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Circulating vitamin...
Circulating vitamin C and digestive system cancers : Mendelian randomization study
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- Larsson, Susanna C. (author)
- Karolinska Institutet,Uppsala universitet,Medicinsk epidemiologi
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- Mason, Amy M. (author)
- Karolinska Inst, Inst Environm Med, Unit Cardiovasc & Nutr Epidemiol, Stockholm, Sweden.;Univ Cambridge, British Heart Fdn Cardiovasc Epidemiol Unit, Dept Publ Hlth & Primary Care, Cambridge, Cambs, England.;Univ Cambridge, Natl Inst Hlth Res Cambridge Biomed Res Ctr, Cambridge, Cambs, England.;Cambridge Univ Hosp, Cambridge, Cambs, England.
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- Vithayathil, Mathew (author)
- Univ Cambridge, MRC Canc Unit, Cambridge, Cambs, England.
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- Carter, Paul (author)
- Univ Cambridge, Dept Med, Cambridge, Cambs, England.
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- Kar, Siddhartha (author)
- Univ Bristol, Bristol Med Sch, MRC Integrat Epidemiol Unit, Bristol, Glos, England.
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- Zheng, Ju-Sheng (author)
- Westlake Univ, Sch Life Sci, Key Lab Growth Regulat & Translat Res Zhejiang Pro, Hangzhou, Peoples R China.;Westlake Inst Adv Study, Inst Basic Med Sci, Hangzhou, Peoples R China.
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- Burgess, Stephen (author)
- Univ Cambridge, Dept Publ Hlth & Primary Care, Cambridge, Cambs, England.;Univ Cambridge, MRC Biostat Unit, Cambridge, Cambs, England.
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(creator_code:org_t)
- Elsevier, 2022
- 2022
- English.
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In: Clinical Nutrition. - : Elsevier. - 0261-5614 .- 1532-1983. ; 41:9, s. 2031-2035
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Abstract
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- Background & aims: Vitamin C is an antioxidant with a potential role in the prevention of digestive system cancers, but there is yet no consensus whether vitamin C has a causal role in these cancers. The aim of this study was to utilize Mendelian randomization to decipher the potential causal associations of vitamin C with risk of digestive system cancers.Methods: Ten genetic variants previously found to be significantly associated with circulating vitamin C were used as instrumental variables. Effect size estimates for the genetic associations of the vitamin Cassociated genetic variants with six major malignancies of digestive system were obtained from the FinnGen (N = 309 154) and UK Biobank (N = 367 542) studies. Results from the two studies were combined using meta-analysis.Results: Genetically predicted higher circulating vitamin C showed a suggestive association with lower risk of small intestine and colorectal cancer after accounting for multiple testing. The odds ratio per 1 standard deviation increment in circulating vitamin C was 0.55 (95% confidence interval 0.32-0.94; P = 0.029) for small intestine cancer and 0.84 (95% confidence interval 0.73-0.96; P = 0.013) for colorectal cancer. There was a suggestive association between genetically predicted higher circulating vitamin C with lower risk of liver cancer in FinnGen but no association in the meta-analysis (odds ratio 0.69; 95% CI 0.36-1.32; P = 0.265). Genetically predicted circulating vitamin C was not associated with cancers of the esophagus, stomach, or pancreas.Conclusion: This Mendelian randomization study indicates that vitamin C might play a role in the prevention of small intestine and colorectal cancer. (c) 2022 The Author(s). Published by Elsevier Ltd. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Näringslära (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Nutrition and Dietetics (hsv//eng)
Keyword
- Ascorbic acid
- Cancer
- Digestive system
- Mendelian randomization
- Nutrients
- Vitamin C
Publication and Content Type
- ref (subject category)
- art (subject category)
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