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Obesity II :
Obesity II : Establishing causal links between chemical exposures and obesity
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- Heindel, Jerrold J. (author)
- Hlth Environm & Endocrine Disruptor Strategies, Commonweal, Bolinas, CA 92924 USA.
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- Howard, Sarah (author)
- Hlth Environm & Endocrine Disruptor Strategies, Commonweal, Bolinas, CA 92924 USA.
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- Agay-Shay, Keren (author)
- Univ Paris, Dept Syst Biol & Bioinformat, INSERM, T3S, Paris, France.
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- Arrebola, Juan P. (author)
- Univ Bordeaux, Dept Life & Hlth Sci, INSERM, Pessac, France.
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- Audouze, Karine (author)
- Univ Paris, Dept Biochem, INSERM, T3S, F-75006 Paris, France.
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- Babin, Patrick J. (author)
- Univ Louisville, Div Gastroenterol Hepatol & Nutr, Louisville, KY 40402 USA.
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- Barouki, Robert (author)
- Univ South Carolina, Environm Hlth & Dis Lab, Columbia, SC 29208 USA.
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- Bansal, Amita (author)
- Univ Cote Azur, Obstet & Gynecol, Cote Azur, France.
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- Blanc, Etienne (author)
- Univ South Carolina, Environm Hlth & Dis Lab, Columbia, SC 29208 USA.
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- Cave, Matthew C. (author)
- Texas A&M Univ, Coll Pharm, College Stn, TX 77843 USA.
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- Chatterjee, Saurabh (author)
- Univ Bari Aldo Moro, Dept Endocrinol, Bari, Italy.
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- Chevalier, Nicolas (author)
- East Carolina Univ, Brody Sch Med, Greenville, NC 27834 USA.
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- Choudhury, Mahua (author)
- Queens Univ, Inst Global Food Secur, Sch Biol Sci, Belfast, North Ireland.
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- Collier, David (author)
- Univ Stirling, Occupat & Environm Hlth Res Grp, Stirling, Scotland.
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- Connolly, Lisa (author)
- Bar Ilan Univ, Azrieli Fac Med, Hlth & Environm Res HER Lab, Ramat Gan, Israel.
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Coumoul, Xavier (author)
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- Garruti, Gabriella (author)
- Publ Hlth Univ Granada, Dept Prevent Med, Granada, Spain.
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- Gilbertson, Michael (author)
- Australian Natl Univ, Coll Hlth & Med, Canberra, Australia.
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- Hoepner, Lori A. (author)
- SUNY Downstate Hlth Sci Univ, Sch Publ Hlth, Dept Environm & Occupat Hlth Sci, Brooklyn, NY 11203 USA.
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- Holloway, Alison C. (author)
- McMaster Univ, Dept Obstet & Gynecol, Ontario, CA USA.
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- Howell Iii, George (author)
- Univ Louisville, Div Gastroenterol Hepatol & Nutr, Louisville, KY 40402 USA.;Univ Cote Azur, Obstet & Gynecol, Cote Azur, France.;Mississippi State Univ, Ctr Environm Hlth Sci, Starkville, MS 39762 USA.
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- Kassotis, Christopher D. (author)
- Univ Louisville, Div Gastroenterol Hepatol & Nutr, Louisville, KY 40402 USA.;Univ Cote Azur, Obstet & Gynecol, Cote Azur, France.;Wayne State Univ, Inst Environm Hlth Sci, Dept Pharmacol, Detroit, MI 48202 USA.
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- Kay, Mathew K. (author)
- Univ Louisville, Div Gastroenterol Hepatol & Nutr, Louisville, KY 40402 USA.;Univ Cote Azur, Obstet & Gynecol, Cote Azur, France.
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- Kim, Min Ji (author)
- Univ Louisville, Div Gastroenterol Hepatol & Nutr, Louisville, KY 40402 USA.;Univ Cote Azur, Obstet & Gynecol, Cote Azur, France.;Sorbonne Paris Nord Univ, INSERM U1124 (T3S), Bobigny, Paris, France.
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- Lagadic-Gossmann, Dominique (author)
- Univ Paris, Dept Biochem, INSERM, T3S, F-75006 Paris, France.;Univ Louisville, Div Gastroenterol Hepatol & Nutr, Louisville, KY 40402 USA.;Univ Cote Azur, Obstet & Gynecol, Cote Azur, France.;Univ Rennes, INSERM EHESP, IRSET UMR 5S 1085, F-35000 Rennes, France.
