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Clonal haematopoiesis as a risk factor for therapy-related myeloid neoplasms in patients with chronic lymphocytic leukaemia treated with chemo-(immuno)therapy

Voso, Maria-Teresa (author)
Univ Tor Vergata, Dept Biomed & Prevent, Rome, Italy.
Pandzic, Tatjana (author)
Uppsala universitet,Science for Life Laboratory, SciLifeLab,Medicinsk genetik och genomik,Uppsala Univ Hosp, Dept Clin Genet, Uppsala, Sweden.
Falconi, Giulia (author)
Univ Tor Vergata, Dept Biomed & Prevent, Rome, Italy.
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Dencic-Fekete, Marija (author)
Clin Ctr Serbia, Clin Hematol, Belgrade, Serbia.
De Bellis, Eleonora (author)
Univ Tor Vergata, Dept Biomed & Prevent, Rome, Italy.
Scarfo, Lydia (author)
IRCCS Osped San Raffaele, Div Expt Oncol, Strateg Res Programme CLL, Milan, Italy.;Univ Vita Salute San Raffaele, Milan, Italy.
Ljungström, Viktor, 1986- (author)
Uppsala universitet,Science for Life Laboratory, SciLifeLab,Experimentell och klinisk onkologi,Uppsala Univ Hosp, Dept Clin Genet, Uppsala, Sweden.
Iskas, Michail (author)
G Papanicolaou Hosp, Hematol Dept, Thessaloniki, Greece.;G Papanicolaou Hosp, HCT Unit, Thessaloniki, Greece.
Del Poeta, Giovanni (author)
Univ Tor Vergata, Dept Biomed & Prevent, Rome, Italy.
Ranghetti, Pamela (author)
IRCCS Osped San Raffaele, Div Expt Oncol, Strateg Res Programme CLL, Milan, Italy.;Univ Vita Salute San Raffaele, Milan, Italy.
Laidou, Stamatia (author)
Ctr Res & Technol Hellas, Inst Appl Biosci, Thessaloniki, Greece.
Cristiano, Antonio (author)
Univ Tor Vergata, Dept Biomed & Prevent, Rome, Italy.
Plevova, Karla (author)
Masaryk Univ, Fac Med, Inst Med Genet & Genom, Brno, Czech Republic.;Univ Hosp Brno, Dept Internal Med Haematol & Oncol, Brno, Czech Republic.
Imbergamo, Silvia (author)
Hosp Padua, Dept Hematol, Hematol & Clin Immunol, Padua, Italy.
Engvall, Marie (author)
Uppsala universitet,Medicinsk genetik och genomik,Science for Life Laboratory, SciLifeLab,Uppsala Univ Hosp, Dept Clin Genet, Uppsala, Sweden.
Zucchetto, Antonella (author)
IRCCS, Clin & Expt Onco Hematol Unit, Ctr Riferimento Oncol Aviano CRO, Aviano, Italy.
Salvetti, Chiara (author)
Univ Turin, Div Hematol, Turin, Italy.
Mauro, Francesca R. (author)
Sapienza Univ, Dept Translat & Precis Med, Hematol, Rome, Italy.
Stavroyianni, Niki (author)
G Papanicolaou Hosp, Hematol Dept, Thessaloniki, Greece.;G Papanicolaou Hosp, HCT Unit, Thessaloniki, Greece.
Cavelier, Lucia (author)
Uppsala universitet,Science for Life Laboratory, SciLifeLab,Medicinsk genetik och genomik,Uppsala Univ Hosp, Dept Clin Genet, Uppsala, Sweden.
Ghia, Paolo (author)
IRCCS Osped San Raffaele, Div Expt Oncol, Strateg Res Programme CLL, Milan, Italy.;Univ Vita Salute San Raffaele, Milan, Italy.
Stamatopoulos, Kostas (author)
Karolinska Institutet
Fabiani, Emiliano (author)
Univ Tor Vergata, Dept Biomed & Prevent, Rome, Italy.;UniCamillus St Camillus Int Univ Hlth Sci, Rome, Italy.
Baliakas, Panagiotis, 1977- (author)
Uppsala universitet,Science for Life Laboratory, SciLifeLab,Experimentell och klinisk onkologi,Uppsala Univ Hosp, Dept Clin Genet, Uppsala, Sweden.
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Univ Tor Vergata, Dept Biomed & Prevent, Rome, Italy Science for Life Laboratory, SciLifeLab (creator_code:org_t)
2022-03-11
2022
English.
In: British Journal of Haematology. - : John Wiley & Sons. - 0007-1048 .- 1365-2141. ; 198:1, s. 103-113
Related links:
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  • Journal article (peer-reviewed)
Abstract Subject headings
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  • Clonal haematopoiesis of indeterminate potential (CHIP) may predispose for the development of therapy-related myeloid neoplasms (t-MN). Using target next-generation sequencing (t-NGS) panels and digital droplet polymerase chain reactions (ddPCR), we studied the myeloid gene mutation profiles of patients with chronic lymphocytic leukaemia (CLL) who developed a t-MN after treatment with chemo-(immuno)therapy. Using NGS, we detected a total of 30 pathogenic/likely pathogenic (P/LP) variants in 10 of 13 patients with a t-MN (77%, median number of variants for patient: 2, range 0-6). The prevalence of CHIP was then backtracked in paired samples taken at CLL diagnosis in eight of these patients. Six of them carried at least one CHIP-variant at the time of t-MN (median: 2, range: 1-5), and the same variants were present in the CLL sample in five cases. CHIP variants were present in 34 of 285 patients from a population-based CLL cohort, which translates into a significantly higher prevalence of CHIP in patients with a CLL who developed a t-MN, compared to the population-based cohort (5/8, 62.5% vs. 34/285, 12%, p = 0.0001). Our data show that CHIP may be considered as a novel parameter affecting treatment algorithms in patients with CLL, and highlight the potential of using chemo-free therapies in CHIP-positive cases.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Hematologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Hematology (hsv//eng)

Keyword

CHIP and FCR
CLL
t-MN

Publication and Content Type

ref (subject category)
art (subject category)

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