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ESR2 expression in ...
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Ahmed, FoziaUppsala universitet,Klinisk diabetologi och metabolism
(author)
ESR2 expression in subcutaneous adipose tissue is related to body fat distribution in women, and knockdown impairs preadipocyte differentiation
- Article/chapterEnglish2022
Publisher, publication year, extent ...
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2022-08-17
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Informa UK Limited,2022
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electronicrdacarrier
Numbers
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LIBRIS-ID:oai:DiVA.org:uu-483752
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-483752URI
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https://doi.org/10.1080/21623945.2022.2102116DOI
Supplementary language notes
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Language:English
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Summary in:English
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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Oestrogen receptor 2 (ESR2) expression has been shown to be higher in subcutaneous adipose tissue (SAT) from postmenopausal compared to premenopausal women. The functional significance of altered ESR2 expression is not fully known. This study investigates the role of ESR2 for adipose tissue lipid and glucose metabolism. SAT biopsies were obtained from 44 female subjects with or without T2D. Gene expression of ESR2 and markers of adipose function and metabolism was assessed. ESR2 knockdown was performed using CRISPR/Cas9 in preadipocytes isolated from SAT of females, and differentiation rate, lipid storage, and glucose uptake were measured. ESR2 expression was inversely correlated with measures of central obesity and expression of some fatty acid oxidation markers, and positively correlated with lipid storage and glucose transport markers. Differentiation was reduced in ESR2 knockdown preadipocytes. This corresponded to reduced expression of markers of differentiation and lipogenesis. Glucose uptake was reduced in knockdown adipocytes. Our results indicate that ESR2 deficiency in women is associated with visceral adiposity and impaired subcutaneous adipocyte differentiation as well as glucose and lipid utilization. High ESR2 expression, as seen after menopause, could be a contributing factor to SAT expansion. This may support a possible target to promote a healthy obesity phenotype.
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Added entries (persons, corporate bodies, meetings, titles ...)
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Hetty, Susanne,PhD,1979-Uppsala universitet,Klinisk diabetologi och metabolism(Swepub:uu)sustr921
(author)
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Vranic, MilicaUppsala universitet,Klinisk diabetologi och metabolism(Swepub:uu)milvr380
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Fanni, GiovanniUppsala universitet,Klinisk diabetologi och metabolism(Swepub:uu)giofa361
(author)
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Kullberg, Joel,1979-Uppsala universitet,Radiologi(Swepub:uu)jokul377
(author)
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Pereira, Maria J.,1981-Uppsala universitet,Klinisk diabetologi och metabolism(Swepub:uu)marpe927
(author)
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Eriksson, JanUppsala universitet,Klinisk diabetologi och metabolism(Swepub:uu)janer909
(author)
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Uppsala universitetKlinisk diabetologi och metabolism
(creator_code:org_t)
Related titles
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In:Adipocyte: Informa UK Limited11:1, s. 434-4472162-39452162-397X
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