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Repeated Measures o...
Repeated Measures of Modified Rankin Scale Scores to Assess Functional Recovery From Stroke : AFFINITY Study Findings
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Chye, Alexander (author)
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Hackett, Maree L (author)
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Hankey, Graeme J (author)
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- Lundström, Erik, 1964- (author)
- Uppsala universitet,Neurologi
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Almeida, Osvaldo P (author)
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Gommans, John (author)
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Dennis, Martin (author)
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Jan, Stephen (author)
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Mead, Gillian E (author)
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Ford, Andrew H (author)
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Beer, Christopher Etherton (author)
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Flicker, Leon (author)
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Delcourt, Candice (author)
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Billot, Laurent (author)
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Anderson, Craig S (author)
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Stibrant Sunnerhagen, Katharina (author)
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Yi, Qilong (author)
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Bompoint, Severine (author)
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Nguyen, Thang Huy (author)
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Lung, Thomas (author)
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(creator_code:org_t)
- Ovid Technologies (Wolters Kluwer Health), 2022
- 2022
- English.
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In: Journal of the American Heart Association. - : Ovid Technologies (Wolters Kluwer Health). - 2047-9980. ; 11:16
- Related links:
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https://doi.org/10.1...
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https://uu.diva-port... (primary) (Raw object)
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
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- Background: Function after acute stroke using the modified Rankin Scale (mRS) is usually assessed at a point in time. The analytical implications of serial mRS measurements to evaluate functional recovery over time is not completely understood. We compare repeated-measures and single-measure analyses of the mRS from a randomized clinical trialMethods and Results: Serial mRS data from AFFINITY (Assessment of Fluoxetine in Stroke Recovery), a double-blind placebo randomized clinical trial of fluoxetine following stroke (n=1280) were analyzed to identify demographic and clinical associations with functional recovery (reduction in mRS) over 12 months. Associations were identified using single-measure (day 365) and repeated-measures (days 28, 90, 180, and 365) partial proportional odds logistic regression. Ninety-five percent of participants experienced a reduction in mRS after 12 months. Functional recovery was associated with age at stroke <70 years; no prestroke history of diabetes, coronary heart disease, or ischemic stroke; prestroke history of depression, a relationship partner, living with others, independence, or paid employment; no fluoxetine intervention; ischemic stroke (compared with hemorrhagic); stroke treatment in Vietnam (compared with Australia or New Zealand); longer time since current stroke; and lower baseline National Institutes of Health Stroke Scale & Patient Health Questionnaire-9 scores. Direction of associations was largely concordant between single-measure and repeated-measures models. Association strength and variance was generally smaller in the repeated-measures model compared with the single-measure model.Conclusions: Repeated-measures may improve trial precision in identifying trial associations and effects. Further repeated-measures stroke analyses are required to prove methodological value. Registration URL: http://www.anzctr.org.au; Unique identifier: ACTRN12611000774921.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
Keyword
- cerebrovascular disease
- functional outcomes
- modified Rankin Scale
- partial proportional odds
- repeated measures
- stroke
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Chye, Alexander
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Hackett, Maree L
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Hankey, Graeme J
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Lundström, Erik, ...
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Almeida, Osvaldo ...
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Gommans, John
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show more...
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Dennis, Martin
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Jan, Stephen
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Mead, Gillian E
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Ford, Andrew H
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Beer, Christophe ...
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Flicker, Leon
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Delcourt, Candic ...
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Billot, Laurent
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Anderson, Craig ...
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Stibrant Sunnerh ...
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Yi, Qilong
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Bompoint, Severi ...
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Nguyen, Thang Hu ...
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Lung, Thomas
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Neurology
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Journal of the A ...
- By the university
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Uppsala University