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mafba and mafbb dif...
mafba and mafbb differentially regulate lymphatic endothelial cell migration in topographically distinct manners
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- Arnold, Hannah (author)
- Uppsala universitet,Vaskulärbiologi
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- Panara, Virginia (author)
- Uppsala universitet,Paleobiologi,Vaskulärbiologi
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- Hussmann, Melina (author)
- WWU Munster, Med Fac, Inst Cardiovasc Organogenesis & Regenerat, Munster, Germany.
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- Gorniok, Beata Filipek (author)
- Uppsala universitet,Institutionen för medicinsk biokemi och mikrobiologi
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- Skoczylas, Renae (author)
- Uppsala universitet,Vaskulärbiologi
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- Ranefall, Petter, 1968- (author)
- Uppsala universitet,Avdelningen för visuell information och interaktion
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- Gloger, Marleen (author)
- Uppsala universitet,Vaskulärbiologi
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- Allalou, Amin, 1981- (author)
- Uppsala universitet,Science for Life Laboratory, SciLifeLab,Bildanalys och människa-datorinteraktion,Avdelningen för visuell information och interaktion
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- Hogan, Benjamin M. (author)
- Univ Melbourne, Dept Anat & Physiol, Melbourne, Vic 3000, Australia.;Univ Melbourne, Sir Peter MacCallum Dept Oncol, Melbourne, Vic 3000, Australia.;Peter MacCallum Canc Ctr, Organogenesis & Canc Program, Melbourne, Vic 3000, Australia.
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- Schulte-Merker, Stefan (author)
- WWU Munster, Med Fac, Inst Cardiovasc Organogenesis & Regenerat, Munster, Germany.
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- Koltowska, Katarzyna (author)
- Uppsala universitet,Institutionen för immunologi, genetik och patologi
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(creator_code:org_t)
- Elsevier, 2022
- 2022
- English.
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In: Cell Reports. - : Elsevier. - 2211-1247. ; 39:12
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https://uu.diva-port... (primary) (Raw object)
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Abstract
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- Lymphangiogenesis, formation of lymphatic vessels from pre-existing vessels, is a dynamic process that requires cell migration. Regardless of location, migrating lymphatic endothelial cell (LEC) progenitors probe their surroundings to form the lymphatic network. Lymphatic-development regulation requires the transcription factor MAFB in different species. Zebrafish Mafba, expressed in LEC progenitors, is essential for their migration in the trunk. However, the transcriptional mechanism that orchestrates LEC migration in different lymphatic endothelial beds remains elusive. Here, we uncover topographically different requirements of the two paralogs, Mafba and Mafbb, for LEC migration. Both mafba and mafbb are necessary for facial lymphatic development, but mafbb is dispensable for trunk lymphatic development. On the molecular level, we demonstrate a regulatory network where Vegfc-Vegfd-SoxF-Mafba-Mafbb is essential in facial lymphangiogenesis. We identify that mafba and mafbb tune the directionality of LEC migration and vessel morphogenesis that is ultimately necessary for lymphatic function.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Arnold, Hannah
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Panara, Virginia
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Hussmann, Melina
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Gorniok, Beata F ...
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Skoczylas, Renae
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Ranefall, Petter ...
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show more...
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Gloger, Marleen
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Allalou, Amin, 1 ...
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Hogan, Benjamin ...
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Schulte-Merker, ...
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Koltowska, Katar ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Cell and Molecul ...
- Articles in the publication
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Cell Reports
- By the university
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Uppsala University