First Experimental Evidence for Reversibility of Ammonia Loss from Asparagine

Wang, Jijing (author): Karolinska Inst, Dept Med Biochem & Biophys, SE-17165 Stockholm, Sweden.

Rodin, Sergey (author): Uppsala universitet,Institutionen för kirurgiska vetenskaper,Karolinska Inst, Dept Med Biochem & Biophys, SE-17165 Stockholm, Sweden.

Zhang, Xuepei (author): Karolinska Inst, Dept Med Biochem & Biophys, SE-17165 Stockholm, Sweden.

Karolinska Inst, Dept Med Biochem & Biophys, SE-17165 Stockholm, Sweden Institutionen för kirurgiska vetenskaper (creator_code:org_t)

2022-07-28
2022
English.
In: International Journal of Molecular Sciences. - : MDPI AG. - 1661-6596 .- 1422-0067. ; 23:15

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Abstract Subject headings

Ammonia loss from (L)-asparaginyls is a nonenzymatic reaction spontaneously occurring in all proteins and eventually resulting in damaging isoaspartate residues that hamper protein function and induce proteinopathy related to aging. Here, we discuss theoretical considerations supporting the possibility of a full repair reaction and present the first experimental evidence of its existence. If confirmed, the true repair of (L)-asparaginyl deamidation could open new avenues for preventing aging and neurodegenerative diseases.

By the author/editor: Wang, Jijing; Rodin, Sergey; Saei, Amir Ata; Zhang, Xuepei; Zubarev, Roman A ...

About the subject

NATURAL SCIENCES: NATURAL SCIENCES; and Biological Scien ...; and Biochemistry and ...

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