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First Experimental ...
First Experimental Evidence for Reversibility of Ammonia Loss from Asparagine
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- Wang, Jijing (author)
- Karolinska Inst, Dept Med Biochem & Biophys, SE-17165 Stockholm, Sweden.
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- Rodin, Sergey (author)
- Uppsala universitet,Institutionen för kirurgiska vetenskaper,Karolinska Inst, Dept Med Biochem & Biophys, SE-17165 Stockholm, Sweden.
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- Saei, Amir Ata (author)
- Karolinska Institutet
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- Zhang, Xuepei (author)
- Karolinska Inst, Dept Med Biochem & Biophys, SE-17165 Stockholm, Sweden.
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- Zubarev, Roman A. (author)
- Karolinska Institutet
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Karolinska Inst, Dept Med Biochem & Biophys, SE-17165 Stockholm, Sweden Institutionen för kirurgiska vetenskaper (creator_code:org_t)
- 2022-07-28
- 2022
- English.
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In: International Journal of Molecular Sciences. - : MDPI AG. - 1661-6596 .- 1422-0067. ; 23:15
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Abstract
Subject headings
Close
- Ammonia loss from (L)-asparaginyls is a nonenzymatic reaction spontaneously occurring in all proteins and eventually resulting in damaging isoaspartate residues that hamper protein function and induce proteinopathy related to aging. Here, we discuss theoretical considerations supporting the possibility of a full repair reaction and present the first experimental evidence of its existence. If confirmed, the true repair of (L)-asparaginyl deamidation could open new avenues for preventing aging and neurodegenerative diseases.
Subject headings
- NATURVETENSKAP -- Biologi -- Biokemi och molekylärbiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Biochemistry and Molecular Biology (hsv//eng)
Keyword
- deamidation
- isoaspartate
- anti-aging
- reverse reaction
- mass spectrometry
Publication and Content Type
- ref (subject category)
- art (subject category)
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