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Frequent productive...
Frequent productive cough : Symptom burden and future exacerbation risk among patients with asthma and/or COPD in the NOVELTY study
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- Hughes, Rod (författare)
- AstraZeneca, Res & Early Dev, Resp & Immunol, Clin, Cambridge, England.
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- Rapsomaniki, Eleni (författare)
- AstraZeneca, Real World Data Sci, BioPharmaceut Med, Cambridge, England.
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- Janson, Christer (författare)
- Uppsala universitet,Lung- allergi- och sömnforskning
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- Keen, Christina (författare)
- AstraZeneca, Res & Early Dev, Resp & Immunol, Clin,BioPharmaceut R&D, Gothenburg, Sweden.
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- Make, Barry J. (författare)
- Natl Jewish Hlth, Denver, CO USA.;Univ Colorado Denver, Denver, CO USA.
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- Burgel, Pierre-Regis (författare)
- Cochin Hosp, Assistance Publ Hop Paris, Dept Resp Med, Paris, France.;Univ Paris, Inst Cochin, Inserm U1016, Paris, France.
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- Tomaszewski, Erin L. (författare)
- AstraZeneca, Patient Centered Sci, BioPharmaceut Med, Gaithersburg, MD USA.
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- Mullerova, Hana (författare)
- AstraZeneca, Resp & Immunol, Med & Payer Evidence, BioPharmaceut Med, Cambridge, England.
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- Reddel, Helen K. (författare)
- Woolcock Inst Med Res, Sydney, NSW, Australia.;Univ Sydney, Sydney, NSW, Australia.
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AstraZeneca, Res & Early Dev, Resp & Immunol, Clin, Cambridge, England AstraZeneca, Real World Data Sci, BioPharmaceut Med, Cambridge, England. (creator_code:org_t)
- Elsevier, 2022
- 2022
- Engelska.
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Ingår i: Respiratory Medicine. - : Elsevier. - 0954-6111 .- 1532-3064. ; 200
- Relaterad länk:
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https://doi.org/10.1...
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https://uu.diva-port... (primary) (Raw object)
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Introduction: Persistent cough with sputum production is an important clinical trait in chronic obstructive pulmonary disease (COPD). We defined "frequent productive cough" based on 2 questions from the St George's Respiratory Questionnaire (SGRQ) and sought to determine its occurrence and associated outcomes in patients with physician-assigned asthma and/or COPD from the NOVELTY study. Methods: Frequent productive cough was defined as cough and sputum production most or several days/week for the past 3 months (scoring >= 3 for both SGRQ questions). Relationships with baseline disease characteristics and exacerbations over 12 months' follow-up were examined using logistic regression. Results: Baseline SGRQ data were available for 7125 patients, of whom 31.3% had frequent productive cough. It was more common in asthma + COPD (38.8%) and COPD (38.1%) than asthma (25.0%), increasing with physician-assessed severity, and in current versus former and never smokers. Patient-reported symptomatic worsening was more common in patients with versus without frequent productive cough. Reduced post-bronchodilator FEV1 (odds ratio [OR] per 10% decrement 1.14 [95% confidence interval 1.11-1.16]) and history of pollutant exposure at home/work (OR 1.50 [1.33-1.69]) were associated with frequent productive cough in all diagnoses. Patients with baseline frequent productive cough were more likely to have >= 1 exacerbation over the subsequent 12 months (OR 1.71 [1.52-1.93]), including exacerbations requiring hospital admission and those treated with oral corticosteroids. Conclusions: Frequent productive cough represents an important indicator of adverse clinical outcomes across asthma and/or COPD. Research into the underlying pathologic mechanisms is required to support targeted therapy development.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Lungmedicin och allergi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Respiratory Medicine and Allergy (hsv//eng)
Nyckelord
- Frequent productive cough
- Chronic bronchitis
- Chronic mucus hypersecretion
- Obstructive lung diseases
- Patient-reported outcome measures
- Sputum
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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