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  • Wennerberg, JohanLund University,Lunds universitet,Öron-, näs- och halssjukdomar, Lund,Sektion IV,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Huvud- och halscancergruppen,Forskargrupper vid Lunds universitet,Otorhinolaryngology (Lund),Section IV,Department of Clinical Sciences, Lund,Faculty of Medicine,Head and Neck Cancer Research Group,Lund University Research Groups,Skåne University Hospital,Lund Univ, Skane Univ Hosp, Dept ORL Head & Neck Surg, Lund, Sweden. (author)

Results from a prospective, randomised study on (accelerated) preoperative versus (conventional) postoperative radiotherapy in treatment of patients with resectable squamous cell carcinoma of the oral cavity : The ARTSCAN 2 study

  • Article/chapterEnglish2022

Publisher, publication year, extent ...

  • Elsevier,2022
  • electronicrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:uu-478628
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-478628URI
  • https://doi.org/10.1016/j.radonc.2021.11.008DOI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-190146URI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-191960URI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:149838470URI
  • https://lup.lub.lu.se/record/e0fb3028-7d72-4238-bd0d-febace720d2cURI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

Classification

  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Background and purposeAn earlier prospective randomised multicentre study (ARTSCAN) in head and neck cancer patients that compared conventionally fractionated radiotherapy (CF) with accelerated radiotherapy (AF) was inconclusive. In the subgroup of oral cavity squamous cell cancer (OCSCC) a large absolute, but not statistically significant, difference in local control was seen in favour of AF. This difference was more pronounced in resectable tumours. The finding raised the hypothesis that AF could be beneficial for OCSCC patients. In addition, the longstanding controversy on pre- or postoperative radiotherapy was addressed.Materials and methodsPatients with OCSCC, judged to withstand and likely benefit from combined therapy, were recruited. Subjects were randomised to either preoperative AF with 43 fractions given as a concomitant boost with two fractions/day to the tumour bearing volume to a total dose of 68 Gy in 4.5 weeks followed by surgery, or primary surgery with postoperative CF, total dose 60 or 66 Gy in 6–7 weeks. For patients whose tumours had high-risk features, 66 Gy and concomitant cisplatin was prescribed.Results250 patients were randomised. Median follow-up was 5 years for locoregional control (LRC) and 9 years for overall survival (OS). There were no statistically significant differences between the two treatment arms regarding LRC and OS. LRC at five years was 73% (95% CI, 65–82) in preoperative AF and 78% (95% CI, 70–85) in postoperative CF.Toxicity was more pronounced in preoperative AF.ConclusionThis study does not support that AF prior to surgery improves outcome in oral cavity cancer compared with postoperative CF.

