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Selected recent adv...
Selected recent advances in understanding the role of human mast cells in health and disease
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- Levi-Schaffer, Francesca (author)
- Hebrew Univ Jerusalem, Pharmacol & Expt Therapeut Unit, Inst Drug Res, Sch Pharm,Fac Med, POB 12272, IL-91120 Jerusalem, Israel
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- Gibbs, Bernhard F. (author)
- Carl von Ossietzky Univ Oldenburg, Dept Human Med, Oldenburg, Germany
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- Hallgren, Jenny (author)
- Uppsala universitet,Institutionen för medicinsk biokemi och mikrobiologi
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- Pucillo, Carlo (author)
- Univ Udine, Lab Immunol, Dept Med, Udine, Italy
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- Redegeld, Frank (author)
- Univ Utrecht, Fac Sci, Div Pharmacol, Utrecht Inst Pharmaceut Sci, Utrecht, Netherlands
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- Siebenhaar, Frank (author)
- Charite Univ Med Berlin, Inst Allergol, Charitepl 1, D-10117 Berlin, Germany.;Free Univ Berlin, Berlin, Germany.;Humboldt Univ, Berlin, Germany.;Fraunhofer Inst Translat Med & Pharmacol, ITMP Allergol & Immunol, Berlin, Germany
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- Vitte, Joana (author)
- Aix Marseille Univ, AP HM, IRD, MEPHI, Marseille, France.;IDESP, INSERM UA 11, Montpellier, France
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- Mezouar, Soraya (author)
- Aix Marseille Univ, IRD, MEPHI, Marseille, France
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- Michel, Moiese (author)
- Aix Marseille Univ, AP HM, IRD, MEPHI, Marseille, France.;CHU Nimes, Immunol Lab, Nimes, France
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- Puzzovio, Pier Giorgio (author)
- Hebrew Univ Jerusalem, Pharmacol & Expt Therapeut Unit, Inst Drug Res, Sch Pharm,Fac Med, POB 12272, IL-91120 Jerusalem, Israel
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- Maurer, Marcus (author)
- Charite Univ Med Berlin, Inst Allergol, Charitepl 1, D-10117 Berlin, Germany.;Free Univ Berlin, Berlin, Germany.;Humboldt Univ, Berlin, Germany.;Fraunhofer Inst Translat Med & Pharmacol, ITMP Allergol & Immunol, Berlin, Germany
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(creator_code:org_t)
- Elsevier, 2022
- 2022
- English.
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In: Journal of Allergy and Clinical Immunology. - : Elsevier. - 0091-6749 .- 1097-6825. ; 149:6, s. 1833-1844
- Related links:
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https://www.scienced...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
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- Mast cells are highly granular tissue-resident cells and key drivers of inflammation, particularly in allergies as well as in other inflammatory diseases. Most mast cell research was initially conducted in rodents but has increasingly shifted to the human system, with the advancement of research technologies and methodologies. Today we can analyze primary human cells including rare subpopulations, we can produce and maintain mast cells isolated from human tissues, and there are several human mast cell lines. These tools have substantially facilitated our understanding of their role and function in different organs in both health and disease. We can now define more clearly where human mast cells originate from, how they develop, which mediators they store, produce de novo, and release, how they are activated and by which receptors, and which neighboring cells they interact with and by which mechanisms. Considerable progress has also been made regarding the potential contribution of mast cells to disease, which, in turn, has led to the development of novel approaches for preventing key pathogenic effects of mast cells, heralding the era of mast cell-targeted therapeutics. In this review, we present and discuss a selection of some of the most significant advancements and remaining gaps in our understanding of human mast cells during the last 25 years, with a focus on clinical relevance.
Subject headings
- NATURVETENSKAP -- Biologi -- Immunologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Immunology (hsv//eng)
Keyword
- Allergy
- cancer
- human mast cells
- receptors
- signal transduction
Publication and Content Type
- ref (subject category)
- for (subject category)
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- By the author/editor
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Levi-Schaffer, F ...
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Gibbs, Bernhard ...
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Hallgren, Jenny
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Pucillo, Carlo
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Redegeld, Frank
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Siebenhaar, Fran ...
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show more...
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Vitte, Joana
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Mezouar, Soraya
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Michel, Moiese
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Puzzovio, Pier G ...
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Maurer, Marcus
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- About the subject
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- NATURAL SCIENCES
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NATURAL SCIENCES
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and Biological Scien ...
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and Immunology
- Articles in the publication
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Journal of Aller ...
- By the university
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Uppsala University