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The anti-inflammato...
The anti-inflammatory peptide Catestatin blocks chemotaxis
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- Muntjewerff, Elke M. (author)
- Radboud Univ Nijmegen Med Ctr, Radboud Inst Mol Life Sci, Dept Tumor Immunol, Nijmegen, Netherlands
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- Parv, Kristel (author)
- Uppsala universitet,Institutionen för medicinsk cellbiologi,Science for Life Laboratory, SciLifeLab
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- Mahata, Sushil K. (author)
- Univ Calif San Diego, VA San Diego Healthcare Syst, La Jolla, CA USA.;Univ Calif San Diego, Dept Med, La Jolla, CA USA
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- van Riessen, N. Koen (author)
- Radboud Univ Nijmegen Med Ctr, Radboud Inst Mol Life Sci, Dept Tumor Immunol, Nijmegen, Netherlands
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- Phillipson, Mia, 1973- (author)
- Uppsala universitet,Institutionen för medicinsk cellbiologi,Science for Life Laboratory, SciLifeLab
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- Christoffersson, Gustaf (author)
- Uppsala universitet,Institutionen för medicinsk cellbiologi,Science for Life Laboratory, SciLifeLab
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- van den Bogaart, Geert (author)
- Radboud Univ Nijmegen Med Ctr, Radboud Inst Mol Life Sci, Dept Tumor Immunol, Nijmegen, Netherlands.;Univ Groningen, Groningen Biomol Sci & Biotechnol Inst, Dept Mol Immunol & Microbiol, Groningen, Netherlands
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(creator_code:org_t)
- John Wiley & Sons, 2022
- 2022
- English.
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In: Journal of Leukocyte Biology. - : John Wiley & Sons. - 0741-5400 .- 1938-3673. ; 112:2, s. 273-278
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https://uu.diva-port... (primary) (Raw object)
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Abstract
Subject headings
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- Increased levels of the anti-inflammatory peptide Catestatin (CST), a cleavage product of the pro-hormone chromogranin A, correlate with less severe outcomes in hypertension, colitis, and diabetes. However, it is unknown how CST reduces the infiltration of monocytes and macrophages (M phi s) in inflamed tissues. Here, it is reported that CST blocks leukocyte migration toward inflammatory chemokines. By in vitro and in vivo migration assays, it is shown that although CST itself is chemotactic, it blocks migration of monocytes and neutrophils to inflammatory attracting factor CC-chemokine ligand 2 (CCL2) and C-X-C motif chemokine ligand 2 (CXCL2). Moreover, it directs CX(3)CR1(+) M phi s away from pancreatic islets. These findings suggest that the anti-inflammatory actions of CST are partly caused by its regulation of chemotaxis.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)
Keyword
- catestatin
- chemotaxis
- M phi s
- migration
- monocytes
- neutrophil
- pro-angiogenesis
Publication and Content Type
- ref (subject category)
- art (subject category)
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