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- Wang, JijingKarolinska Inst, Dept Med Biochem & Biophys, SE-17165 Stockholm, Sweden. (author)
First Experimental Evidence for Reversibility of Ammonia Loss from Asparagine
- Article/chapterEnglish2022
Publisher, publication year, extent ...
- 2022-07-28
- MDPI AG,2022
- electronicrdacarrier
Numbers
- LIBRIS-ID:oai:DiVA.org:uu-482734
- https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-482734URI
- https://doi.org/10.3390/ijms23158371DOI
- http://kipublications.ki.se/Default.aspx?queryparsed=id:150466922URI
Supplementary language notes
- Language:English
- Summary in:English
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Notes
- Ammonia loss from (L)-asparaginyls is a nonenzymatic reaction spontaneously occurring in all proteins and eventually resulting in damaging isoaspartate residues that hamper protein function and induce proteinopathy related to aging. Here, we discuss theoretical considerations supporting the possibility of a full repair reaction and present the first experimental evidence of its existence. If confirmed, the true repair of (L)-asparaginyl deamidation could open new avenues for preventing aging and neurodegenerative diseases.
Subject headings and genre
- NATURVETENSKAP Biologi Biokemi och molekylärbiologi hsv//swe
- NATURAL SCIENCES Biological Sciences Biochemistry and Molecular Biology hsv//eng
- deamidation
- isoaspartate
- anti-aging
- reverse reaction
- mass spectrometry
Added entries (persons, corporate bodies, meetings, titles ...)
- Rodin, SergeyUppsala universitet,Institutionen för kirurgiska vetenskaper,Karolinska Inst, Dept Med Biochem & Biophys, SE-17165 Stockholm, Sweden.(Swepub:uu)serro142 (author)
- Saei, Amir AtaKarolinska Institutet (author)
- Zhang, XuepeiKarolinska Inst, Dept Med Biochem & Biophys, SE-17165 Stockholm, Sweden. (author)
- Zubarev, Roman A.Karolinska Institutet (author)
- Karolinska Inst, Dept Med Biochem & Biophys, SE-17165 Stockholm, Sweden.Institutionen för kirurgiska vetenskaper (creator_code:org_t)
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- In:International Journal of Molecular Sciences: MDPI AG23:151661-65961422-0067
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