, Vall Hebron Univ Hosp, Vall Hebron Inst Oncol VHIO, Dept Med Oncol, Barcelona, Spain.
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- Radu, Calin, 1969- (author)
- Uppsala universitet,Experimentell och klinisk onkologi
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- van de Velde, Cornelis J. H. (author)
- Leiden Univ, Dept Surg, Med Ctr, Leiden, Netherlands.
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- Nilsson, Per J. (author)
- Karolinska Institutet,Karolinska Univ Hosp, Dept Surg, Stockholm, Sweden.
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- Glimelius, Bengt (author)
- Uppsala universitet,Experimentell och klinisk onkologi
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- van Etten, Boudewijn (author)
- Univ Groningen, Univ Med Ctr Groningen, Dept Surg, Groningen, Netherlands.
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- Marijnen, Corrie A. M. (author)
- Netherlands Canc Inst, Dept Radiat Oncol, Amsterdam, Netherlands.;Leiden Univ, Dept Radiat Oncol, Med Ctr, Leiden, Netherlands.
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Univ Groningen, Univ Med Ctr Groningen, Dept Med Oncol, Groningen, Netherlands Leiden Univ, Dept Surg, Med Ctr, Leiden, Netherlands. (creator_code:org_t)
- Elsevier, 2022
- 2022
- English.
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In: Radiotherapy and Oncology. - : Elsevier. - 0167-8140 .- 1879-0887. ; 171, s. 69-76
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Abstract
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- Background and purpose: The RAPIDO trial demonstrated a decrease in disease-related treatment failure (DrTF) and an increase in pathological complete responses (pCR) in locally advanced rectal cancer (LARC) patients receiving total neoadjuvant treatment (TNT) compared to conventional chemoradiotherapy. This study examines health-related quality of life (HRQL), bowel function, and late toxicity in patients in the trial.Materials and methods: Patients were randomized between short-course radiotherapy followed by pre-operative chemotherapy (EXP), or chemoradiotherapy and optional post-operative chemotherapy (STD). The STD group was divided into patients who did (STD+) and did not (STD-) receive post-operative chemotherapy. Three years after surgery patients received HRQL (EORTC QLQ-C30, QLQ-CR29 and QLQ-CIPN20) and LARS questionnaires. Patients who experienced a DrTF event before the toxicity assessments (6, 12, 24, or 36 months) were excluded from analyses.Results: Of 574 eligible patients, 495 questionnaires were returned (86%) and 453 analyzed (79% com-pleted within time limits). No significant differences were observed between the groups regarding QLQ-C30, QLQ-CR29 or LARS scores. Sensory-related symptoms occurred significantly more often in the EXP group compared to all STD patients, but not compared to STD+ patients. Any toxicity of any grade and grade > 3 toxicity was comparable between the EXP and STD groups at all time-points. Neurotoxicity grade 1-2 occurred significantly more often in the EXP and STD+ group at all time-points compared to the STD-group.Conclusion: The results demonstrate that TNT for LARC, yielding improved DrTF and pCRs, does not com-promise HRQL, bowel functional or results in more grade >3 toxicity compared to standard chemoradio-therapy at three years after surgery in DrTF-free patients.(c) 2022 The Authors. Published by Elsevier B.V. Radiotherapy and Oncology 171 (2022) 69-76 This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Keyword
- Quality of life
- Locally advanced rectal cancer
- Total neoadjuvant treatment
Publication and Content Type
- ref (subject category)
- art (subject category)
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Dijkstra, Esmee ...
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Hospers, Geke A. ...
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Kranenbarg, Elma ...
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Fleer, Joke
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Roodvoets, Annet ...
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Bahadoer, Renu R ...
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Guren, Marianne ...
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Tjalma, Jolien J ...
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Putter, Hein
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Crolla, Rogier M ...
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Hendriks, Mathij ...
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Capdevila, Jaume
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Radu, Calin, 196 ...
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van de Velde, Co ...
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Nilsson, Per J.
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Glimelius, Bengt
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van Etten, Boude ...
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Marijnen, Corrie ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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Radiotherapy and ...
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Uppsala University
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Karolinska Institutet