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Biomarkers of brain...
Biomarkers of brain injury after cardiac arrest; a statistical analysis plan from the TTM2 trial biobank investigators
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- Moseby-Knappe, Marion (author)
- Lund University,Lunds universitet,Neurologi, Lund,Sektion IV,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Brain Injury After Cardiac Arrest,Forskargrupper vid Lunds universitet,Neurologiska skador vid akut aortadissektion typ A,Neurology, Lund,Section IV,Department of Clinical Sciences, Lund,Faculty of Medicine,Lund University Research Groups,Neurological injury in acute type A aortic dissection
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- Levin, Helena (author)
- Lund University,Lunds universitet,Anestesiologi och intensivvård,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Centrum för hjärtstopp,Forskargrupper vid Lunds universitet,Anesthesiology and Intensive Care,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine,Center for cardiac arrest,Lund University Research Groups
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- Blennow, Kaj (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
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- Ullen, Susann (author)
- Skane Univ Hosp, Clin Studies Sweden Forum South, Lund, Sweden.,Skåne University Hospital
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- Zetterberg, Henrik (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
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- Lilja, Gisela (author)
- Lund University,Lunds universitet,Neurologi, Lund,Sektion IV,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Centrum för hjärtstopp,Forskargrupper vid Lunds universitet,Brain Injury After Cardiac Arrest,Neurology, Lund,Section IV,Department of Clinical Sciences, Lund,Faculty of Medicine,Center for cardiac arrest,Lund University Research Groups
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- Dankiewicz, Josef (author)
- Lund University,Lunds universitet,Kardiologi,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Cardiology,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine
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- Jakobsen, Janus Christian (author)
- Ctr Clin Intervent Res, Copenhagen Trial Unit, Copenhagen, Denmark.;Univ Southern Denmark, Fac Hlth Sci, Dept Reg Hlth Res, Odense, Denmark.,Copenhagen University Hospital,University of Southern Denmark
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- Lagebrant, Alice (author)
- Lund University,Lunds universitet,Neurologi, Lund,Sektion IV,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Brain Injury After Cardiac Arrest,Forskargrupper vid Lunds universitet,Neurology, Lund,Section IV,Department of Clinical Sciences, Lund,Faculty of Medicine,Lund University Research Groups
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- Friberg, Hans (author)
- Lund University,Lunds universitet,Anestesiologi och intensivvård,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Centrum för hjärtstopp,Forskargrupper vid Lunds universitet,SWECRIT,Anesthesiology and Intensive Care,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine,Center for cardiac arrest,Lund University Research Groups
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- Nichol, Alistair (author)
- Univ Coll Dublin, Clin Res Ctr, St Vincents Univ Hosp Dublin, Dublin, Ireland.;Monash Univ, Australian & New Zealand Intens Care Res Ctr, Melbourne, Vic, Australia.;Alfred Hosp, Intens Care Unit, Melbourne, Vic, Australia.,Monash University,Alfred Hospital,St Vincent's University Hospital
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- Ainschough, Kate (author)
- Univ Coll Dublin, Clin Res Ctr, St Vincents Univ Hosp Dublin, Dublin, Ireland.,St Vincent's University Hospital
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- Eastwood, Glenn M. (author)
- Austin Hosp, Dept Intens Care, Melbourne, Vic, Australia.;Monash Univ, Australian & New Zealand Intens Care Res Ctr, Sch Publ Hlth & Prevent Med, Melbourne, Vic, Australia.,Austin Hospital,Monash University
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- Wise, Matt P. (author)
- Univ Hosp Wales, Adult Crit Care, Cardiff, Wales.,University Hospital of Wales
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- Thomas, Matthew (author)
- Univ Hosp, Intens Care Unit, Bristol, England.;Univ Hosp, Intens Care Unit, Weston, England.,University Hospitals Bristol NHS Foundation Trust
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- Keeble, Thomas (author)
- MSE, Essex Cardiothorac Ctr, Basildon, Essex, England.;Anglia Ruskin Sch Med, MTRC, Chelmsford, Essex, England.,The Essex Cardiothoracic Centre,Anglia Ruskin University
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- Cariou, Alain (author)
- Paris Cite Univ, Cochin Hosp, AP HP, Med Intens Care Unit, Paris, France.,Cochin Hospital
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- Leithner, Christoph (author)
- Charite Univ Med Berlin, Dept Neurol, AG Emergency & Crit Care Neurol, Campus Virchow Klinikum, Berlin, Germany.,Charité - University Medicine Berlin
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- Rylander, Christian (author)
- Uppsala University,Uppsala universitet,Anestesiologi och intensivvård
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- Düring, Joachim (author)
- Lund University,Lunds universitet,Anestesiologi och intensivvård,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Anesthesiology and Intensive Care,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine
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- Belohlavek, Jan (author)
- Charles Univ Prague, Fac Med 1, Dept Med 2, Prague, Czech Republic.;Gen Univ Hosp, Prague, Czech Republic.,General University Hospital in Prague
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- Grejs, Anders (author)
- Aarhus Univ Hosp, Dept Anaesthesiol & Intens Care Med, Aarhus, Denmark.;Aarhus Univ, Dept Clin Med, Aarhus, Denmark.,Aarhus University Hospital
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- Borgquist, Ola (author)
- Lund University,Lunds universitet,Anestesiologi och intensivvård,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Klinisk forskning inom anestesi och intensivvårdsmedicin,Forskargrupper vid Lunds universitet,Anesthesiology and Intensive Care,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine,Clinical Research in Anaesthesia and Intensive Care Medicine,Lund University Research Groups
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- Undén, Johan (author)
- Lund University,Lunds universitet,Anestesiologi och intensivvård,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Forskargrupper vid Lunds universitet,Anesthesiology and Intensive Care,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine,Anaesthesiology and Intensive Care Medicine,Lund University Research Groups
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- Simon, Maryline (author)
