Search: onr:"swepub:oai:DiVA.org:uu-479422" >
Loss of function mu...
Loss of function mutations of BCOR in classical Hodgkin lymphoma
-
- Giefing, Maciej (author)
- Polish Acad Sci, Inst Human Genet, Strzeszynska 32, PL-60479 Poznan, Poland.;Christian Albrechts Univ Kiel, Inst Human Genet, Kiel, Germany.;Univ Hosp Schleswig Holstein, Kiel, Germany.
-
- Gearhart, Micah D. (author)
- Univ Minnesota, Masonic Canc Ctr, Dept Genet Cell Biol & Dev, Minneapolis, MN USA.;Univ Minnesota, Dev Biol Ctr, Minneapolis, MN USA.
-
- Schneider, Markus (author)
- Univ Duisburg Essen, Med Fac, Inst Cell Biol Canc Res, Essen, Germany.;Deutsch Konsortium Translat Krebsforsch DKTK, Heidelberg, Germany.;Univ Childrens Hosp Essen, Dept Pediat Hematol & Oncol, Essen, Germany.
-
show more...
-
- Overbeck, Birte (author)
- Christian Albrechts Univ Kiel, Inst Human Genet, Kiel, Germany.;Univ Hosp Schleswig Holstein, Kiel, Germany.
-
- Klapper, Wolfram (author)
- Christian Albrechts Univ Kiel, Dept Pathol, Haematopathol Sect, Kiel, Germany.;Christian Albrechts Univ Kiel, Lymph Node Registry, Kiel, Germany.
-
- Hartmann, Sylvia (author)
- Goethe Univ Frankfurt, Dr Senckenberg Inst Pathol, Med Sch, Reference & Consultant Ctr Lymph Node & Lymphoma, Frankfurt, Germany.
-
- Ustaszewski, Adam (author)
- Polish Acad Sci, Inst Human Genet, Strzeszynska 32, PL-60479 Poznan, Poland.
-
- Weniger, Marc A. (author)
- Univ Duisburg Essen, Med Fac, Inst Cell Biol Canc Res, Essen, Germany.;Deutsch Konsortium Translat Krebsforsch DKTK, Heidelberg, Germany.
-
- Wiehle, Laura (author)
- Univ Ulm, Inst Human Genet, Ulm, Germany.;Univ Ulm, Med Ctr, Ulm, Germany.
-
- Hansmann, Martin-Leo (author)
- Goethe Univ Frankfurt, Dr Senckenberg Inst Pathol, Med Sch, Reference & Consultant Ctr Lymph Node & Lymphoma, Frankfurt, Germany.
-
- Melnick, Ari (author)
- Weill Cornell Med, Dept Med, Div Hematol Oncol, New York, NY USA.
-
- Beguelin, Wendy (author)
- Weill Cornell Med, Dept Med, Div Hematol Oncol, New York, NY USA.
-
- Sundström, Christer (author)
- Uppsala universitet,Klinisk och experimentell patologi
-
- Küppers, Ralf (author)
- Univ Duisburg Essen, Med Fac, Inst Cell Biol Canc Res, Essen, Germany.;Deutsch Konsortium Translat Krebsforsch DKTK, Heidelberg, Germany.
-
- Bardwell, Vivian J. (author)
- Univ Minnesota, Masonic Canc Ctr, Dept Genet Cell Biol & Dev, Minneapolis, MN USA.;Univ Minnesota, Dev Biol Ctr, Minneapolis, MN USA.
-
- Siebert, Reiner (author)
- Christian Albrechts Univ Kiel, Inst Human Genet, Kiel, Germany.;Univ Hosp Schleswig Holstein, Kiel, Germany.;Univ Ulm, Inst Human Genet, Ulm, Germany.;Univ Ulm, Med Ctr, Ulm, Germany.
-
show less...
-
Polish Acad Sci, Inst Human Genet, Strzeszynska 32, PL-60479 Poznan, Poland;Christian Albrechts Univ Kiel, Inst Human Genet, Kiel, Germany.;Univ Hosp Schleswig Holstein, Kiel, Germany. Univ Minnesota, Masonic Canc Ctr, Dept Genet Cell Biol & Dev, Minneapolis, MN USA.;Univ Minnesota, Dev Biol Ctr, Minneapolis, MN USA. (creator_code:org_t)
- 2021-12-27
- 2022
- English.
-
In: Leukemia and Lymphoma. - : Informa UK Limited. - 1042-8194 .- 1029-2403. ; 63:5, s. 1080-1090
- Related links:
-
https://urn.kb.se/re...
-
show more...
-
https://doi.org/10.1...
-
show less...
Abstract
Subject headings
Close
- BCOR is a component of a variant Polycomb repressive complex 1 (PRC1.1). PRC1 and PRC2 complexes together constitute a major gene regulatory system critical for appropriate cellular differentiation. The gene is upregulated in germinal center (GC) B cells and mutated in a number of hematologic malignancies. We report BCOR inactivating alterations in 4/7 classic Hodgkin lymphoma (cHL) cell lines, subclonal somatic mutations in Hodgkin and Reed-Sternberg (HRS) cells of 4/10 cHL cases, and deletions in HRS cells of 7/17 primary cHL cases. In mice, conditional loss of Bcor driven by AID-Cre in GC B cells resulted in gene expression changes of 46 genes (>2-fold) including upregulated Lef1 that encodes a transcription factor responsible for establishing T-cell identity and Il9r (interleukin-9 receptor), an important member of the cytokine network in cHL. Our findings suggest a role for BCOR loss in cHL pathogenesis and GC-B cell homeostasis.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Keyword
- Classical Hodgkin lymphoma
- microdissection
- BCOR
- Polycomb
- PRC1
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database
- By the author/editor
-
Giefing, Maciej
-
Gearhart, Micah ...
-
Schneider, Marku ...
-
Overbeck, Birte
-
Klapper, Wolfram
-
Hartmann, Sylvia
-
show more...
-
Ustaszewski, Ada ...
-
Weniger, Marc A.
-
Wiehle, Laura
-
Hansmann, Martin ...
-
Melnick, Ari
-
Beguelin, Wendy
-
Sundström, Chris ...
-
Küppers, Ralf
-
Bardwell, Vivian ...
-
Siebert, Reiner
-
show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Clinical Medicin ...
-
and Cancer and Oncol ...
- Articles in the publication
-
Leukemia and Lym ...
- By the university
-
Uppsala University