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Quantitative proteomics approach reveals novel biomarkers and pathological mechanism of keloid
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- Liu, Jian (author)
- Department of Plastic Surgery, Shandong Provincial Qianfoshan Hospital Cheeloo College of Medicine, Shandong University Jinan Shandong China;Department of Plastic Surgery The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital Jinan Shandong China;Jinan Clinical Research Center for Tissue Engineering Skin Regeneration and wound Repair Jinan Shandong China
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- Yang, Chunhua (author)
- Shandong Technology Innovation Center of Molecular Targeting and Intelligent Diagnosis and Treatment, School of Pharmacy Binzhou Medical University Yantai Shandong China
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- Zhang, Huayu (author)
- Department of Plastic Surgery, Shandong Provincial Qianfoshan Hospital Cheeloo College of Medicine, Shandong University Jinan Shandong China;Jinan Clinical Research Center for Tissue Engineering Skin Regeneration and wound Repair Jinan Shandong China
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- (creator_code:org_t)
- 2022-04-26
- 2022
- English.
- In: PROTEOMICS - Clinical Applications. - : John Wiley & Sons. - 1862-8346 .- 1862-8354. ; 16:4
- Journal article (peer-reviewed)
Abstract
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- Background Keloid is a pathological skin scar formation with complex and unclear molecular pathology mechanism. Novel biomarkers and associated mechanisms are needed to improve current therapies.Objectives To identify novel biomarkers and underlying pathological mechanisms of keloids.MethodsSix pairs of keloid scar tissues and corresponding normal skin tissues were quantitatively analyzed by a high-resolution label-free mass spectrometry-based proteomics approach. Differential protein expression data was further analyzed by a comprehensive bioinformatics approach to identify novel biomarkers and mechanistic pathways for keloid formation. Candidate biomarkers were validated experimentally.Results In total, 1359 proteins were identified by proteomic analysis. Of these, 206 proteins exhibited a significant difference in expression between keloid scar and normal skin tissues. RCN3 and CALU were significantly upregulated in keloids. RCN1 and PDGFRL were uniquely expressed in keloids. Pathway analysis suggested that the XBP1-mediated unfolded protein response (UPR) pathway was involved in keloid formation. Moreover, a PDGFRL centric gene coexpression network was constructed to illustrate its function in skin.Conclusions and Clinical Relevance Our study proposed four novel biomarkers and highlighted the role of XBP1-mediated UPR pathway in the pathology of keloids. It provided novel biological insights that contribute to develop novel therapeutic strategies for keloids.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)
Keyword
- bioinformatics
- keloid
- PDGFRL
- proteomics
- XBP1
Publication and Content Type
- ref (subject category)
- art (subject category)
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- Liu, Jian
- Yang, Chunhua
- Zhang, Huayu
- Hu, Wei
- Bergquist, Jonas
- Wang, Helen
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- Deng, Tingzhi
- Yang, Xueling
- Zhang, Chao
- Zhu, Yanping
- Chi, Xiaodong
- Mi, Jia
- Wang, Yibing
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- Uppsala University
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