- Roche Diagnost Int AG, Clin Dev Dept, Rotkreuz, Switzerland.,Roche Diagnostics International
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- Rolny, Vinzent (author)
- Roche Diagnost Int AG, Biostat Dept, Rotkreuz, Switzerland.,Roche Diagnostics International
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- Piehler, Alex (author)
- Roche Diagnost Int AG, Biostat Dept, Rotkreuz, Switzerland.,Roche Diagnostics International
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- Cronberg, Tobias (author)
- Lund University,Lunds universitet,Neurologi, Lund,Sektion IV,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Centrum för hjärtstopp,Forskargrupper vid Lunds universitet,Brain Injury After Cardiac Arrest,Neurology, Lund,Section IV,Department of Clinical Sciences, Lund,Faculty of Medicine,Center for cardiac arrest,Lund University Research Groups
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- Nielsen, Niklas (author)
- Lund University,Lunds universitet,Anestesiologi och intensivvård,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Kliniska Vetenskaper, Helsingborg,Institutionen för kliniska vetenskaper, Lund,Centrum för hjärtstopp,Forskargrupper vid Lunds universitet,SEBRA Sepsis and Bacterial Resistance Alliance,Anesthesiology and Intensive Care,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine,Clinical Sciences, Helsingborg,Department of Clinical Sciences, Lund,Center for cardiac arrest,Lund University Research Groups
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(creator_code:org_t)
- Elsevier, 2022
- 2022
- English.
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In: Resuscitation Plus. - : Elsevier. - 2666-5204. ; 10
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Abstract
Subject headings
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- Background: Several biochemical markers in blood correlate with the magnitude of brain injury and may be used to predict neurological outcome after cardiac arrest. We present a protocol for the evaluation of prognostic accuracy of brain injury markers after cardiac arrest. The aim is to define the best predictive marker and to establish clinically useful cut-off levels for routine implementation. Methods: Prospective international multicenter trial within the Targeted Hypothermia versus Targeted Normothermia after Out-of-Hospital Cardiac Arrest (TTM2) trial in collaboration with Roche Diagnostics International AG. Samples were collected 0, 24, 48, and 72 hours after randomisation (serum) and 0 and 48 hours after randomisation (plasma), and pre-analytically processed at each site before storage in a central biobank. Routine markers neuron-specific enolase (NSE) and S100B, and neurofilament light, total-tau and glial fibrillary acidic protein will be batch analysed using novel Elecsys (R) electrochemiluminescence immunoassays on a Cobas e601 instrument. Results: Statistical analysis will be reported according to the Standards for Reporting Diagnostic accuracy studies (STARD) and will include comparisons for prediction of good versus poor functional outcome at six months post-arrest, by modified Rankin Scale (0-3 vs. 4-6), using logistic regression models and receiver operating characteristics curves, evaluation of mortality at six months according to biomarker levels and establishment of cut-off values for prediction of poor neurological outcome at 95-100% specificities. Conclusions: This prospective trial may establish a standard methodology and clinically appropriate cut-off levels for the optimal biomarker of brain injury which predicts poor neurological outcome after cardiac arrest.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Anestesi och intensivvård (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Anesthesiology and Intensive Care (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
Keyword
- Cardiac arrest
- Brain injury markers
- Neurofilament light
- NFL
- Total-tau
- glial fibrially acidic protein
- GFAP
- S100
- Neuron specific enolase
- NSE
- Prognostication
- outcome
- biomarkers
- Protocol
- Brain injury markers
- Cardiac arrest
- GFAP, S100
- Neurofilament light
- Neuron specific enolase
- NFL
- NSE
- Prognostication, outcome, biomarkers
- Protocol
- Total-tau, glial fibrially acidic protein
- GFAP
- S100
- Prognostication
- outcome
- biomarkers
- Total-tau
- glial fibrially acidic protein
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Moseby-Knappe, M ...
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Levin, Helena
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Blennow, Kaj
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Ullen, Susann
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Zetterberg, Henr ...
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Lilja, Gisela
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show more...
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Dankiewicz, Jose ...
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Jakobsen, Janus ...
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Lagebrant, Alice
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Friberg, Hans
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Nichol, Alistair
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Ainschough, Kate
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Eastwood, Glenn ...
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Wise, Matt P.
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Thomas, Matthew
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Keeble, Thomas
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Cariou, Alain
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Leithner, Christ ...
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Rylander, Christ ...
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Düring, Joachim
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Belohlavek, Jan
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Grejs, Anders
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Borgquist, Ola
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Undén, Johan
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Simon, Maryline
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Rolny, Vinzent
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Piehler, Alex
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Cronberg, Tobias
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Nielsen, Niklas
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Anesthesiology a ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Neurology
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cardiac and Card ...
- Articles in the publication
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Resuscitation Pl ...
- By the university
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Uppsala University
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Lund University
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University of Gothenburg