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  • Gebre-Medhin, MariaLund University,Lunds universitet,Huvud- och halscancergruppen,Forskargrupper vid Lunds universitet,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Systemisk strålterapi,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Head and Neck Cancer Research Group,Lund University Research Groups,LUCC: Lund University Cancer Centre,Other Strong Research Environments,Systemic radiation therapy,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine,Skåne University Hospital,Lund Univ, Skane Univ Hosp, Dept Hematol Oncol & Radiat Phys, Lund, Sweden.(Swepub:lu)med-mgi (author)
  • Nilsson, PerLund University,Lunds universitet,Medicinsk strålningsfysik, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Radiotherapy Physics,Forskargrupper vid Lunds universitet,Medical Radiation Physics, Lund,Section V,Department of Clinical Sciences, Lund,Faculty of Medicine,Lund University Research Groups,Skåne University Hospital,Lund Univ, Skane Univ Hosp, Dept Hematol Oncol & Radiat Phys, Lund, Sweden.(Swepub:lu)rafy-per (author)
  • Brun, EvaLund University,Lunds universitet,Huvud- och halscancergruppen,Forskargrupper vid Lunds universitet,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Systemisk strålterapi,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Head and Neck Cancer Research Group,Lund University Research Groups,LUCC: Lund University Cancer Centre,Other Strong Research Environments,Systemic radiation therapy,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine,Skåne University Hospital,Lund Univ, Skane Univ Hosp, Dept Hematol Oncol & Radiat Phys, Lund, Sweden.(Swepub:lu)onk-ebr (author)
  • Kjellén, ElisabethLund University,Lunds universitet,Huvud- och halscancergruppen,Forskargrupper vid Lunds universitet,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Systemisk strålterapi,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Head and Neck Cancer Research Group,Lund University Research Groups,LUCC: Lund University Cancer Centre,Other Strong Research Environments,Systemic radiation therapy,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine,Skåne University Hospital,Lund Univ, Skane Univ Hosp, Dept Hematol Oncol & Radiat Phys, Lund, Sweden.(Swepub:lu)onk-ekj (author)
  • Carlwig, KristinLund University,Lunds universitet,Öron-, näs- och halssjukdomar, Lund,Sektion IV,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Huvud- och halscancergruppen,Forskargrupper vid Lunds universitet,Otorhinolaryngology (Lund),Section IV,Department of Clinical Sciences, Lund,Faculty of Medicine,Head and Neck Cancer Research Group,Lund University Research Groups,Skåne University Hospital,Lund Univ, Skane Univ Hosp, Dept ORL Head & Neck Surg, Lund, Sweden.(Swepub:lu)kr7585ca (author)
  • Reizenstein, JohanLinköpings universitet,Institutionen för biomedicinska och kliniska vetenskaper,Medicinska fakulteten,Örebro University Hospital,Örebro Univ Hosp, Dept Oncol, Örebro, Sweden.(Swepub:liu)n/a (author)
  • Kristiansson, StefanÖrebro Univ Hosp, Dept Otolaryngol, Örebro, Sweden.,Department of Otolaryngology, Örebro University Hospital, Sweden (author)
  • Söderkvist, KarinUmeå University,Umeå universitet,Onkologi,Department of Radiation Sciences, Oncology, Umeå University,Umeå Univ, Dept Radiat Sci, Umeå, Sweden.(Swepub:umu)kansom97 (author)
  • Wahlgren, MagnusUmeå University,Umeå universitet,Öron- näs- och halssjukdomar,Department of Clinical Sciences, Otolaryngology Umeå University,Umeå Univ, Dept Clin Sci, Otolaryngol, Umeå, Sweden.(Swepub:umu)mawa0088 (author)
  • Zackrisson, BjörnUmeå University,Umeå universitet,Onkologi,Department of Radiation Sciences, Oncology, Umeå University,Umeå Univ, Dept Radiat Sci, Umeå, Sweden.(Swepub:umu)bjza0002 (author)
  • Högmo, AndersKarolinska Inst, Dept Clin Sci Intervent & Technol, Otorhinolaryngol Head & Neck Surg, Stockholm, Sweden. (author)
  • Hammarstedt-Nordenvall, LalleKarolinska Institutet,Karolinska Inst, Dept Clin Sci Intervent & Technol, Otorhinolaryngol Head & Neck Surg, Stockholm, Sweden. (author)
  • Sjödin, HelenaKarolinska Univ Hosp, Theme Canc, Stockholm, Sweden. (author)
  • Wickart-Johansson, GunKarolinska Univ Hosp, Theme Canc, Stockholm, Sweden. (author)
  • Farnebo, Lovisa,1973-Linköpings universitet,Avdelningen för sinnesorgan och kommunikation,Medicinska fakulteten,Region Östergötland, Hand- och plastikkirurgiska kliniken US,ARTSCAN study group,Linköping Univ, Dept Biomed & Clin Sci, Linköping, Sweden.(Swepub:liu)lovfa06 (author)
  • Rzpecki, JanLinköping Univ Hosp, Dept Oncol, Linköping, Sweden. (author)
  • Lödén, BrittaKarlstad Cent Hosp, Dept Oncol, Uppsala, Sweden. (author)
  • Cederblad, LenaUppsala universitet,Experimentell och klinisk onkologi(Swepub:uu)lenacede (author)
  • Ekberg, TomasUppsala universitet,Öron-, näs- och halssjukdomar(Swepub:uu)thekb676 (author)
  • Bergström, StefanGävle Cent Hosp, Dept Oncol, Gävle, Sweden. (author)
  • Öron-, näs- och halssjukdomar, LundSektion IV (creator_code:org_t)

Related titles

  • In:Radiotherapy and Oncology: Elsevier166, s. 26-320167-81401879-0887

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