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- Langouet, Sophie (author)
- Univ Paris, Dept Biochem, INSERM, T3S, F-75006 Paris, France.;Univ Louisville, Div Gastroenterol Hepatol & Nutr, Louisville, KY 40402 USA.;Univ Cote Azur, Obstet & Gynecol, Cote Azur, France.;Univ Rennes, INSERM EHESP, IRSET UMR 5S 1085, F-35000 Rennes, France.
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- Legrand, Antoine (author)
- Univ Louisville, Div Gastroenterol Hepatol & Nutr, Louisville, KY 40402 USA.;Univ Cote Azur, Obstet & Gynecol, Cote Azur, France.
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- Li, Zhuorui (author)
- Univ Louisville, Div Gastroenterol Hepatol & Nutr, Louisville, KY 40402 USA.;Univ Cote Azur, Obstet & Gynecol, Cote Azur, France.;Univ Calif Irvine, Dept Dev & Cell Biol, Irvine, CA 92697 USA.
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- Le Mentec, Helene (author)
- Univ Louisville, Div Gastroenterol Hepatol & Nutr, Louisville, KY 40402 USA.;Univ Cote Azur, Obstet & Gynecol, Cote Azur, France.
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- Lind, Lars (author)
- Uppsala universitet,Klinisk epidemiologi,Univ Louisville, Div Gastroenterol Hepatol & Nutr, Louisville, KY 40402 USA.;Univ Cote Azur, Obstet & Gynecol, Cote Azur, France.
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- Lind, P. Monica, 1957- (author)
- Uppsala universitet,Arbets- och miljömedicin,Univ Louisville, Div Gastroenterol Hepatol & Nutr, Louisville, KY 40402 USA.;Univ Cote Azur, Obstet & Gynecol, Cote Azur, France.
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- Lustig, Robert H. (author)
- Univ Louisville, Div Gastroenterol Hepatol & Nutr, Louisville, KY 40402 USA.;Univ Cote Azur, Obstet & Gynecol, Cote Azur, France.;Univ Calif San Francisco, Dept Pediat, Div Endocrinol, San Francisco, CA 94143 USA.
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- Martin-Chouly, Corinne (author)
- Univ Louisville, Div Gastroenterol Hepatol & Nutr, Louisville, KY 40402 USA.;Univ Cote Azur, Obstet & Gynecol, Cote Azur, France.
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- Kos, Vesna Munic (author)
- Karolinska Institutet,Univ Louisville, Div Gastroenterol Hepatol & Nutr, Louisville, KY 40402 USA.;Univ Cote Azur, Obstet & Gynecol, Cote Azur, France.;Karolinska Inst, Dept Physiol & Pharmacol, Solna, Sweden.
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- Podechard, Normand (author)
- Univ Louisville, Div Gastroenterol Hepatol & Nutr, Louisville, KY 40402 USA.;Univ Cote Azur, Obstet & Gynecol, Cote Azur, France.
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- Roepke, Troy A. (author)
- Univ Louisville, Div Gastroenterol Hepatol & Nutr, Louisville, KY 40402 USA.;Univ Cote Azur, Obstet & Gynecol, Cote Azur, France.;Rutgers State Univ, Sch Environm & Biol Sci, Dept Anim Sci, New Brunswick, NJ 08901 USA.
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- Sargis, RobertM. (author)
- Univ Louisville, Div Gastroenterol Hepatol & Nutr, Louisville, KY 40402 USA.;Univ Cote Azur, Obstet & Gynecol, Cote Azur, France.;Univ Illinois, Div Endocrinol Diabet & Metab, Chicago, IL 60612 USA.
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- Starling, Anne (author)
- Univ Louisville, Div Gastroenterol Hepatol & Nutr, Louisville, KY 40402 USA.;Univ Cote Azur, Obstet & Gynecol, Cote Azur, France.;Univ North Carolina Chapel Hill, Dept Epidemiol, Chapel Hill, NC 27599 USA.
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- Tomlinson, Craig R. (author)
- Univ Louisville, Div Gastroenterol Hepatol & Nutr, Louisville, KY 40402 USA.;Univ Cote Azur, Obstet & Gynecol, Cote Azur, France.;Norris Cotton Canc Ctr, Geisel Sch Med Dartmouth, Dept Mol & Syst Biol, Lebanon, NH 03756 USA.
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- Touma, Charbel (author)
- Univ Louisville, Div Gastroenterol Hepatol & Nutr, Louisville, KY 40402 USA.;Univ Cote Azur, Obstet & Gynecol, Cote Azur, France.
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- Vondracek, Jan (author)
- Univ Paris, Dept Syst Biol & Bioinformat, INSERM, T3S, Paris, France.;Univ Louisville, Div Gastroenterol Hepatol & Nutr, Louisville, KY 40402 USA.;Univ Cote Azur, Obstet & Gynecol, Cote Azur, France.;Inst Biophys Czech Acad Sci, Dept Cytokinet, Brno, Czech Republic.
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- Saal, Frederick vom (author)
- Univ Bordeaux, Dept Life & Hlth Sci, INSERM, Pessac, France.;Univ Cote Azur, Obstet & Gynecol, Cote Azur, France.;Univ Missouri, Div Biol Sci, Columbia, MO 65211 USA.
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- Blumberg, Bruce (author)
- Univ Louisville, Div Gastroenterol Hepatol & Nutr, Louisville, KY 40402 USA.;Univ Cote Azur, Obstet & Gynecol, Cote Azur, France.
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Hlth Environm & Endocrine Disruptor Strategies, Commonweal, Bolinas, CA 92924 USA Univ Paris, Dept Syst Biol & Bioinformat, INSERM, T3S, Paris, France. (creator_code:org_t)
- Elsevier, 2022
- 2022
- English.
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In: Biochemical Pharmacology. - : Elsevier. - 0006-2952 .- 1356-1839 .- 1873-2968. ; 199
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
Close
- Obesity is a multifactorial disease with both genetic and environmental components. The prevailing view is that obesity results from an imbalance between energy intake and expenditure caused by overeating and insufficient exercise. We describe another environmental element that can alter the balance between energy intake and energy expenditure: obesogens. Obesogens are a subset of environmental chemicals that act as endocrine disruptors affecting metabolic endpoints. The obesogen hypothesis posits that exposure to endocrine disruptors and other chemicals can alter the development and function of the adipose tissue, liver, pancreas, gastrointestinal tract, and brain, thus changing the set point for control of metabolism. Obesogens can determine how much food is needed to maintain homeostasis and thereby increase the susceptibility to obesity. The most sensitive time for obesogen action is in utero and early childhood, in part via epigenetic programming that can be transmitted to future generations. This review explores the evidence supporting the obesogen hypothesis and highlights knowledge gaps that have prevented widespread acceptance as a contributor to the obesity pandemic. Critically, the obesogen hypothesis changes the narrative from curing obesity to preventing obesity.
Subject headings
- NATURVETENSKAP -- Biologi -- Biokemi och molekylärbiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Biochemistry and Molecular Biology (hsv//eng)
Keyword
- Obesogen
- Adipocyte differentiation
- Weight gain
- Obesity
- Endocrine disruptor
Publication and Content Type
- ref (subject category)
- for (subject category)
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- By the author/editor
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Heindel, Jerrold ...
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Howard, Sarah
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Agay-Shay, Keren
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Arrebola, Juan P ...
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Audouze, Karine
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Babin, Patrick J ...
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show more...
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Barouki, Robert
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Bansal, Amita
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Blanc, Etienne
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Cave, Matthew C.
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Chatterjee, Saur ...
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Chevalier, Nicol ...
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Choudhury, Mahua
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Collier, David
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Connolly, Lisa
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Coumoul, Xavier
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Garruti, Gabriel ...
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Gilbertson, Mich ...
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Hoepner, Lori A.
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Holloway, Alison ...
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Howell Iii, Geor ...
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Kassotis, Christ ...
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Kay, Mathew K.
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Kim, Min Ji
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Lagadic-Gossmann ...
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Langouet, Sophie
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Legrand, Antoine
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Li, Zhuorui
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Le Mentec, Helen ...
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Lind, Lars
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Lind, P. Monica, ...
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Lustig, Robert H ...
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Martin-Chouly, C ...
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Kos, Vesna Munic
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Podechard, Norma ...
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Roepke, Troy A.
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Sargis, RobertM.
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Starling, Anne
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Tomlinson, Craig ...
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Touma, Charbel
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Vondracek, Jan
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Saal, Frederick ...
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Blumberg, Bruce
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- About the subject
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- NATURAL SCIENCES
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NATURAL SCIENCES
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and Biological Scien ...
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and Biochemistry and ...
- Articles in the publication
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Biochemical Phar ...
- By the university
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Uppsala University
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Karolinska Institutet